4ZDJ
 
 | | Crystal structure of the M. tuberculosis CTP synthase PyrG in complex with two UTP molecules | | Descriptor: | CTP synthase, GLYCEROL, MAGNESIUM ION, ... | | Authors: | Bellinzoni, M, Barilone, N, Alzari, P.M. | | Deposit date: | 2015-04-17 | | Release date: | 2015-07-01 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG.
Chem.Biol., 22, 2015
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4ZDI
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1GPW
 | | Structural evidence for ammonia tunneling across the (beta/alpha)8 barrel of the imidazole glycerol phosphate synthase bienzyme complex. | | Descriptor: | AMIDOTRANSFERASE HISH, HISF PROTEIN, PHOSPHATE ION | | Authors: | Walker, M, Beismann-Driemeyer, S, Sterner, R, Wilmanns, M. | | Deposit date: | 2001-11-12 | | Release date: | 2002-02-10 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural Evidence for Ammonia Tunneling Across the (Beta Alpha)(8) Barrel of the Imidazole Glycerol Phosphate Synthase Bienzyme Complex.
Structure, 10, 2002
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1GPM
 | | ESCHERICHIA COLI GMP SYNTHETASE COMPLEXED WITH AMP AND PYROPHOSPHATE | | Descriptor: | ADENOSINE MONOPHOSPHATE, CITRIC ACID, GMP SYNTHETASE, ... | | Authors: | Tesmer, J.J.G. | | Deposit date: | 1995-04-04 | | Release date: | 1996-01-29 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | The crystal structure of GMP synthetase reveals a novel catalytic triad and is a structural paradigm for two enzyme families.
Nat.Struct.Biol., 3, 1996
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1I1Q
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1I7Q
 | | ANTHRANILATE SYNTHASE FROM S. MARCESCENS | | Descriptor: | ANTHRANILATE SYNTHASE, BENZOIC ACID, GLUTAMIC ACID, ... | | Authors: | Spraggon, G, Kim, C, Nguyen-Huu, X, Yee, M.-C, Yanofsky, C, Mills, S.E. | | Deposit date: | 2001-03-10 | | Release date: | 2001-05-16 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | The structures of anthranilate synthase of Serratia marcescens crystallized in the presence of (i) its substrates, chorismate and glutamine, and a product, glutamate, and (ii) its end-product inhibitor, L-tryptophan.
Proc.Natl.Acad.Sci.USA, 98, 2001
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1I7S
 | | ANTHRANILATE SYNTHASE FROM SERRATIA MARCESCENS IN COMPLEX WITH ITS END PRODUCT INHIBITOR L-TRYPTOPHAN | | Descriptor: | ANTHRANILATE SYNTHASE, TRPG, TRYPTOPHAN | | Authors: | Spraggon, G, Kim, C, Nguyen-Huu, X, Yee, M.-C, Yanofsky, C, Mills, S.E. | | Deposit date: | 2001-03-10 | | Release date: | 2001-05-16 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | The structures of anthranilate synthase of Serratia marcescens crystallized in the presence of (i) its substrates, chorismate and glutamine, and a product, glutamate, and (ii) its end-product inhibitor, L-tryptophan.
Proc.Natl.Acad.Sci.USA, 98, 2001
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4L95
 | | Crystal structure of gamma glutamyl hydrolase (H218N) from zebrafish | | Descriptor: | GLYCEROL, Gamma-glutamyl hydrolase | | Authors: | Chuankhayan, P, Kao, T.-T, Chen, C.-J, Fu, T.-F. | | Deposit date: | 2013-06-18 | | Release date: | 2014-05-14 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.34 Å) | | Cite: | Structural insights into the hydrolysis and polymorphism of methotrexate polyglutamate by zebrafish gamma-glutamyl hydrolase
J.Med.Chem., 56, 2013
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4L8W
 | | Crystal structure of gamma glutamyl hydrolase (H218N) from zebrafish complex with MTX polyglutamate | | Descriptor: | D-GLUTAMIC ACID, Gamma-glutamyl hydrolase, METHOTREXATE | | Authors: | Chuankhayan, P, Kao, T.-T, Chen, C.-J, Fu, T.-F. | | Deposit date: | 2013-06-18 | | Release date: | 2014-05-14 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.39 Å) | | Cite: | Structural insights into the hydrolysis and polymorphism of methotrexate polyglutamate by zebrafish gamma-glutamyl hydrolase
J.Med.Chem., 56, 2013
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4L8Y
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4L8F
 | | Crystal structure of gamma-glutamyl hydrolase (C108A) complex with MTX | | Descriptor: | Gamma-glutamyl hydrolase, METHOTREXATE | | Authors: | Chuankhayan, P, Kao, T.-T, Chen, C.-J, Fu, T.-F. | | Deposit date: | 2013-06-17 | | Release date: | 2014-05-14 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.97 Å) | | Cite: | Structural insights into the hydrolysis and polymorphism of methotrexate polyglutamate by zebrafish gamma-glutamyl hydrolase
J.Med.Chem., 56, 2013
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4L7Q
 | | Crystal structure of gamma glutamyl hydrolase (wild-type) from zebrafish | | Descriptor: | GLYCEROL, Gamma-glutamyl hydrolase | | Authors: | Chuankhayan, P, Kao, T.-T, Chen, C.-J, Fu, T.-F. | | Deposit date: | 2013-06-14 | | Release date: | 2014-05-14 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural insights into the hydrolysis and polymorphism of methotrexate polyglutamate by zebrafish gamma-glutamyl hydrolase
J.Med.Chem., 56, 2013
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5DOU
 | | Crystal Structure of Human Carbamoyl phosphate synthetase I (CPS1), ligand-bound form | | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ... | | Authors: | de Cima, S, Polo, L.M, Fita, I, Rubio, V. | | Deposit date: | 2015-09-11 | | Release date: | 2015-12-09 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structure of human carbamoyl phosphate synthetase: deciphering the on/off switch of human ureagenesis.
Sci Rep, 5, 2015
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5DOT
 | | Crystal Structure of Human Carbamoyl phosphate synthetase I (CPS1), apo form | | Descriptor: | 1,2-ETHANEDIOL, Carbamoyl-phosphate synthase [ammonia], mitochondrial, ... | | Authors: | Polo, L.M, de Cima, S, Fita, I, Rubio, V. | | Deposit date: | 2015-09-11 | | Release date: | 2015-12-09 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structure of human carbamoyl phosphate synthetase: deciphering the on/off switch of human ureagenesis.
Sci Rep, 5, 2015
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1VCO
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1VCM
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1VCN
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1A9X
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5TKV
 | | X-RAY CRYSTAL STRUCTURE OF THE "CLOSED" CONFORMATION OF CTP-INHIBITED E. COLI CYTIDINE TRIPHOSPHATE (CTP) SYNTHETASE | | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, CTP synthase, ... | | Authors: | Baldwin, E.P, Endrizzi, J.A. | | Deposit date: | 2016-10-07 | | Release date: | 2017-04-26 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Human CTP synthase filament structure reveals the active enzyme conformation.
Nat. Struct. Mol. Biol., 24, 2017
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1C30
 | | CRYSTAL STRUCTURE OF CARBAMOYL PHOSPHATE SYNTHETASE: SMALL SUBUNIT MUTATION C269S | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CARBAMOYL PHOSPHATE SYNTHETASE: LARGE SUBUNIT, CARBAMOYL PHOSPHATE SYNTHETASE: SMALL SUBUNIT, ... | | Authors: | Thoden, J.B, Huang, X, Raushel, F.M, Holden, H.M. | | Deposit date: | 1999-07-24 | | Release date: | 1999-12-10 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The small subunit of carbamoyl phosphate synthetase: snapshots along the reaction pathway.
Biochemistry, 38, 1999
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1C3O
 | | CRYSTAL STRUCTURE OF THE CARBAMOYL PHOSPHATE SYNTHETASE: SMALL SUBUNIT MUTANT C269S WITH BOUND GLUTAMINE | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CARBAMOYL PHOSPHATE SYNTHETASE: LARGE SUBUNIT, CARBAMOYL PHOSPHATE SYNTHETASE: SMALL SUBUNIT, ... | | Authors: | Thoden, J.B, Huang, X, Raushel, F.M, Holden, H.M. | | Deposit date: | 1999-07-28 | | Release date: | 1999-12-10 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | The small subunit of carbamoyl phosphate synthetase: snapshots along the reaction pathway.
Biochemistry, 38, 1999
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5U05
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5U03
 | | Cryo-EM structure of the human CTP synthase filament | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CTP synthase 1, URIDINE 5'-TRIPHOSPHATE | | Authors: | Lynch, E.M, Kollman, J.M. | | Deposit date: | 2016-11-22 | | Release date: | 2017-04-26 | | Last modified: | 2018-07-18 | | Method: | ELECTRON MICROSCOPY (6.1 Å) | | Cite: | Human CTP synthase filament structure reveals the active enzyme conformation.
Nat. Struct. Mol. Biol., 24, 2017
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1BXR
 | | STRUCTURE OF CARBAMOYL PHOSPHATE SYNTHETASE COMPLEXED WITH THE ATP ANALOG AMPPNP | | Descriptor: | CARBAMOYL-PHOSPHATE SYNTHASE, CHLORIDE ION, L-ornithine, ... | | Authors: | Thoden, J.B, Wesenberg, G, Raushel, F.M, Holden, H.M. | | Deposit date: | 1998-10-08 | | Release date: | 1999-04-20 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Carbamoyl phosphate synthetase: closure of the B-domain as a result of nucleotide binding.
Biochemistry, 38, 1999
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5U3C
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