PDB: 291 件ウェブページステータス検索Chemie searchBIRD

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6V9W	Structure of TRPA1 (ligand-free) with bound calcium, LMNG 分子名称: CALCIUM ION, Transient receptor potential cation channel subfamily A member 1 著者 Zhao, J, Lin King, J.V, Paulsen, C.E, Cheng, Y, Julius, D. 登録日 2019-12-16 公開日 2020-05-06 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Irritant-evoked activation and calcium modulation of the TRPA1 receptor. Nature, 585, 2020
7K4B	Cryo-EM structure of human TRPV6 in complex with (4- phenylcyclohexyl)piperazine inhibitor cis-22a 分子名称: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-[cis-4-(3-methylphenyl)cyclohexyl]-4-(pyridin-3-yl)piperazine, CALCIUM ION, ... 著者 Neuberger, A, Nadezhdin, K.D, Singh, A.K, Sobolevsky, A.I. 登録日 2020-09-15 公開日 2020-12-09 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Inactivation-mimicking block of the epithelial calcium channel TRPV6. Sci Adv, 6, 2020
7RQW	Cryo-EM structure of the full-length TRPV1 with RTx at 4 degrees Celsius, in an open state, class III 分子名称: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Transient receptor potential cation channel subfamily V member 1, ... 著者 Kwon, D.H, Suo, Y, Lee, S.-Y. 登録日 2021-08-08 公開日 2022-06-01 実験手法 ELECTRON MICROSCOPY (3.11 Å) 主引用文献 Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis. Nat Commun, 13, 2022
7MIK	Mouse TRPV3 in MSP2N2 nanodiscs, closed state at 42 degrees Celsius 分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SODIUM ION, Transient receptor potential cation channel subfamily V member 3 著者 Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. 登録日 2021-04-17 公開日 2021-07-21 最終更新日 2021-07-28 実験手法 ELECTRON MICROSCOPY (3.12 Å) 主引用文献 Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel. Nat.Struct.Mol.Biol., 28, 2021
2FO1	Crystal Structure of the CSL-Notch-Mastermind ternary complex bound to DNA 分子名称: 5'-D(*AP*AP*TP*CP*TP*TP*TP*CP*CP*CP*AP*CP*AP*GP*T)-3', 5'-D(*TP*TP*AP*CP*TP*GP*TP*GP*GP*GP*AP*AP*AP*GP*A)-3', Lin-12 and glp-1 phenotype protein 1, ... 著者 Wilson, J.J, Kovall, R.A. 登録日 2006-01-12 公開日 2006-03-21 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (3.12 Å) 主引用文献 Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA. Cell(Cambridge,Mass.), 124, 2006
7B16	TRPC4 in complex with inhibitor GFB-9289 分子名称: 2-(HEXADECANOYLOXY)-1-[(PHOSPHONOOXY)METHYL]ETHYL HEXADECANOATE, 5-chloranyl-4-(4-cyclohexyl-3-oxidanylidene-piperazin-1-yl)-1~{H}-pyridazin-6-one, CALCIUM ION, ... 著者 Vinayagam, D, Quentin, D, Sistel, O, Merino, F, Stabrin, M, Hofnagel, O, Ledeboer, M.W, Malojcic, G, Raunser, S. 登録日 2020-11-23 公開日 2020-12-09 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (3.15 Å) 主引用文献 Structural basis of TRPC4 regulation by calmodulin and pharmacological agents. Elife, 9, 2020
7X6C	Cryo-EM structure of the human TRPC5 ion channel in lipid nanodiscs, class1 分子名称: (2S)-2-(hexadecanoyloxy)-3-hydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CALCIUM ION, ... 著者 Won, J, Jeong, H, Lee, H.H. 登録日 2022-03-07 公開日 2023-05-24 実験手法 ELECTRON MICROSCOPY (3.15 Å) 主引用文献 Molecular architecture of the G alpha i -bound TRPC5 ion channel. Nat Commun, 14, 2023
7L2W	cryo-EM structure of RTX-bound minimal TRPV1 with NMDG at state a 分子名称: (10R,13S)-16-amino-13-hydroxy-7,13-dioxo-8,12,14-trioxa-13lambda~5~-phosphahexadecan-10-yl hexadecanoate, SODIUM ION, Transient receptor potential cation channel subfamily V member 1, ... 著者 Zhang, K, Julius, D, Cheng, Y. 登録日 2020-12-17 公開日 2021-09-22 最終更新日 2021-10-13 実験手法 ELECTRON MICROSCOPY (3.16 Å) 主引用文献 Structural snapshots of TRPV1 reveal mechanism of polymodal functionality. Cell, 184, 2021
7UGG	Cryo-EM structure of TRPV3 in complex with the anesthetic dyclonine 分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Dyclonine, SODIUM ION, ... 著者 Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. 登録日 2022-03-24 公開日 2022-06-08 最終更新日 2024-02-14 実験手法 ELECTRON MICROSCOPY (3.16 Å) 主引用文献 Structural mechanism of TRPV3 channel inhibition by the anesthetic dyclonine. Nat Commun, 13, 2022
3UI2	Crystal structure of the cpSRP54 tail bound to cpSRP43 分子名称: Signal recognition particle 43 kDa protein, chloroplastic, Signal recognition particle 54 kDa protein 著者 Holdermann, I, Wild, K, Sinning, I. 登録日 2011-11-04 公開日 2012-01-11 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (3.178 Å) 主引用文献 Chromodomains read the arginine code of post-translational targeting. Nat.Struct.Mol.Biol., 19, 2012
7MZ9	Cryo-EM structure of minimal TRPV1 with 1 partially bound RTX 分子名称: (2S)-1-(butanoyloxy)-3-{[(R)-hydroxy{[(1r,2R,3S,4S,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propan-2-yl tridecanoate, SODIUM ION, Transient receptor potential cation channel subfamily V member 1, ... 著者 Zhang, K, Julius, D, Cheng, Y. 登録日 2021-05-24 公開日 2021-09-22 最終更新日 2021-10-13 実験手法 ELECTRON MICROSCOPY (3.18 Å) 主引用文献 Structural snapshots of TRPV1 reveal mechanism of polymodal functionality. Cell, 184, 2021
7LQY	Structure of squirrel TRPV1 in apo state 分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoinositol, CHLORIDE ION, ... 著者 Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. 登録日 2021-02-15 公開日 2021-04-21 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.19 Å) 主引用文献 Extracellular cap domain is an essential component of the TRPV1 gating mechanism. Nat Commun, 12, 2021
6MHS	Structure of the human TRPV3 channel in a putative sensitized conformation 分子名称: Transient receptor potential cation channel subfamily V member 3 著者 Zubcevic, L, Herzik, M.A, Wu, M, Borschel, W.F, Hirschi, M, Song, A, Lander, G.C, Lee, S.Y. 登録日 2018-09-18 公開日 2018-10-03 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Conformational ensemble of the human TRPV3 ion channel. Nat Commun, 9, 2018
7T6J	Cryo-EM structure of TRPV5 at pH8 in nanodiscs 分子名称: Transient receptor potential cation channel subfamily V member 5 著者 Fluck, E.C, Yazici, A.T, Rohacs, T, Moiseenkova-Bell, V.Y. 登録日 2021-12-14 公開日 2022-05-04 最終更新日 2024-02-28 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structural basis of TRPV5 regulation by physiological and pathophysiological modulators. Cell Rep, 39, 2022
5JHQ	ARCs 1-3 of human Tankyrase-1 bound to a peptide derived from IRAP 分子名称: Peptide derived from insulin-responsive aminopeptidase (IRAP), Tankyrase-1 著者 Eisemann, T, Pascal, J.M. 登録日 2016-04-21 公開日 2016-09-21 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Tankyrase-1 Ankyrin Repeats Form an Adaptable Binding Platform for Targets of ADP-Ribose Modification. Structure, 24, 2016
2NYJ	Crystal structure of the ankyrin repeat domain of TRPV1 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Transient receptor potential cation channel subfamily V member 1 著者 Jin, X, Gaudet, R. 登録日 2006-11-20 公開日 2007-07-03 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 The Ankyrin Repeats of TRPV1 Bind Multiple Ligands and Modulate Channel Sensitivity. Neuron, 54, 2007
8FHI	Wildtype rabbit TRPV5 in nanodiscs in complex with oleoyl coenzyme A, Open stated 分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ERGOSTEROL, S-{(3R,5R,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9Z)-octadec-9-enethioate (non-preferred name), ... 著者 De Jesus-Perez, J.J, Moiseenkova-Bell, V.Y. 登録日 2022-12-14 公開日 2023-11-01 実験手法 ELECTRON MICROSCOPY (3.25 Å) 主引用文献 Structural basis of the activation of TRPV5 channels by long-chain acyl-Coenzyme-A. Nat Commun, 14, 2023
7L2X	cryo-EM structure of RTX-bound minimal TRPV1 with NMDG at state c 分子名称: (10R,13S)-16-amino-13-hydroxy-7,13-dioxo-8,12,14-trioxa-13lambda~5~-phosphahexadecan-10-yl hexadecanoate, 1-deoxy-1-(methylamino)-D-allitol, Transient receptor potential cation channel subfamily V member 1, ... 著者 Zhang, K, Julius, D, Cheng, Y. 登録日 2020-12-17 公開日 2021-09-22 最終更新日 2021-10-13 実験手法 ELECTRON MICROSCOPY (3.26 Å) 主引用文献 Structural snapshots of TRPV1 reveal mechanism of polymodal functionality. Cell, 184, 2021
7K4A	Cryo-EM structure of human TRPV6 in the open state 分子名称: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CALCIUM ION, CHOLESTEROL HEMISUCCINATE, ... 著者 Neuberger, A, Nadezhdin, K.D, Singh, A.K, Sobolevsky, A.I. 登録日 2020-09-15 公開日 2020-12-09 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.26 Å) 主引用文献 Inactivation-mimicking block of the epithelial calcium channel TRPV6. Sci Adv, 6, 2020
3J5P	Structure of TRPV1 ion channel determined by single particle electron cryo-microscopy 分子名称: Transient receptor potential cation channel subfamily V member 1 著者 Liao, M, Cao, E, Julius, D, Cheng, Y. 登録日 2013-10-28 公開日 2013-12-04 最終更新日 2024-02-21 実験手法 ELECTRON MICROSCOPY (3.275 Å) 主引用文献 Structure of the TRPV1 ion channel determined by electron cryo-microscopy. Nature, 504, 2013
3J9J	Structure of the capsaicin receptor, TRPV1, determined by single particle electron cryo-microscopy 分子名称: Transient receptor potential cation channel subfamily V member 1 著者 Wang, R.Y.-R, Barad, B.A, Fraser, J.S, DiMaio, F. 登録日 2015-02-02 公開日 2015-09-02 最終更新日 2024-02-21 実験手法 ELECTRON MICROSCOPY (3.275 Å) 主引用文献 EMRinger: side chain-directed model and map validation for 3D cryo-electron microscopy. Nat.Methods, 12, 2015
6JZO	Structure of the mouse TRPC4 ion channel 分子名称: 2-(HEXADECANOYLOXY)-1-[(PHOSPHONOOXY)METHYL]ETHYL HEXADECANOATE, CHOLESTEROL HEMISUCCINATE, SODIUM ION, ... 著者 Duan, J, Li, Z, Li, J, Zhang, J. 登録日 2019-05-03 公開日 2020-10-21 最終更新日 2021-05-05 実験手法 ELECTRON MICROSCOPY (3.28 Å) 主引用文献 Structure of the mouse TRPC4 ion channel To Be Published
5Z96	Structure of the mouse TRPC4 ion channel 分子名称: 2-(HEXADECANOYLOXY)-1-[(PHOSPHONOOXY)METHYL]ETHYL HEXADECANOATE, CHOLESTEROL HEMISUCCINATE, SODIUM ION, ... 著者 Duan, J, Li, Z, Li, J, Zhang, J. 登録日 2018-02-02 公開日 2018-04-18 最終更新日 2018-08-29 実験手法 ELECTRON MICROSCOPY (3.28 Å) 主引用文献 Structure of the mouse TRPC4 ion channel. Nat Commun, 9, 2018
5IRZ	Structure of TRPV1 determined in lipid nanodisc 分子名称: (2S)-1-{[(R)-hydroxy{[(1R,2R,3S,4S,5S,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}-3-(pentanoyloxy)propan-2-yl decanoate, (2S)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(hexanoyloxy)propyl hexanoate, (4R,7S)-4-hydroxy-N,N,N-trimethyl-4,9-dioxo-7-[(pentanoyloxy)methyl]-3,5,8-trioxa-4lambda~5~-phosphatetradecan-1-aminium, ... 著者 Gao, Y, Cao, E, Julius, D, Cheng, Y. 登録日 2016-03-15 公開日 2016-05-25 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.28 Å) 主引用文献 TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action. Nature, 534, 2016
7L2R	Cryo-EM structure of DkTx-bound minimal TRPV1 at the pre-open state 分子名称: (2S)-1-(butanoyloxy)-3-{[(R)-hydroxy{[(1r,2R,3S,4S,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propan-2-yl tridecanoate, (9R,12R)-15-amino-12-hydroxy-6,12-dioxo-7,11,13-trioxa-12lambda~5~-phosphapentadecan-9-yl undecanoate, SODIUM ION, ... 著者 Zhang, K, Julius, D, Cheng, Y. 登録日 2020-12-17 公開日 2021-09-22 最終更新日 2021-10-13 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structural snapshots of TRPV1 reveal mechanism of polymodal functionality. Cell, 184, 2021

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