6ATD

Oxidized SHP2 forms a disulfide bond between Cys367 and Cys459

Summary for 6ATD

Entry DOI	10.2210/pdb6atd/pdb
Descriptor	Tyrosine-protein phosphatase non-receptor type 11, PHOSPHATE ION (3 entities in total)
Functional Keywords	hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	121524.41
Authors	Page, R.,Peti, W.,Critton, D.A. (deposition date: 2017-08-28, release date: 2018-07-11, Last modification date: 2023-10-04)
Primary citation	Machado, L.E.S.F.,Critton, D.A.,Page, R.,Peti, W. Redox Regulation of a Gain-of-Function Mutation (N308D) in SHP2 Noonan Syndrome. ACS Omega, 2:8313-8318, 2017 Cited by PubMed: 29214238 DOI: 10.1021/acsomega.7b01318 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation