4L8W

Crystal structure of gamma glutamyl hydrolase (H218N) from zebrafish complex with MTX polyglutamate

Summary for 4L8W

Entry DOI	10.2210/pdb4l8w/pdb
Related	4L7Q 4L8F 4L8Y 4L95
Descriptor	Gamma-glutamyl hydrolase, METHOTREXATE, D-GLUTAMIC ACID, ... (4 entities in total)
Functional Keywords	sandwiched-like domain, hydrolase
Biological source	Danio rerio (zebra fish)
Total number of polymer chains	6
Total formula weight	213854.90
Authors	Chuankhayan, P.,Kao, T.-T.,Chen, C.-J.,Fu, T.-F. (deposition date: 2013-06-18, release date: 2014-05-14, Last modification date: 2023-11-08)
Primary citation	Chuankhayan, P.,Kao, T.-T.,Lin, C.-C.,Guan, H.-H.,Nakagawa, A.,Fu, T.-F.,Chen, C.-J. Structural insights into the hydrolysis and polymorphism of methotrexate polyglutamate by zebrafish gamma-glutamyl hydrolase J.Med.Chem., 56:7625-7635, 2013 Cited by PubMed: 24028568 DOI: 10.1021/jm401013e PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.39 Å)

Structure validation