4L8W
Crystal structure of gamma glutamyl hydrolase (H218N) from zebrafish complex with MTX polyglutamate
Functional Information from GO Data
Chain | GOid | namespace | contents |
B | 0008242 | molecular_function | omega peptidase activity |
B | 0016787 | molecular_function | hydrolase activity |
D | 0008242 | molecular_function | omega peptidase activity |
D | 0016787 | molecular_function | hydrolase activity |
E | 0008242 | molecular_function | omega peptidase activity |
E | 0016787 | molecular_function | hydrolase activity |
G | 0008242 | molecular_function | omega peptidase activity |
G | 0016787 | molecular_function | hydrolase activity |
I | 0008242 | molecular_function | omega peptidase activity |
I | 0016787 | molecular_function | hydrolase activity |
K | 0008242 | molecular_function | omega peptidase activity |
K | 0016787 | molecular_function | hydrolase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE MTX I 301 |
Chain | Residue |
I | PHE20 |
I | GLN170 |
I | TRP171 |
I | DGL302 |
I | DGL303 |
I | GLY71 |
I | GLY72 |
I | GLY73 |
I | CYS108 |
I | LEU109 |
I | GLU112 |
I | SER168 |
I | HIS169 |
site_id | AC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DGL I 302 |
Chain | Residue |
I | GLY72 |
I | SER168 |
I | LYS221 |
I | MTX301 |
I | DGL303 |
site_id | AC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DGL I 303 |
Chain | Residue |
I | SER282 |
I | ALA283 |
I | MTX301 |
I | DGL302 |
site_id | AC4 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE MTX G 301 |
Chain | Residue |
G | GLY71 |
G | GLY72 |
G | GLY73 |
G | CYS108 |
G | LEU109 |
G | GLU112 |
G | SER168 |
G | HIS169 |
G | GLN170 |
G | TRP171 |
G | DGL302 |
G | DGL303 |
site_id | AC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE DGL G 302 |
Chain | Residue |
G | GLY72 |
G | SER168 |
G | ASN218 |
G | LYS221 |
G | MTX301 |
G | DGL303 |
site_id | AC6 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE DGL G 303 |
Chain | Residue |
G | TYR29 |
G | SER282 |
G | ALA283 |
G | PHE284 |
G | MTX301 |
G | DGL302 |
G | HOH462 |