3E00

Intact PPAR gamma - RXR alpha Nuclear Receptor Complex on DNA bound with GW9662, 9-cis Retinoic Acid and NCOA2 Peptide

Summary for 3E00

Related3DZU 3DZY
DescriptorRetinoic acid receptor RXR-alpha, Peroxisome proliferator-activated receptor gamma, DNA (5'-D(*DCP*DAP*DAP*DAP*DCP*DTP*DAP*DGP*DGP*DTP*DCP*DAP*DAP*DAP*DGP*DGP*DTP*DCP*DAP*DG)-3'), ... (8 entities in total)
Functional Keywordsdna-binding, host-virus interaction, metal-binding, nucleus, receptor, transcription, transcription regulation, zinc-finger, activator, diabetes mellitus, disease mutation, obesity, phosphoprotein, transcription-dna complex, transcription/dna
Biological sourceHomo sapiens (Human)
More
Cellular locationNucleus  P19793 P37231 Q15596
Total number of polymer chains6
Total molecular weight116041.03
Authors
Chandra, V.,Huang, P.,Hamuro, Y.,Raghuram, S.,Wang, Y.,Burris, T.P.,Rastinejad, F. (deposition date: 2008-07-30, release date: 2008-10-28, Last modification date: 2017-10-25)
Primary citation
Chandra, V.,Huang, P.,Hamuro, Y.,Raghuram, S.,Wang, Y.,Burris, T.P.,Rastinejad, F.
Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA.
Nature, 456:350-356, 2008
PubMed: 19043829 (PDB entries with the same primary citation)
DOI: 10.1038/nature07413
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.1 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.276354.0%4.4%2.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report