4L8W
Crystal structure of gamma glutamyl hydrolase (H218N) from zebrafish complex with MTX polyglutamate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0008242 | molecular_function | omega peptidase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| D | 0008242 | molecular_function | omega peptidase activity |
| D | 0016787 | molecular_function | hydrolase activity |
| E | 0008242 | molecular_function | omega peptidase activity |
| E | 0016787 | molecular_function | hydrolase activity |
| G | 0008242 | molecular_function | omega peptidase activity |
| G | 0016787 | molecular_function | hydrolase activity |
| I | 0008242 | molecular_function | omega peptidase activity |
| I | 0016787 | molecular_function | hydrolase activity |
| K | 0008242 | molecular_function | omega peptidase activity |
| K | 0016787 | molecular_function | hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE MTX I 301 |
| Chain | Residue |
| I | PHE20 |
| I | GLN170 |
| I | TRP171 |
| I | DGL302 |
| I | DGL303 |
| I | GLY71 |
| I | GLY72 |
| I | GLY73 |
| I | CYS108 |
| I | LEU109 |
| I | GLU112 |
| I | SER168 |
| I | HIS169 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DGL I 302 |
| Chain | Residue |
| I | GLY72 |
| I | SER168 |
| I | LYS221 |
| I | MTX301 |
| I | DGL303 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DGL I 303 |
| Chain | Residue |
| I | SER282 |
| I | ALA283 |
| I | MTX301 |
| I | DGL302 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE MTX G 301 |
| Chain | Residue |
| G | GLY71 |
| G | GLY72 |
| G | GLY73 |
| G | CYS108 |
| G | LEU109 |
| G | GLU112 |
| G | SER168 |
| G | HIS169 |
| G | GLN170 |
| G | TRP171 |
| G | DGL302 |
| G | DGL303 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DGL G 302 |
| Chain | Residue |
| G | GLY72 |
| G | SER168 |
| G | ASN218 |
| G | LYS221 |
| G | MTX301 |
| G | DGL303 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE DGL G 303 |
| Chain | Residue |
| G | TYR29 |
| G | SER282 |
| G | ALA283 |
| G | PHE284 |
| G | MTX301 |
| G | DGL302 |
| G | HOH462 |
