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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

4QPL

Crystal structure of RNF146(RING-WWE)/UbcH5a/iso-ADPr complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0008270molecular_functionzinc ion binding
A0016055biological_processWnt signaling pathway
A0061630molecular_functionubiquitin protein ligase activity
A0072572molecular_functionpoly-ADP-D-ribose binding
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0000166molecular_functionnucleotide binding
B0000209biological_processprotein polyubiquitination
B0004842molecular_functionubiquitin-protein transferase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006511biological_processubiquitin-dependent protein catabolic process
B0016567biological_processprotein ubiquitination
B0016740molecular_functiontransferase activity
B0030514biological_processnegative regulation of BMP signaling pathway
B0031398biological_processpositive regulation of protein ubiquitination
B0032991cellular_componentprotein-containing complex
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0061630molecular_functionubiquitin protein ligase activity
B0061631molecular_functionubiquitin conjugating enzyme activity
B0070936biological_processprotein K48-linked ubiquitination
B1904262biological_processnegative regulation of TORC1 signaling
C0008270molecular_functionzinc ion binding
C0016055biological_processWnt signaling pathway
C0061630molecular_functionubiquitin protein ligase activity
C0072572molecular_functionpoly-ADP-D-ribose binding
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0000166molecular_functionnucleotide binding
D0000209biological_processprotein polyubiquitination
D0004842molecular_functionubiquitin-protein transferase activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006511biological_processubiquitin-dependent protein catabolic process
D0016567biological_processprotein ubiquitination
D0016740molecular_functiontransferase activity
D0030514biological_processnegative regulation of BMP signaling pathway
D0031398biological_processpositive regulation of protein ubiquitination
D0032991cellular_componentprotein-containing complex
D0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
D0061630molecular_functionubiquitin protein ligase activity
D0061631molecular_functionubiquitin conjugating enzyme activity
D0070936biological_processprotein K48-linked ubiquitination
D1904262biological_processnegative regulation of TORC1 signaling
Functional Information from PDB Data
site_idAC1
Number of Residues18
DetailsBINDING SITE FOR RESIDUE V3L A 201
ChainResidue
ALYS61
AARG161
AARG163
ALYS175
AGLY179
AHOH302
AHOH305
AHOH306
AHOH318
AHOH330
ATYR107
AGLY109
AARG110
ATRP114
ATYR116
AILE139
ATYR144
AGLN153
site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 202
ChainResidue
ACYS36
ACYS39
ACYS56
ACYS59
site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 203
ChainResidue
ACYS51
AHIS53
ACYS70
ACYS73
site_idAC4
Number of Residues19
DetailsBINDING SITE FOR RESIDUE V3L C 201
ChainResidue
CLYS61
CTYR107
CGLY109
CARG110
CTRP114
CTYR116
CILE139
CTYR144
CGLN153
CARG161
CARG163
CLYS175
CGLY179
CHOH301
CHOH303
CHOH304
CHOH319
CHOH320
CHOH345
site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN C 202
ChainResidue
CCYS36
CCYS39
CCYS56
CCYS59
site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN C 203
ChainResidue
CCYS51
CHIS53
CCYS70
CCYS73
Functional Information from PROSITE/UniProt
site_idPS00183
Number of Residues16
DetailsUBC_1 Ubiquitin-conjugating (UBC) active site signature. YHPNInsn.GsICLdiL
ChainResidueDetails
BTYR74-LEU89
site_idPS00518
Number of Residues10
DetailsZF_RING_1 Zinc finger RING-type signature. CkHvFCylCV
ChainResidueDetails
ACYS51-VAL60
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues152
DetailsDomain: {"description":"WWE","evidences":[{"source":"PROSITE-ProRule","id":"PRU00248","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues76
DetailsZinc finger: {"description":"RING-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00175","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues14
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues10
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"Q9NTX7","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues292
DetailsDomain: {"description":"UBC core","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsActive site: {"description":"Glycyl thioester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10133","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

247947

PDB entries from 2026-01-21

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