4L8F
Crystal structure of gamma-glutamyl hydrolase (C108A) complex with MTX
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (C, D, B, A) | Gamma-glutamyl hydrolase | polymer | 312 | 35384.9 | 4 | UniProt (Q6NY42) Pfam (PF07722) Pfam (PF00117) | Danio rerio (zebra fish) | |
| 2 | E, F (D, B) | METHOTREXATE | non-polymer | 454.4 | 2 | Chemie (MTX) | |||
| 3 | G, H, I, J (C, D, B, A) | water | water | 18.0 | 953 | Chemie (HOH) |
Sequence modifications
C, D, B, A: -20 - 291 (UniProt: Q6NY42)
| PDB | External Database | Details |
|---|---|---|
| Ala 108 | Cys 129 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 141539.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 908.9 | |
| All* | Total formula weight | 142448.5 |
