7PRW

The glucocorticoid receptor in complex with velsecorat, a PGC1a coactivator fragment and sgk 23bp

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0006355	biological_process	regulation of DNA-templated transcription
A	0008270	molecular_function	zinc ion binding
A	0043565	molecular_function	sequence-specific DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0006355	biological_process	regulation of DNA-templated transcription
B	0008270	molecular_function	zinc ion binding
B	0043565	molecular_function	sequence-specific DNA binding

Functional Information from PROSITE/UniProt

site_id	PS00031
Number of Residues	27
Details	NUCLEAR_REC_DBD_1 Nuclear hormones receptors DNA-binding region signature. ClvCs.Deasgc.HYgvltCgsCkvFFkR

Chain	Residue	Details
A	CYS421-ARG447

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:O70343

Chain	Residue	Details
F	LYS146
B	PRO418-THR493

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site_id	SWS_FT_FI2
Number of Residues	78
Details	ZN_FING: NR C4-type => ECO:0000255|PROSITE-ProRule:PRU00407

Chain	Residue	Details
A	CYS421-CYS441
A	CYS457-CYS476
B	CYS421-CYS441
B	CYS457-CYS476

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine; by GSK3-beta => ECO:0000269|PubMed:18838540

Chain	Residue	Details
A	ALA404
B	ALA404

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site_id	SWS_FT_FI4
Number of Residues	8
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:19141540

Chain	Residue	Details
A	LYS480
A	LYS492
A	LYS494
A	LYS495
B	LYS480
B	LYS492
B	LYS494
B	LYS495

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site_id	SWS_FT_FI5
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P06537

Chain	Residue	Details
A	LYS419
B	LYS419

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site_id	SWS_FT_FI6
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:12144530

Chain	Residue	Details
A	LYS703
B	LYS703

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