4L8F
Crystal structure of gamma-glutamyl hydrolase (C108A) complex with MTX
Summary for 4L8F
| Entry DOI | 10.2210/pdb4l8f/pdb |
| Related | 4L7Q 4L8W 4L8Y 4L95 |
| Descriptor | Gamma-glutamyl hydrolase, METHOTREXATE (3 entities in total) |
| Functional Keywords | sandwiched-like domains, gamma-glutamyl hydrolase, hydrolase |
| Biological source | Danio rerio (zebra fish) |
| Total number of polymer chains | 4 |
| Total formula weight | 142448.47 |
| Authors | Chuankhayan, P.,Kao, T.-T.,Chen, C.-J.,Fu, T.-F. (deposition date: 2013-06-17, release date: 2014-05-14, Last modification date: 2023-11-08) |
| Primary citation | Chuankhayan, P.,Kao, T.-T.,Lin, C.-C.,Guan, H.-H.,Nakagawa, A.,Fu, T.-F.,Chen, C.-J. Structural insights into the hydrolysis and polymorphism of methotrexate polyglutamate by zebrafish gamma-glutamyl hydrolase J.Med.Chem., 56:7625-7635, 2013 Cited by PubMed: 24028568DOI: 10.1021/jm401013e PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.97 Å) |
Structure validation
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