3UI2

Crystal structure of the cpSRP54 tail bound to cpSRP43

Summary for 3UI2

• Entry DOI: 10.2210/pdb3ui2/pdb
• Related: 3deo 3dep
• Descriptor: Signal recognition particle 43 kDa protein, chloroplastic, Signal recognition particle 54 kDa protein, chloroplastic (2 entities in total)
• Functional Keywords: ankyrin repeat, chromodomain, aromatic cage, signal recognition particle, protein targeting, membrane protein chaperone, chloroplast, transport protein
• Biological source: Arabidopsis thaliana (mouse-ear cress,thale-cress); More
• Cellular location: Plastid, chloroplast stroma: O22265 P37107
• Total number of polymer chains: 2
• Total formula weight: 28337.81

Authors

Holdermann, I.,Wild, K.,Sinning, I. (deposition date: 2011-11-04, release date: 2012-01-11, Last modification date: 2023-09-13)

Primary citation

Holdermann, I.,Meyer, N.H.,Round, A.,Wild, K.,Sattler, M.,Sinning, I.
Chromodomains read the arginine code of post-translational targeting.
Nat.Struct.Mol.Biol., 19:260-263, 2012

PubMed Abstract: Chromodomains typically recruit protein complexes to chromatin and read the epigenetic histone code by recognizing lysine methylation in histone tails. We report the crystal structure of the chloroplast signal recognition particle (cpSRP) core from Arabidopsis thaliana, with the cpSRP54 tail comprising an arginine-rich motif bound to the second chromodomain of cpSRP43. A twinned aromatic cage reads out two neighboring nonmethylated arginines and adapts chromodomains to a non-nuclear function in post-translational targeting.

PubMed: 22231402
DOI: 10.1038/nsmb.2196

Experimental method

X-RAY DIFFRACTION (3.178 Å)