PDB: 593 件ウェブページステータス検索Chemie searchBIRD

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3PS5	Crystal structure of the full-length Human Protein Tyrosine Phosphatase SHP-1 分子名称: SULFATE ION, Tyrosine-protein phosphatase non-receptor type 6 著者 Wang, W, Liu, L, Song, X, Mo, Y, Komma, C, Bellamy, H.D, Zhao, Z.J, Zhou, G.W. 登録日 2010-11-30 公開日 2011-04-20 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Crystal structure of human protein tyrosine phosphatase SHP-1 in the open conformation. J.Cell.Biochem., 112, 2011
4OHI	LEOPARD Syndrome-Associated SHP2/Q510E mutant 分子名称: Tyrosine-protein phosphatase non-receptor type 11 著者 Yu, Z.H, Zhang, R.Y, Walls, C.D, Chen, L, Zhang, S, Wu, L, Wang, L, Liu, S, Zhang, Z.Y. 登録日 2014-01-17 公開日 2014-09-24 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Molecular basis of gain-of-function LEOPARD syndrome-associated SHP2 mutations. Biochemistry, 53, 2014
4OHH	LEOPARD Syndrome-Associated SHP2/Q506P mutant 分子名称: Tyrosine-protein phosphatase non-receptor type 11 著者 Yu, Z.H, Zhang, R.Y, Walls, C.D, Chen, L, Zhang, S, Wu, L, Wang, L, Liu, S, Zhang, Z.Y. 登録日 2014-01-17 公開日 2014-09-24 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Molecular basis of gain-of-function LEOPARD syndrome-associated SHP2 mutations. Biochemistry, 53, 2014
4OHL	LEOPARD Syndrome-Associated SHP2/T468M mutant 分子名称: Tyrosine-protein phosphatase non-receptor type 11 著者 Yu, Z.H, Zhang, R.Y, Walls, C.D, Chen, L, Zhang, S, Wu, L, Wang, L, Liu, S, Zhang, Z.Y. 登録日 2014-01-17 公開日 2014-09-24 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Molecular basis of gain-of-function LEOPARD syndrome-associated SHP2 mutations. Biochemistry, 53, 2014
3QWY	CED-2 分子名称: Cell death abnormality protein 2, GLYCEROL, SULFATE ION 著者 Kang, Y, Sun, J, Liu, Y, Sun, D, Hu, Y, Liu, Y.F. 登録日 2011-02-28 公開日 2011-06-08 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.52 Å) 主引用文献 Crystal structure of the cell corpse engulfment protein CED-2 in Caenorhabditis elegans. Biochem.Biophys.Res.Commun., 410, 2011
3QWX	CED-2 1-174 分子名称: Cell death abnormality protein 2, SULFATE ION 著者 Kang, Y, Sun, J, Liu, Y. 登録日 2011-02-28 公開日 2011-06-08 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Crystal structure of the cell corpse engulfment protein CED-2 in Caenorhabditis elegans. Biochem.Biophys.Res.Commun., 410, 2011
6ATD	Oxidized SHP2 forms a disulfide bond between Cys367 and Cys459 分子名称: PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 11 著者 Page, R, Peti, W, Critton, D.A. 登録日 2017-08-28 公開日 2018-07-11 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Redox Regulation of a Gain-of-Function Mutation (N308D) in SHP2 Noonan Syndrome. ACS Omega, 2, 2017
6AMW	Abl1b Regulatory Module 'Activating' conformation 分子名称: Tyrosine-protein kinase ABL1 著者 Kalodimos, C.G, Rossi, P, Saleh, T. 登録日 2017-08-11 公開日 2017-09-27 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Atomic view of the energy landscape in the allosteric regulation of Abl kinase. Nat. Struct. Mol. Biol., 24, 2017
6AMV	Abl 1b Regulatory Module 'inhibiting state' 分子名称: Tyrosine-protein kinase ABL1 著者 Kalodimos, C.G, Saleh, T, Rossi, P. 登録日 2017-08-11 公開日 2017-09-27 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Atomic view of the energy landscape in the allosteric regulation of Abl kinase. Nat. Struct. Mol. Biol., 24, 2017
6BMV	Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor SHP504 分子名称: 3-{4-[(2-chlorophenyl)methyl]-5-oxo-4,5-dihydro[1,2,4]triazolo[4,3-a]quinazolin-1-yl}-4-hydroxybenzoic acid, PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 11 著者 Stams, T, Fodor, M. 登録日 2017-11-15 公開日 2018-01-17 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.053 Å) 主引用文献 Dual Allosteric Inhibition of SHP2 Phosphatase. ACS Chem. Biol., 13, 2018
6BMU	Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitors SHP099 and SHP244 分子名称: 4-[(2-chlorophenyl)methyl]-1-(2-hydroxy-3-methoxyphenyl)[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one, 6-(4-azanyl-4-methyl-piperidin-1-yl)-3-[2,3-bis(chloranyl)phenyl]pyrazin-2-amine, GLYCEROL, ... 著者 Stams, T, Fodor, M. 登録日 2017-11-15 公開日 2018-01-17 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.12 Å) 主引用文献 Dual Allosteric Inhibition of SHP2 Phosphatase. ACS Chem. Biol., 13, 2018
6BN5	Non-receptor Protein Tyrosine Phosphatase SHP2 F285S in Complex with Allosteric Inhibitor JLR-2 分子名称: 3-benzyl-8-chloro-2-hydroxy-4H-pyrimido[2,1-b][1,3]benzothiazol-4-one, Tyrosine-protein phosphatase non-receptor type 11 著者 Blacklow, S.C, Stams, T, Fodor, M, LaRochelle, J.R. 登録日 2017-11-16 公開日 2017-12-13 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.22 Å) 主引用文献 Identification of an allosteric benzothiazolopyrimidone inhibitor of the oncogenic protein tyrosine phosphatase SHP2. Bioorg. Med. Chem., 25, 2017
6BMR	Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor SHP244 分子名称: 4-[(2-chlorophenyl)methyl]-1-(2-hydroxy-3-methoxyphenyl)[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one, GLYCEROL, PHOSPHATE ION, ... 著者 Stams, T, Fodor, M. 登録日 2017-11-15 公開日 2018-01-17 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.205 Å) 主引用文献 Dual Allosteric Inhibition of SHP2 Phosphatase. ACS Chem. Biol., 13, 2018
6BMY	Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitors SHP099 and SHP844 分子名称: 1-(3-chloro-4-{[1-(2-hydroxy-3-methoxyphenyl)-5-oxo[1,2,4]triazolo[4,3-a]quinazolin-4(5H)-yl]methyl}benzene-1-carbonyl)-L-proline, 6-(4-azanyl-4-methyl-piperidin-1-yl)-3-[2,3-bis(chloranyl)phenyl]pyrazin-2-amine, GLYCEROL, ... 著者 Stams, T, Fodor, M. 登録日 2017-11-15 公開日 2018-01-17 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 Dual Allosteric Inhibition of SHP2 Phosphatase. ACS Chem. Biol., 13, 2018
6BMX	Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor SHP844 分子名称: 1-(3-chloro-4-{[1-(2-hydroxy-3-methoxyphenyl)-5-oxo[1,2,4]triazolo[4,3-a]quinazolin-4(5H)-yl]methyl}benzene-1-carbonyl)-L-proline, GLYCEROL, PHOSPHATE ION, ... 著者 Stams, T, Fodor, M. 登録日 2017-11-15 公開日 2018-01-17 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.424 Å) 主引用文献 Dual Allosteric Inhibition of SHP2 Phosphatase. ACS Chem. Biol., 13, 2018
6BMW	Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitors SHP099 and SHP504 分子名称: 3-{4-[(2-chlorophenyl)methyl]-5-oxo-4,5-dihydro[1,2,4]triazolo[4,3-a]quinazolin-1-yl}-4-hydroxybenzoic acid, 6-(4-azanyl-4-methyl-piperidin-1-yl)-3-[2,3-bis(chloranyl)phenyl]pyrazin-2-amine, GLYCEROL, ... 著者 Stams, T, Fodor, M. 登録日 2017-11-15 公開日 2018-01-17 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Dual Allosteric Inhibition of SHP2 Phosphatase. ACS Chem. Biol., 13, 2018
1FMK	CRYSTAL STRUCTURE OF HUMAN TYROSINE-PROTEIN KINASE C-SRC 分子名称: TYROSINE-PROTEIN KINASE SRC 著者 Xu, W, Harrison, S.C, Eck, M.J. 登録日 1997-01-24 公開日 1997-08-20 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Three-dimensional structure of the tyrosine kinase c-Src. Nature, 385, 1997
4D8K	Crystal structure of a SH3-SH2 domains of a lymphocyte-specific protein tyrosine kinase (LCK) from Homo sapiens at 2.36 A resolution 分子名称: GLYCEROL, SULFATE ION, Tyrosine-protein kinase Lck 著者 Joint Center for Structural Genomics (JCSG), Partnership for T-Cell Biology (TCELL) 登録日 2012-01-10 公開日 2012-01-25 最終更新日 2023-02-01 実験手法 X-RAY DIFFRACTION (2.36 Å) 主引用文献 Crystal structure of a SH3-SH2 domains of a lymphocyte-specific protein tyrosine kinase (LCK) from Homo sapiens at 2.36 A resolution To be published
1G83	CRYSTAL STRUCTURE OF FYN SH3-SH2 分子名称: PROTO-ONCOGENE TYROSINE-PROTEIN KINASE FYN 著者 Arold, S.T, Ulmer, T.S, Mulhern, T.D, Werner, J.M, Ladbury, J.E, Campbell, I.D, Noble, M.E.M. 登録日 2000-11-16 公開日 2001-05-30 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 The role of the Src homology 3-Src homology 2 interface in the regulation of Src kinases. J.Biol.Chem., 276, 2001
4DGP	The wild-type Src homology 2 (SH2)-domain containing protein tyrosine phosphatase-2 (SHP2) 分子名称: Tyrosine-protein phosphatase non-receptor type 11 著者 Yu, Z.H, Xu, J, Walls, C.D, Chen, L, Zhang, S, Wu, L, Wang, L.N, Liu, S.J, Zhang, Z.Y. 登録日 2012-01-26 公開日 2013-03-06 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural and Mechanistic Insights into LEOPARD Syndrome-Associated SHP2 Mutations. J.Biol.Chem., 288, 2013
1GRI	GRB2 分子名称: GROWTH FACTOR BOUND PROTEIN 2 著者 Maignan, S, Arnoux, B, Ducruix, A. 登録日 1995-02-28 公開日 1996-03-08 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Crystal structure of the mammalian Grb2 adaptor. Science, 268, 1995
4DGX	LEOPARD Syndrome-Associated SHP2/Y279C mutant 分子名称: Tyrosine-protein phosphatase non-receptor type 11 著者 Yu, Z.H, Xu, J, Walls, C.D, Chen, L, Zhang, S, Wu, L, Wang, L.N, Liu, S.J, Zhang, Z.Y. 登録日 2012-01-27 公開日 2013-03-06 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural and Mechanistic Insights into LEOPARD Syndrome-Associated SHP2 Mutations. J.Biol.Chem., 288, 2013
4E68	Unphosphorylated STAT3B core protein binding to dsDNA 分子名称: DNA (5'-D(*TP*GP*CP*AP*TP*TP*TP*CP*CP*CP*GP*TP*AP*AP*AP*TP*CP*T)-3'), Signal transducer and activator of transcription 3 著者 Collie, G.W, Parkinson, G.N, Shah, R. 登録日 2012-03-15 公開日 2013-03-06 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.585 Å) 主引用文献 Observation of unphosphorylated STAT3 core protein binding to target dsDNA by PEMSA and X-ray crystallography. Febs Lett., 587, 2013
4E93	Crystal structure of human Feline Sarcoma Viral Oncogene Homologue (v-FES)in complex with TAE684 分子名称: 5-CHLORO-N-[2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL)PIPERIDIN-1-YL]PHENYL]-N'-(2-PROPAN-2-YLSULFONYLPHENYL)PYRIMIDINE-2,4-DIAMINE, Tyrosine-protein kinase Fes/Fps 著者 Filippakopoulos, P, Salah, E, Miduturu, C.V, Fedorov, O, Cooper, C, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Gray, N.S, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2012-03-20 公開日 2012-04-18 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 Small-Molecule Inhibitors of the c-Fes Protein-Tyrosine Kinase. Chem.Biol., 19, 2012
4FL3	Structural and Biophysical Characterization of the Syk Activation Switch 分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Tyrosine-protein kinase SYK 著者 Graedler, U, Schwarz, D, Dresing, V, Musil, M, Bomke, J, Frech, M, Jaekel, S, Rysiok, T, Mueller-Pompalla, D, Wegener, A. 登録日 2012-06-14 公開日 2012-11-28 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural and biophysical characterization of the syk activation switch. J.Mol.Biol., 425, 2013

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