7PRW

The glucocorticoid receptor in complex with velsecorat, a PGC1a coactivator fragment and sgk 23bp

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Glucocorticoid receptor	polymer	393	44511.5	2	UniProt (P04150) Pfam (PF00105) Pfam (PF00104)	Homo sapiens (Human)	GR,Nuclear receptor subfamily 3 group C member 1
2	C (C)	DNA (5'-D(*TP*CP*GP*AP*CP*GP*GP*AP*CP*AP*AP*AP*AP*TP*GP*TP*TP*CP*TP*GP*TP*AP*C)-3')	polymer	23	7064.6	1		Homo sapiens
3	D (D)	DNA (5'-D(*GP*TP*AP*CP*AP*GP*AP*AP*CP*AP*TP*TP*TP*TP*GP*TP*CP*CP*GP*TP*CP*GP*A)-3')	polymer	23	7055.6	1		Homo sapiens
4	E (F)	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha	polymer	21	2261.6	1	UniProt (Q9UBK2)	Homo sapiens	PGC-1-alpha,PPAR-gamma coactivator 1-alpha,PPARGC-1-alpha,Ligand effect modulator 6, PGC1a coactivator fragment
5	F, G, K, L (A, B)	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
6	H, J, M, N, O... (A, B, D)	1,2-ETHANEDIOL	non-polymer		62.1	6	Chemie (EDO)
7	I, P (A, B)	Velsecorat	non-polymer		606.6	2	Chemie (82H)
8	R, S, T, U (A, B, C, D)	water	water		18.0	64	Chemie (HOH)

Sequence modifications

A, B: 385 - 777 (UniProt: P04150)

PDB	External Database	Details
Ala 404	Ser 404	engineered mutation
Asp 517	Asn 517	engineered mutation
Met 571	Val 571	engineered mutation
Ser 602	Phe 602	engineered mutation
Asp 638	Cys 638	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	105404.7
Non-Polymers*	Number of molecules	12
	Total formula weight	1847.3
All*	Total formula weight	107252.0

*Water molecules are not included.