PDB: 593 resultsInfo pagesStatus searchChemie searchBIRD

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3UF4	Crystal structure of a SH3 and SH2 domains of FYN protein (Proto-concogene Tyrosine-protein kinase Fyn) from Mus musculus at 1.98 A resolution Descriptor: CHLORIDE ION, GLYCEROL, SODIUM ION, ... Authors: Joint Center for Structural Genomics (JCSG), Partnership for T-Cell Biology (TCELL) Deposit date: 2011-10-31 Release date: 2011-12-07 Last modified: 2023-02-01 Method: X-RAY DIFFRACTION (1.98 Å) Cite: Crystal structure of a SH3 and SH2 domains of FYN protein (Proto-concogene Tyrosine-protein kinase Fyn) from Mus musculus at 1.98 A resolution To be published
3TL0	Structure of SHP2 N-SH2 domain in complex with RLNpYAQLWHR peptide Descriptor: RLNpYAQLWHR peptide, SULFATE ION, Tyrosine-protein phosphatase non-receptor type 11 Authors: Zhang, Y, Zhang, J, Yuan, C, Hard, R.L, Park, I.H, Li, C, Bell, C.E, Pei, D. Deposit date: 2011-08-29 Release date: 2011-09-28 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Simultaneous binding of two peptidyl ligands by a SRC homology 2 domain. Biochemistry, 50, 2011
3TKZ	Structure of the SHP-2 N-SH2 domain in a 1:2 complex with RVIpYFVPLNR peptide Descriptor: PROTEIN (RVIpYFVPLNR peptide), Tyrosine-protein phosphatase non-receptor type 11 Authors: Zhang, Y, Zhang, J, Yuan, C, Hard, R.L, Park, I.H, Li, C, Bell, C.E, Pei, D. Deposit date: 2011-08-29 Release date: 2011-10-26 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Simultaneous binding of two peptidyl ligands by a SRC homology 2 domain. Biochemistry, 50, 2011
3T04	Crystal structure of monobody 7c12/abl1 sh2 domain complex Descriptor: GLYCEROL, MONOBODY 7C12, SULFATE ION, ... Authors: Wojcik, J.B, Wyrzucki, A.M, Koide, S. Deposit date: 2011-07-19 Release date: 2011-11-23 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Targeting the SH2-Kinase Interface in Bcr-Abl Inhibits Leukemogenesis. Cell(Cambridge,Mass.), 147, 2011
3S9K	Crystal structure of the Itk SH2 domain. Descriptor: CITRIC ACID, Tyrosine-protein kinase ITK/TSK Authors: Joseph, R.E, Ginder, N.D, Hoy, J.A, Nix, J.C, Fulton, B.D, Honzatko, R.B, Andreotti, A.H. Deposit date: 2011-06-01 Release date: 2012-02-08 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.354 Å) Cite: Structure of the interleukin-2 tyrosine kinase Src homology 2 domain; comparison between X-ray and NMR-derived structures. Acta Crystallogr.,Sect.F, 68, 2012
3S8O	Crystal Structure of the Grb2 SH2 Domain in Complex with a pYXN-Derived Tripeptide Descriptor: CHLORIDE ION, Growth factor receptor-bound protein 2, SODIUM ION, ... Authors: Clements, J.H, Stephen, F.M. Deposit date: 2011-05-29 Release date: 2011-11-02 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Protein-ligand interactions: thermodynamic effects associated with increasing nonpolar surface area. J.Am.Chem.Soc., 133, 2011
3S8N	Crystal Structure of the Grb2 SH2 Domain in Complex with a pYXN-Derived Tripeptide Descriptor: CHLORIDE ION, GLYCEROL, Growth factor receptor-bound protein 2, ... Authors: Clements, J.H, Stephen, F.M. Deposit date: 2011-05-29 Release date: 2011-11-02 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.71 Å) Cite: Protein-ligand interactions: thermodynamic effects associated with increasing nonpolar surface area. J.Am.Chem.Soc., 133, 2011
3S8L	Protein-Ligand Interactions: Thermodynamic Effects Associated with Increasing Hydrophobic Surface Area Descriptor: CHLORIDE ION, GLYCEROL, Growth factor receptor-bound protein 2, ... Authors: Clements, J.H, Stephen, F.M. Deposit date: 2011-05-29 Release date: 2011-11-02 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.71 Å) Cite: Protein-ligand interactions: thermodynamic effects associated with increasing nonpolar surface area. J.Am.Chem.Soc., 133, 2011
3QWY	CED-2 Descriptor: Cell death abnormality protein 2, GLYCEROL, SULFATE ION Authors: Kang, Y, Sun, J, Liu, Y, Sun, D, Hu, Y, Liu, Y.F. Deposit date: 2011-02-28 Release date: 2011-06-08 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.52 Å) Cite: Crystal structure of the cell corpse engulfment protein CED-2 in Caenorhabditis elegans. Biochem.Biophys.Res.Commun., 410, 2011
3QWX	CED-2 1-174 Descriptor: Cell death abnormality protein 2, SULFATE ION Authors: Kang, Y, Sun, J, Liu, Y. Deposit date: 2011-02-28 Release date: 2011-06-08 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.01 Å) Cite: Crystal structure of the cell corpse engulfment protein CED-2 in Caenorhabditis elegans. Biochem.Biophys.Res.Commun., 410, 2011
3PSK	Crystal Structure of the Spt6 Tandem SH2 Domain from Saccharomyces cerevisiae, Form Native Spt6 (1247-1451) Descriptor: SULFATE ION, Transcription elongation factor SPT6 Authors: Close, D, Hill, C.P. Deposit date: 2010-12-01 Release date: 2011-03-30 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal structures of the S. cerevisiae Spt6 core and C-terminal tandem SH2 domain. J.Mol.Biol., 408, 2011
3PSJ	Crystal Structure of the Spt6 Tandem SH2 Domain from Saccharomyces cerevisiae, Form Se-Spt6 (1247-1451) Descriptor: SULFATE ION, Transcription elongation factor SPT6 Authors: Close, D, Hill, C.P. Deposit date: 2010-12-01 Release date: 2011-03-30 Last modified: 2017-11-08 Method: X-RAY DIFFRACTION (2.702 Å) Cite: Crystal structures of the S. cerevisiae Spt6 core and C-terminal tandem SH2 domain. J.Mol.Biol., 408, 2011
3PSI	Crystal Structure of the Spt6 core domain from Saccharomyces cerevisiae, Form Spt6(239-1451) Descriptor: Transcription elongation factor SPT6 Authors: Close, D, Hill, C.P, Johnson, S.J. Deposit date: 2010-12-01 Release date: 2011-03-30 Last modified: 2011-08-03 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Crystal structures of the S. cerevisiae Spt6 core and C-terminal tandem SH2 domain. J.Mol.Biol., 408, 2011
3PS5	Crystal structure of the full-length Human Protein Tyrosine Phosphatase SHP-1 Descriptor: SULFATE ION, Tyrosine-protein phosphatase non-receptor type 6 Authors: Wang, W, Liu, L, Song, X, Mo, Y, Komma, C, Bellamy, H.D, Zhao, Z.J, Zhou, G.W. Deposit date: 2010-11-30 Release date: 2011-04-20 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Crystal structure of human protein tyrosine phosphatase SHP-1 in the open conformation. J.Cell.Biochem., 112, 2011
3PQZ	Grb7 SH2 with peptide Descriptor: Growth factor receptor-bound protein 7, cyclic peptide Authors: Wilce, J.A. Deposit date: 2010-11-29 Release date: 2011-07-20 Last modified: 2011-09-21 Method: X-RAY DIFFRACTION (2.413 Å) Cite: Structural basis of binding by cyclic nonphosphorylated Peptide antagonists of grb7 implicated in breast cancer progression J.Mol.Biol., 412, 2011
3OVE	Crystal Structure of the Grb2 SH2 Domain in Complex with a pYXN-Derived Tripeptide Descriptor: CHLORIDE ION, Growth factor receptor-bound protein 2, PYAC7CN Authors: Clements, J.H, Martin, S.F. Deposit date: 2010-09-16 Release date: 2011-11-02 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Protein-ligand interactions: thermodynamic effects associated with increasing nonpolar surface area. J.Am.Chem.Soc., 133, 2011
3OV1	Crystal Structure of the Grb2 SH2 Domain in Complex with a pYXN-Derived Tripeptide Descriptor: FORMIC ACID, GLYCEROL, Growth factor receptor-bound protein 2, ... Authors: Clements, J.H, Martin, S.F. Deposit date: 2010-09-15 Release date: 2011-11-02 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Protein-ligand interactions: thermodynamic effects associated with increasing nonpolar surface area. J.Am.Chem.Soc., 133, 2011
3NHN	Crystal structure of the SRC-family kinase HCK SH3-SH2-linker regulatory region Descriptor: Tyrosine-protein kinase HCK Authors: Alvarado, J.J, Betts, L, Moroco, J.A, Smithgall, T.E, Yeh, J.I. Deposit date: 2010-06-14 Release date: 2010-09-01 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.61 Å) Cite: Crystal Structure of the Src Family Kinase Hck SH3-SH2 Linker Regulatory Region Supports an SH3-dominant Activation Mechanism. J.Biol.Chem., 285, 2010
3N8M	Crystal Structure of the Grb2 SH2 Domain in Complex with An Acyclic Ligand Having the Sequence pYVNVP Descriptor: GLYCEROL, Growth factor receptor-bound protein 2, PEPTIDE Authors: Whiddon, B.B, Clements, J.H, Martin, S.F. Deposit date: 2010-05-28 Release date: 2010-12-15 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2 Å) Cite: Thermodynamic and Structural Effects of Macrocyclization as a Constraining Method in Protein-Ligand Interactions. ACS MED.CHEM.LETT., 1, 2010
3N84	Crystal Structure of the Grb2 SH2 Domain in Complex with a 23-Membered Macrocyclic Ligand Having the Sequence pYVNVP Descriptor: 23-membered peptide-like macrocyclic ligand, CHLORIDE ION, GLYCEROL, ... Authors: Clements, J.H, Martin, S.F. Deposit date: 2010-05-27 Release date: 2011-01-12 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2 Å) Cite: Thermodynamic and Structural Effects of Macrocyclization as a Constraining Method in Protein-Ligand Interactions. ACS MED.CHEM.LETT., 1, 2010
3N7Y	Crystal Structure of the Grb2 SH2 Domain in Complex with a 20-Membered Macrocyclic Ligand Having the Sequence pYVNV Descriptor: 20-membered peptide-like macrocyclic ligand, Growth factor receptor-bound protein 2 Authors: Whiddon, B.B, Clements, J.H, Martin, S.F. Deposit date: 2010-05-27 Release date: 2011-01-12 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.02 Å) Cite: Thermodynamic and Structural Effects of Macrocyclization as a Constraining Method in Protein-Ligand Interactions. ACS MED.CHEM.LETT., 1, 2010
3MXY	Structures of Grb2-SH2 Domain and AICD peptide Complexes Reveal a Conformational Switch and Their Functional Implications. Descriptor: AICD peptide E683V variant, Growth factor receptor-bound protein 2 Authors: Sen, U, Das, S. Deposit date: 2010-05-08 Release date: 2011-05-11 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Functional Implications of the Conformational Switch in AICD Peptide upon Binding to Grb2-SH2 Domain. J.Mol.Biol., 414, 2011
3MXC	Structures of Grb2-SH2 Domain and AICD peptide Complexes Reveal a Conformational Switch and Their Functional Implications. Descriptor: AICD peptide, Growth factor receptor-bound protein 2 Authors: Sen, U, Das, S. Deposit date: 2010-05-07 Release date: 2011-05-11 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2 Å) Cite: Functional Implications of the Conformational Switch in AICD Peptide upon Binding to Grb2-SH2 Domain. J.Mol.Biol., 414, 2011
3MAZ	Crystal Structure of the Human BRDG1/STAP-1 SH2 Domain in Complex with the NTAL pTyr136 Peptide Descriptor: CheD family protein, MALONATE ION, Signal-transducing adaptor protein 1 Authors: Kaneko, T, Huang, H, Zhao, B, Li, L, Liu, H, Voss, C.K, Wu, C, Schiller, M.R, Li, S.S. Deposit date: 2010-03-24 Release date: 2010-05-12 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Loops govern SH2 domain specificity by controlling access to binding pockets. Sci.Signal., 3, 2010
3M7F	Crystal structure of the Nedd4 C2/Grb10 SH2 complex Descriptor: E3 ubiquitin-protein ligase NEDD4, Growth factor receptor-bound protein 10 Authors: Huang, Q, Szebenyi, M. Deposit date: 2010-03-16 Release date: 2010-10-27 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural Basis for the Interaction between the Growth Factor-binding Protein GRB10 and the E3 Ubiquitin Ligase NEDD4. J.Biol.Chem., 285, 2010

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