1DCT
| DNA (CYTOSINE-5) METHYLASE FROM HAEIII COVALENTLY BOUND TO DNA | Descriptor: | CALCIUM ION, DNA (5'-D(*AP*CP*CP*AP*GP*CP*AP*GP*GP*(C49)P*CP*AP*CP*CP*AP*GP*TP*G)-3'), DNA (5'-D(*TP*CP*AP*CP*TP*GP*GP*TP*GP*GP*(C5M)P*CP*TP*GP*CP*TP*GP*G)-3'), ... | Authors: | Reinisch, K.M, Chen, L, Verdine, G.L, Lipscomb, W.N. | Deposit date: | 1995-05-17 | Release date: | 1995-09-15 | Last modified: | 2019-11-20 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The crystal structure of HaeIII methyltransferase convalently complexed to DNA: an extrahelical cytosine and rearranged base pairing. Cell(Cambridge,Mass.), 82, 1995
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2HR1
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2I9K
| Engineered Extrahelical Base Destabilization Enhances Sequence Discrimination of DNA Methyltransferase M.HhaI | Descriptor: | 5'-D(*T*GP*AP*TP*AP*GP*CP*GP*CP*TP*AP*TP*C)-3', Modification methylase HhaI, S-ADENOSYL-L-HOMOCYSTEINE | Authors: | Youngblood, B, Shieh, F.K, De Los Rios, S, Perona, J.J, Reich, N.O. | Deposit date: | 2006-09-05 | Release date: | 2006-10-10 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Engineered Extrahelical Base Destabilization Enhances Sequence Discrimination of DNA Methyltransferase M.HhaI J.Mol.Biol., 362, 2006
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2HMY
| BINARY COMPLEX OF HHAI METHYLTRANSFERASE WITH ADOMET FORMED IN THE PRESENCE OF A SHORT NONPSECIFIC DNA OLIGONUCLEOTIDE | Descriptor: | PROTEIN (CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI), S-ADENOSYLMETHIONINE | Authors: | O'Gara, M, Zhang, X, Roberts, R.J, Cheng, X. | Deposit date: | 1999-02-08 | Release date: | 1999-03-19 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.61 Å) | Cite: | Structure of a binary complex of HhaI methyltransferase with S-adenosyl-L-methionine formed in the presence of a short non-specific DNA oligonucleotide. J.Mol.Biol., 287, 1999
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1FJX
| STRUCTURE OF TERNARY COMPLEX OF HHAI METHYLTRANSFERASE MUTANT (T250G) IN COMPLEX WITH DNA AND ADOHCY | Descriptor: | DNA (5'-D(*TP*GP*AP*TP*AP*GP*CP*GP*CP*TP*AP*TP*C)-3'), HHAI DNA METHYLTRANSFERASE, S-ADENOSYL-L-HOMOCYSTEINE, ... | Authors: | Vilkaitis, G, Dong, A, Weinhold, E, Cheng, X, Klimasauskas, S. | Deposit date: | 2000-08-08 | Release date: | 2000-12-15 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.26 Å) | Cite: | Functional roles of the conserved threonine 250 in the target recognition domain of HhaI DNA methyltransferase. J.Biol.Chem., 275, 2000
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7V0E
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1G55
| Structure of human DNMT2, an enigmatic DNA methyltransferase homologue | Descriptor: | BETA-MERCAPTOETHANOL, DNA CYTOSINE METHYLTRANSFERASE DNMT2, GLYCEROL, ... | Authors: | Dong, A, Yoder, J.A, Zhang, X, Zhou, L, Bestor, T.H, Cheng, X. | Deposit date: | 2000-10-30 | Release date: | 2001-01-17 | Last modified: | 2018-06-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure of human DNMT2, an enigmatic DNA methyltransferase homolog that displays denaturant-resistant binding to DNA. Nucleic Acids Res., 29, 2001
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2QRV
| Structure of Dnmt3a-Dnmt3L C-terminal domain complex | Descriptor: | DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3A, S-ADENOSYL-L-HOMOCYSTEINE | Authors: | Jia, D, Cheng, X. | Deposit date: | 2007-07-29 | Release date: | 2007-12-04 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.89 Å) | Cite: | Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation. Nature, 449, 2007
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8C56
| CpG specific M.MpeI methyltransferase crystallized in the presence of 2'-deoxy-5-methylzebularine (5mZ) and 5-methylcytosine containing dsDNA | Descriptor: | Cytosine-specific methyltransferase, DNA (5'-D(*CP*CP*AP*CP*AP*TP*GP*(5PY)P*GP*CP*TP*GP*AP*A)-3'), DNA (5'-D(*GP*TP*TP*CP*AP*GP*(5CM)P*GP*CP*AP*TP*GP*TP*G)-3'), ... | Authors: | Wojciechowski, M, Czapinska, H, Krwawicz, J, Rafalski, D, Bochtler, M. | Deposit date: | 2023-01-06 | Release date: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Cytosine analogues as DNA methyltransferase substrates and inhibitors To Be Published
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8C58
| CpG specific M.MpeI methyltransferase crystallized in the presence of 5-hydroxycytosine and 5-methylcytosine containing dsDNA | Descriptor: | CARBONATE ION, Cytosine-specific methyltransferase, DNA (5'-D(*CP*CP*AP*CP*AP*TP*GP*(5OC)P*GP*CP*TP*GP*AP*A)-3'), ... | Authors: | Wojciechowski, M, Czapinska, H, Krwawicz, J, Rafalski, D, Bochtler, M. | Deposit date: | 2023-01-06 | Release date: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Cytosine analogues as DNA methyltransferase substrates and inhibitors To Be Published
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8C59
| CpG specific M.MpeI methyltransferase crystallized in the presence of 5-bromocytosine (converted to 5mC) and 5-methylcytosine containing dsDNA | Descriptor: | CARBONATE ION, CITRIC ACID, Cytosine-specific methyltransferase, ... | Authors: | Wojciechowski, M, Czapinska, H, Krwawicz, J, Rafalski, D, Bochtler, M. | Deposit date: | 2023-01-06 | Release date: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Cytosine analogues as DNA methyltransferase substrates and inhibitors To Be Published
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8C57
| CpG specific M.MpeI methyltransferase crystallized in the presence of 5,6-dihydro-5-azacytosine (converted to 5m-dhaC) and 5-methylcytosine containing dsDNA | Descriptor: | CARBONATE ION, Cytosine-specific methyltransferase, DNA (5'-D(*CP*CP*AP*CP*AP*TP*GP*(5MA)P*GP*CP*TP*GP*AP*A)-3'), ... | Authors: | Wojciechowski, M, Czapinska, H, Krwawicz, J, Rafalski, D, Bochtler, M. | Deposit date: | 2023-01-06 | Release date: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Cytosine analogues as DNA methyltransferase substrates and inhibitors To Be Published
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2C7Q
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2C7O
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2UYH
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2C7P
| HhaI DNA methyltransferase complex with oligonucleotide containing 2- aminopurine opposite to the target base (GCGC:GMPC) and SAH | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5'-D(*G*GP*AP*TP*GP*(5CM*2PR)*CP*TP*GP*AP*C)-3', 5'-D(*G*TP*CP*AP*GP*CP*GP*CP*AP*TP*CP*C)-3', ... | Authors: | Neely, R.K, Daujotyte, D, Grazulis, S, Magennis, S.W, Dryden, D.T.F, Klimasauskas, S, Jones, A.C. | Deposit date: | 2005-11-25 | Release date: | 2005-12-14 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Time-Resolved Fluorescence of 2-Aminopurine as a Probe of Base Flipping in M.HhaI-DNA Complexes. Nucleic Acids Res., 33, 2005
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2C7R
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2UYC
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2UZ4
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4H0N
| Crystal structure of Spodoptera frugiperda DNMT2 E260A/E261A/K263A mutant | Descriptor: | CALCIUM ION, DNMT2, S-ADENOSYL-L-HOMOCYSTEINE | Authors: | Li, S, Du, J, Yang, H, Yin, J, Zhong, J, Ding, J. | Deposit date: | 2012-09-09 | Release date: | 2012-11-14 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.712 Å) | Cite: | Functional and structural characterization of DNMT2 from Spodoptera frugiperda. J Mol Cell Biol, 5, 2013
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3QV2
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8T1U
| Crystal structure of the DRM2-CTA DNA complex | Descriptor: | DNA (5'-D(P*AP*TP*TP*AP*TP*TP*AP*AP*TP*(C49)P*TP*AP*AP*AP*TP*TP*TP*A)-3'), DNA (5'-D(P*TP*AP*AP*AP*TP*TP*TP*AP*GP*AP*TP*TP*AP*AP*TP*AP*AP*T)-3'), DNA (cytosine-5)-methyltransferase DRM2, ... | Authors: | Chen, J, Lu, J, Song, J. | Deposit date: | 2023-06-03 | Release date: | 2023-11-22 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.91 Å) | Cite: | DNA conformational dynamics in the context-dependent non-CG CHH methylation by plant methyltransferase DRM2. J.Biol.Chem., 299, 2023
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8TDR
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8TE3
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8TE1
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