4L8W
Crystal structure of gamma glutamyl hydrolase (H218N) from zebrafish complex with MTX polyglutamate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (D, I, B, E, G...) | Gamma-glutamyl hydrolase | polymer | 312 | 35392.9 | 6 | UniProt (Q6NY42) Pfam (PF07722) Pfam (PF00117) | Danio rerio (zebra fish) | |
| 2 | G, J (I, G) | METHOTREXATE | non-polymer | 454.4 | 2 | Chemie (MTX) | |||
| 3 | H, I, K, L (I, G) | D-GLUTAMIC ACID | non-polymer | 147.1 | 4 | Chemie (DGL) | |||
| 4 | M, N, O, P, Q... (D, I, B, E, G...) | water | water | 18.0 | 385 | Chemie (HOH) |
Sequence modifications
D, I, B, E, G, K: -20 - 291 (UniProt: Q6NY42)
| PDB | External Database | Details |
|---|---|---|
| Asn 218 | His 239 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 212357.5 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1497.4 | |
| All* | Total formula weight | 213854.9 |
