6ATD
Oxidized SHP2 forms a disulfide bond between Cys367 and Cys459
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Tyrosine-protein phosphatase non-receptor type 11 | polymer | 528 | 60572.3 | 2 | UniProt (Q06124) Pfam (PF00017) Pfam (PF00102) In PDB | Homo sapiens (Human) | Protein-tyrosine phosphatase 1D,PTP-1D,Protein-tyrosine phosphatase 2C,PTP-2C,SH-PTP2,Shp2,SH-PTP3 |
| 2 | A, B | PHOSPHATE ION | non-polymer | 95.0 | 4 | Chemie (PO4) | |||
| 3 | water | water | 18.0 | 180 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 526 (UniProt: Q06124)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| His 0 | - | expression tag |
| Asp 308 | Asn 308 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 121144.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 379.9 | |
| All* | Total formula weight | 121524.4 |
