7PRW
The glucocorticoid receptor in complex with velsecorat, a PGC1a coactivator fragment and sgk 23bp
Summary for 7PRW
Entry DOI | 10.2210/pdb7prw/pdb |
Descriptor | Glucocorticoid receptor, DNA (5'-D(*TP*CP*GP*AP*CP*GP*GP*AP*CP*AP*AP*AP*AP*TP*GP*TP*TP*CP*TP*GP*TP*AP*C)-3'), DNA (5'-D(*GP*TP*AP*CP*AP*GP*AP*AP*CP*AP*TP*TP*TP*TP*GP*TP*CP*CP*GP*TP*CP*GP*A)-3'), ... (8 entities in total) |
Functional Keywords | nuclear receptor, ligand-activated transcription factor, multi-domain, complex, agonist, signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 5 |
Total formula weight | 107251.96 |
Authors | Postel, S.,Edman, K.,Wissler, L. (deposition date: 2021-09-22, release date: 2023-02-08, Last modification date: 2024-02-07) |
Primary citation | Postel, S.,Wissler, L.,Johansson, C.A.,Gunnarsson, A.,Gordon, E.,Collins, B.,Castaldo, M.,Kohler, C.,Oling, D.,Johansson, P.,Froderberg Roth, L.,Beinsteiner, B.,Dainty, I.,Delaney, S.,Klaholz, B.P.,Billas, I.M.L.,Edman, K. Quaternary glucocorticoid receptor structure highlights allosteric interdomain communication. Nat.Struct.Mol.Biol., 30:286-295, 2023 Cited by PubMed: 36747092DOI: 10.1038/s41594-022-00914-4 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.502 Å) |
Structure validation
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