PDB: 112 resultsInfo pagesStatus searchChemie searchBIRD

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4NQA	Crystal structure of liganded hRXR-alpha/hLXR-beta heterodimer on DNA Descriptor: (9cis)-retinoic acid, 5'-D(*TP*AP*AP*GP*GP*TP*CP*AP*CP*TP*TP*CP*AP*GP*GP*TP*CP*A)-3', 5'-D(*TP*AP*TP*GP*AP*CP*CP*TP*GP*AP*AP*GP*TP*GP*AP*CP*CP*T)-3', ... Authors: Lou, X.H, Toresson, G, Benod, C, Suh, J.H, Phillips, K.J, Webb, P, Gustafsson, J.A. Deposit date: 2013-11-24 Release date: 2014-02-26 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3.102 Å) Cite: Structure of the retinoid X receptor alpha-liver X receptor beta (RXR alpha-LXR beta ) heterodimer on DNA. Nat.Struct.Mol.Biol., 21, 2014
7PRW	The glucocorticoid receptor in complex with velsecorat, a PGC1a coactivator fragment and sgk 23bp Descriptor: 1,2-ETHANEDIOL, DNA (5'-D(*GP*TP*AP*CP*AP*GP*AP*AP*CP*AP*TP*TP*TP*TP*GP*TP*CP*CP*GP*TP*CP*GP*A)-3'), DNA (5'-D(*TP*CP*GP*AP*CP*GP*GP*AP*CP*AP*AP*AP*AP*TP*GP*TP*TP*CP*TP*GP*TP*AP*C)-3'), ... Authors: Postel, S, Edman, K, Wissler, L. Deposit date: 2021-09-22 Release date: 2023-02-08 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.502 Å) Cite: Quaternary glucocorticoid receptor structure highlights allosteric interdomain communication. Nat.Struct.Mol.Biol., 30, 2023
7PRV	The glucocorticoid receptor in complex with fluticasone furoate, a PGC1a coactivator fragment and sgk 23bp Descriptor: (6alpha,11alpha,14beta,16alpha,17alpha)-6,9-difluoro-17-{[(fluoromethyl)sulfanyl]carbonyl}-11-hydroxy-16-methyl-3-oxoan drosta-1,4-dien-17-yl furan-2-carboxylate, 1,2-ETHANEDIOL, DNA (5'-D(*TP*AP*CP*AP*GP*AP*AP*CP*AP*TP*TP*TP*TP*GP*TP*CP*CP*GP*TP*CP*GP*A)-3'), ... Authors: Postel, S, Edman, K, Wissler, L. Deposit date: 2021-09-22 Release date: 2023-02-08 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Quaternary glucocorticoid receptor structure highlights allosteric interdomain communication. Nat.Struct.Mol.Biol., 30, 2023
8FFW	Cryo-EM structure of the GR-Hsp90-FKBP51 complex Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DEXAMETHASONE, Glucocorticoid receptor, ... Authors: Noddings, C.M, Agard, D.A. Deposit date: 2022-12-10 Release date: 2023-11-01 Last modified: 2023-12-20 Method: ELECTRON MICROSCOPY (3.23 Å) Cite: Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the glucocorticoid receptor. Nat.Struct.Mol.Biol., 30, 2023
8FFV	Cryo-EM structure of the GR-Hsp90-FKBP52 complex Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DEXAMETHASONE, Glucocorticoid receptor, ... Authors: Noddings, C.M, Agard, D.A. Deposit date: 2022-12-10 Release date: 2023-11-01 Last modified: 2023-12-20 Method: ELECTRON MICROSCOPY (3.01 Å) Cite: Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the glucocorticoid receptor. Nat.Struct.Mol.Biol., 30, 2023
4IQR	Multi-Domain Organization of the HNF4alpha Nuclear Receptor Complex on DNA Descriptor: DNA (5'-D(*CP*CP*TP*GP*AP*CP*CP*TP*TP*TP*GP*AP*CP*CP*TP*AP*GP*TP*TP*C)-3'), DNA (5'-D(*GP*GP*AP*AP*CP*TP*AP*GP*GP*TP*CP*AP*AP*AP*GP*GP*TP*CP*AP*G)-3'), Hepatocyte nuclear factor 4-alpha, ... Authors: Chandra, V, Huang, P, Kim, Y, Rastinejad, F. Deposit date: 2013-01-13 Release date: 2013-03-20 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Multidomain integration in the structure of the HNF-4 alpha nuclear receptor complex. Nature, 495, 2013
5UAN	Crystal structure of multi-domain RAR-beta-RXR-alpha heterodimer on DNA Descriptor: (9cis)-retinoic acid, DNA (5'-D(*CP*TP*AP*GP*GP*TP*CP*AP*AP*AP*GP*GP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*CP*CP*TP*TP*TP*GP*AP*CP*CP*TP*AP*G)-3'), ... Authors: Chandra, V, Wu, D, Kim, Y, Rastinejad, F. Deposit date: 2016-12-19 Release date: 2017-10-18 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.508 Å) Cite: The quaternary architecture of RAR beta-RXR alpha heterodimer facilitates domain-domain signal transmission. Nat Commun, 8, 2017
6FX0	Structure-based design of Trifarotene (CD5789), a potent and selective RAR gamma agonist for the treatment of acne Descriptor: 6-[3-(1-adamantyl)-4-oxidanyl-phenyl]naphthalene-2-carboxylic acid, Retinoic acid receptor gamma, TETRAETHYLENE GLYCOL Authors: Chantalat, L, Thoreau, E. Deposit date: 2018-03-08 Release date: 2018-05-23 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structure-based design of Trifarotene (CD5789), a potent and selective RAR gamma agonist for the treatment of acne. Bioorg. Med. Chem. Lett., 28, 2018
7WNH	Crystal structure of Nurr1 binding to NBRE Descriptor: DNA (5'-D(*CP*CP*GP*AP*AP*AP*AP*GP*GP*TP*CP*AP*TP*GP*CP*G)-3'), DNA (5'-D(*CP*GP*CP*AP*TP*GP*AP*CP*CP*TP*TP*TP*TP*CP*GP*G)-3'), Nuclear receptor subfamily 4 group A member 2, ... Authors: Zhao, M, Xu, T, Wang, N, Guo, Y, Liu, J. Deposit date: 2022-01-18 Release date: 2023-01-25 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Integrative analysis reveals structural basis for transcription activation of Nurr1 and Nurr1-RXR alpha heterodimer. Proc.Natl.Acad.Sci.USA, 119, 2022
3DZU	Intact PPAR gamma - RXR alpha Nuclear Receptor Complex on DNA bound with BVT.13, 9-cis Retinoic Acid and NCOA2 Peptide Descriptor: (9cis)-retinoic acid, 2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID, DNA (5'-D(*DCP*DAP*DAP*DAP*DCP*DTP*DAP*DGP*DGP*DTP*DCP*DAP*DAP*DAP*DGP*DGP*DTP*DCP*DAP*DG)-3'), ... Authors: Chandra, V, Huang, P, Hamuro, Y, Raghuram, S, Wang, Y, Burris, T.P, Rastinejad, F. Deposit date: 2008-07-30 Release date: 2008-10-28 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA. Nature, 456, 2008
3E00	Intact PPAR gamma - RXR alpha Nuclear Receptor Complex on DNA bound with GW9662, 9-cis Retinoic Acid and NCOA2 Peptide Descriptor: (9cis)-retinoic acid, 2-chloro-5-nitro-N-phenylbenzamide, DNA (5'-D(*DCP*DAP*DAP*DAP*DCP*DTP*DAP*DGP*DGP*DTP*DCP*DAP*DAP*DAP*DGP*DGP*DTP*DCP*DAP*DG)-3'), ... Authors: Chandra, V, Huang, P, Hamuro, Y, Raghuram, S, Wang, Y, Burris, T.P, Rastinejad, F. Deposit date: 2008-07-30 Release date: 2008-10-28 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA. Nature, 456, 2008
3DZY	Intact PPAR gamma - RXR alpha Nuclear Receptor Complex on DNA bound with Rosiglitazone, 9-cis Retinoic Acid and NCOA2 Peptide Descriptor: (9cis)-retinoic acid, 2,4-THIAZOLIDIINEDIONE, 5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-(9CL), ... Authors: Chandra, V, Huang, P, Hamuro, Y, Raghuram, S, Wang, Y, Burris, T.P, Rastinejad, F. Deposit date: 2008-07-30 Release date: 2008-10-28 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA. Nature, 456, 2008

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