8FHI

Wildtype rabbit TRPV5 in nanodiscs in complex with oleoyl coenzyme A, Open stated

Summary for 8FHI

• Entry DOI: 10.2210/pdb8fhi/pdb
• EMDB information: 29086
• Descriptor: Transient receptor potential cation channel subfamily V member 5, ERGOSTEROL, S-{(3R,5R,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9Z)-octadec-9-enethioate (non-preferred name), ... (4 entities in total)
• Functional Keywords: trpv5, trp channel, oleoyl coenzyme a, open state, membrane protein
• Biological source: Oryctolagus cuniculus (rabbit)
• Total number of polymer chains: 4
• Total formula weight: 345479.75

Authors

De Jesus-Perez, J.J.,Moiseenkova-Bell, V.Y. (deposition date: 2022-12-14, release date: 2023-11-01)

• Primary citation: Lee, B.H.,De Jesus Perez, J.J.,Moiseenkova-Bell, V.,Rohacs, T.; Structural basis of the activation of TRPV5 channels by long-chain acyl-Coenzyme-A.; Nat Commun, 14:5883-5883, 2023; PubMed: 37735536; DOI: 10.1038/s41467-023-41577-z

Experimental method

ELECTRON MICROSCOPY (3.25 Å)