PDB: 729 件ウェブページステータス検索Chemie searchBIRD

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4ZN5	YopH W354Y Yersinia enterocolitica PTPase bond with Divanadate glycerol ester in the active site 分子名称: ACETATE ION, Divanadate Glycerol ester, GLYCEROL, ... 著者 Moise, G.E, Johnson, S.J, Hengge, A.C. 登録日 2015-05-04 公開日 2015-10-28 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.12 Å) 主引用文献 Conservative Tryptophan Mutants of the Protein Tyrosine Phosphatase YopH Exhibit Impaired WPD-Loop Function and Crystallize with Divanadate Esters in Their Active Sites. Biochemistry, 54, 2015
4ZRT	PTP1BC215S bound to Nephrin peptide substrate 分子名称: CHLORIDE ION, GLY-PRO-LEU-PTR-ASP-GLU, GLYCEROL, ... 著者 Selner, N.G, Bell, C.E, Pei, D. 登録日 2015-05-12 公開日 2015-06-24 最終更新日 2019-12-25 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 Diverse levels of sequence selectivity and catalytic efficiency of protein-tyrosine phosphatases. Biochemistry, 53, 2014
5BUG	Crystal structure of human phosphatase PTEN oxidized by H2O2 分子名称: L(+)-TARTARIC ACID, Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN 著者 Lee, C.-U, Bier, D, Hennig, S, Grossmann, T.N. 登録日 2015-06-03 公開日 2015-10-07 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Redox Modulation of PTEN Phosphatase Activity by Hydrogen Peroxide and Bisperoxidovanadium Complexes. Angew.Chem.Int.Ed.Engl., 54, 2015
5BZX	Crystal structure of human phosphatase PTEN treated with a bisperoxovanadium complex 分子名称: L(+)-TARTARIC ACID, Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, VANADATE ION 著者 Lee, C.-U, Bier, D, Hennig, S, Grossmann, T.N. 登録日 2015-06-11 公開日 2015-10-07 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Redox Modulation of PTEN Phosphatase Activity by Hydrogen Peroxide and Bisperoxidovanadium Complexes. Angew.Chem.Int.Ed.Engl., 54, 2015
5BZZ	Crystal structure of human phosphatase PTEN in its reduced state 分子名称: L(+)-TARTARIC ACID, Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN 著者 Lee, C.-U, Bier, D, Hennig, S, Grossmann, T.N. 登録日 2015-06-11 公開日 2015-10-07 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Redox Modulation of PTEN Phosphatase Activity by Hydrogen Peroxide and Bisperoxidovanadium Complexes. Angew.Chem.Int.Ed.Engl., 54, 2015
5AWX	Crystal structure of Human PTPRZ D1 domain 分子名称: BROMIDE ION, Receptor-type tyrosine-protein phosphatase zeta 著者 Sugawara, H. 登録日 2015-07-10 公開日 2016-02-17 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 Small-molecule inhibition of PTPRZ reduces tumor growth in a rat model of glioblastoma Sci Rep, 6, 2016
5EHR	Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor SHP099 分子名称: 6-(4-azanyl-4-methyl-piperidin-1-yl)-3-[2,3-bis(chloranyl)phenyl]pyrazin-2-amine, PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 11 著者 Stams, T, Fodor, M. 登録日 2015-10-28 公開日 2016-06-29 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases. Nature, 535, 2016
5EHP	Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor SHP836 分子名称: 5-[2,3-bis(chloranyl)phenyl]-2-[(3~{R},5~{S})-3,5-dimethylpiperazin-1-yl]pyrimidin-4-amine, PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 11 著者 Stams, T, Fodor, M. 登録日 2015-10-28 公開日 2016-07-06 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor. J.Med.Chem., 59, 2016
5HDE	Crystal Structure of PTPN12 Catalytic Domain 分子名称: PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 12 著者 Dong, H, Li, S, Shi, J. 登録日 2016-01-05 公開日 2017-01-18 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.62 Å) 主引用文献 Crystal Structure of PTPN12 Catalytic Domain To Be Published
5I6V	Structure of F285S, a Cancer-Associated Mutation of the Oncogenic Phosphatase SHP2 分子名称: GLYCEROL, Tyrosine-protein phosphatase non-receptor type 11 著者 Xu, X, Blacklow, S.C. 登録日 2016-02-16 公開日 2016-04-13 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Structural and Functional Consequences of Three Cancer-Associated Mutations of the Oncogenic Phosphatase SHP2. Biochemistry, 55, 2016
5IBM	Structure of S502P, a Cancer-Associated Mutation of the Oncogenic Phosphatase SHP2 分子名称: Tyrosine-protein phosphatase non-receptor type 11 著者 Blacklow, S.C, Stams, T, Fodor, M, LaRochelle, J.R. 登録日 2016-02-22 公開日 2016-04-13 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.18 Å) 主引用文献 Structural and Functional Consequences of Three Cancer-Associated Mutations of the Oncogenic Phosphatase SHP2. Biochemistry, 55, 2016
5IBS	Structure of E76Q, a Cancer-Associated Mutation of the Oncogenic Phosphatase SHP2 分子名称: Tyrosine-protein phosphatase non-receptor type 11 著者 Blacklow, S.C, Stams, T, Fodor, M, LaRochelle, J.R. 登録日 2016-02-22 公開日 2016-04-13 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.32 Å) 主引用文献 Structural and Functional Consequences of Three Cancer-Associated Mutations of the Oncogenic Phosphatase SHP2. Biochemistry, 55, 2016
5J8R	Crystal Structure of the Catalytic Domain of Human Protein Tyrosine Phosphatase non-receptor Type 12 - K61R mutant 分子名称: Tyrosine-protein phosphatase non-receptor type 12 著者 Li, H, Yang, F, Xu, Y.F, Wang, W.J, Xiao, P, Yu, X, Sun, J.P. 登録日 2016-04-08 公開日 2016-04-27 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.043 Å) 主引用文献 Crystal structure and substrate specificity of PTPN12. Cell Rep, 15, 2016
5K24	Crystal structure of the complex between phosphatase PRL-2 in the oxidized state with the Bateman domain of murine magnesium transporter CNNM3 分子名称: CITRATE ANION, Metal transporter CNNM3, Protein tyrosine phosphatase type IVA 2 著者 Kozlov, G, Gulerez, I, Gehring, K. 登録日 2016-05-18 公開日 2016-10-12 最終更新日 2018-10-03 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 PRL3 phosphatase active site is required for binding the putative magnesium transporter CNNM3. Sci Rep, 7, 2017
5K25	Crystal structure of human phosphatase PRL-2 in complex with the ADP-bound Bateman domain of human magnesium transporter CNNM3 分子名称: ADENOSINE-5'-DIPHOSPHATE, Metal transporter CNNM3, Protein tyrosine phosphatase type IVA 2 著者 Gulerez, I, Kozlov, G, Gehring, K. 登録日 2016-05-18 公開日 2016-10-12 最終更新日 2018-10-03 実験手法 X-RAY DIFFRACTION (3.05 Å) 主引用文献 PRL3 phosphatase active site is required for binding the putative magnesium transporter CNNM3. Sci Rep, 7, 2017
5K22	Crystal structure of the complex between human PRL-2 phosphatase in reduced state and Bateman domain of human CNNM3 分子名称: Metal transporter CNNM3, Protein tyrosine phosphatase type IVA 2 著者 Kozlov, G, Wu, H, Gehring, K. 登録日 2016-05-18 公開日 2016-10-12 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Phosphocysteine in the PRL-CNNM pathway mediates magnesium homeostasis. EMBO Rep., 17, 2016
5K23	Crystal structure of the complex between human phosphatase PRL-2 in the oxidized state with the Bateman domain of human magnesium transporter CNNM3 分子名称: Metal transporter CNNM3, Protein tyrosine phosphatase type IVA 2 著者 Gulerez, I, Kozlov, G, Gehring, K. 登録日 2016-05-18 公開日 2016-10-12 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.96 Å) 主引用文献 PRL3 phosphatase active site is required for binding the putative magnesium transporter CNNM3. Sci Rep, 7, 2017
5KA8	Protein Tyrosine Phosphatase 1B L192A mutant, open state 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, Tyrosine-protein phosphatase non-receptor type 1 著者 Choy, M.S, Peti, W, Page, R. 登録日 2016-06-01 公開日 2017-03-01 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.971 Å) 主引用文献 Conformational Rigidity and Protein Dynamics at Distinct Timescales Regulate PTP1B Activity and Allostery. Mol. Cell, 65, 2017
5KA9	Protein Tyrosine Phosphatase 1B L192A mutant in complex with TCS401, open state 分子名称: 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ... 著者 Choy, M.S, Peti, W, Page, R. 登録日 2016-06-01 公開日 2017-03-01 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 Conformational Rigidity and Protein Dynamics at Distinct Timescales Regulate PTP1B Activity and Allostery. Mol. Cell, 65, 2017
5K9W	Protein Tyrosine Phosphatase 1B (1-301) in complex with TCS401, closed state 分子名称: 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ... 著者 Choy, M.S, Peti, W, Page, R. 登録日 2016-06-01 公開日 2017-03-01 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Conformational Rigidity and Protein Dynamics at Distinct Timescales Regulate PTP1B Activity and Allostery. Mol. Cell, 65, 2017
5KA7	Protein Tyrosine Phosphatase 1B T178A mutant in complex with TCS401, closed state 分子名称: 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ... 著者 Choy, M.S, Peti, W, Page, R. 登録日 2016-06-01 公開日 2017-03-08 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.061 Å) 主引用文献 Conformational Rigidity and Protein Dynamics at Distinct Timescales Regulate PTP1B Activity and Allostery. Mol. Cell, 65, 2017
5KA0	Protein Tyrosine Phosphatase 1B Delta helix 7, open state 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, GLYCEROL, ... 著者 Choy, M.S, Peti, W, Page, R. 登録日 2016-06-01 公開日 2017-03-01 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.991 Å) 主引用文献 Conformational Rigidity and Protein Dynamics at Distinct Timescales Regulate PTP1B Activity and Allostery. Mol. Cell, 65, 2017
5KAD	Protein Tyrosine Phosphatase 1B N193A mutant in complex with TCS401, closed state 分子名称: 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ... 著者 Choy, M.S, Peti, W, Page, R. 登録日 2016-06-01 公開日 2017-03-01 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Conformational Rigidity and Protein Dynamics at Distinct Timescales Regulate PTP1B Activity and Allostery. Mol. Cell, 65, 2017
5K9V	Protein Tyrosine Phosphatase 1B (1-301), open state 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, GLYCEROL, ... 著者 Choy, M.S, Peti, W, Page, R. 登録日 2016-06-01 公開日 2017-03-01 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.898 Å) 主引用文献 Conformational Rigidity and Protein Dynamics at Distinct Timescales Regulate PTP1B Activity and Allostery. Mol. Cell, 65, 2017
5KAA	Protein Tyrosine Phosphatase 1B Delta helix 7, P185G mutant, open state 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, GLYCEROL, ... 著者 Choy, M.S, Machado, L.E.S.F, Peti, W, Page, R. 登録日 2016-06-01 公開日 2017-03-08 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.968 Å) 主引用文献 Conformational Rigidity and Protein Dynamics at Distinct Timescales Regulate PTP1B Activity and Allostery. Mol. Cell, 65, 2017

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