5XX8
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5XX7
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5XX6
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5XX5
| A BPTI-[5,55] variant with C14GA38I mutations | Descriptor: | Pancreatic trypsin inhibitor, SULFATE ION | Authors: | Islam, M.M. | Deposit date: | 2017-07-01 | Release date: | 2018-07-04 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.38 Å) | Cite: | Hydrophobic surface residues can stabilize a protein through improved water-protein interactions. Febs J., 2019
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5XX4
| A BPTI-[5,55] variant with C14GA38K mutations | Descriptor: | Pancreatic trypsin inhibitor, SULFATE ION | Authors: | Islam, M.M. | Deposit date: | 2017-07-01 | Release date: | 2018-07-04 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | Hydrophobic surface residues can stabilize a protein through improved water-protein interactions. Febs J., 2019
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5XX3
| A BPTI-[5,55] variant with C14GA38G mutations | Descriptor: | Pancreatic trypsin inhibitor, SULFATE ION | Authors: | Islam, M.M. | Deposit date: | 2017-07-01 | Release date: | 2018-07-04 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.12 Å) | Cite: | Hydrophobic surface residues can stabilize a protein through improved water-protein interactions. Febs J., 2019
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5XX2
| A BPTI-[5,55] variant with C14GA38L mutations | Descriptor: | Pancreatic trypsin inhibitor, SULFATE ION | Authors: | Islam, M.M. | Deposit date: | 2017-07-01 | Release date: | 2018-07-04 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.12 Å) | Cite: | Hydrophobic surface residues can stabilize a protein through improved water-protein interactions. Febs J., 2019
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5PTI
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5NX3
| Combinatorial Engineering of Proteolytically Resistant APPI Variants that Selectively Inhibit Human Kallikrein 6 for Cancer Therapy | Descriptor: | Amyloid-beta A4 protein, Kallikrein-6 | Authors: | Shahar, A, Sananes, A, Radisky, E.S, Papo, N. | Deposit date: | 2017-05-09 | Release date: | 2018-05-30 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.296 Å) | Cite: | A potent, proteolysis-resistant inhibitor of kallikrein-related peptidase 6 (KLK6) for cancer therapy, developed by combinatorial engineering. J.Biol.Chem., 293, 2018
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5NX1
| Combinatorial Engineering of Proteolytically Resistant APPI Variants that Selectively Inhibit Human Kallikrein 6 for Cancer Therapy | Descriptor: | Amyloid-beta A4 protein, Kallikrein-6 | Authors: | Shahar, A, Sananes, A, Radisky, E.S, Papo, N. | Deposit date: | 2017-05-09 | Release date: | 2018-05-30 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.853 Å) | Cite: | A potent, proteolysis-resistant inhibitor of kallikrein-related peptidase 6 (KLK6) for cancer therapy, developed by combinatorial engineering. J.Biol.Chem., 293, 2018
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5NMV
| Crystal structure of 2F22 Fab fragment against TFPI1 | Descriptor: | Fab heavy chain, Fab light chain, GLYCEROL, ... | Authors: | Svensson, L.A, Petersen, H.H. | Deposit date: | 2017-04-07 | Release date: | 2018-03-28 | Last modified: | 2018-05-09 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Factor Xa and VIIa inhibition by tissue factor pathway inhibitor is prevented by a monoclonal antibody to its Kunitz-1 domain. J. Thromb. Haemost., 16, 2018
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5M4V
| X-ray structure of the mambaquaretin-1, a selective antagonist of the vasopressin type 2 receptor | Descriptor: | CHLORIDE ION, Mambaquaretin-1, S-1,2-PROPANEDIOL | Authors: | Stura, E.A, Vera, L, Ciolek, J, Mourier, G, Gilles, N. | Deposit date: | 2016-10-19 | Release date: | 2017-05-03 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.06 Å) | Cite: | Green mamba peptide targets type-2 vasopressin receptor against polycystic kidney disease. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5JBT
| Mesotrypsin in complex with cleaved amyloid precursor like protein 2 inhibitor (APLP2) | Descriptor: | Amyloid-like protein 2, CALCIUM ION, PRSS3 protein, ... | Authors: | Kayode, O, Wang, R, Pendlebury, D, Soares, A, Radisky, E.S. | Deposit date: | 2016-04-13 | Release date: | 2016-11-09 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | An Acrobatic Substrate Metamorphosis Reveals a Requirement for Substrate Conformational Dynamics in Trypsin Proteolysis. J. Biol. Chem., 291, 2016
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5JB7
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5JB6
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5JB5
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5JB4
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5H7V
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5EZD
| Crystal structure of a Hepatocyte growth factor activator inhibitor-1 (HAI-1) fragment covering the PKD-like 'internal' domain and Kunitz domain 1 | Descriptor: | ACETATE ION, Kunitz-type protease inhibitor 1, POTASSIUM ION | Authors: | Hong, Z, Andreasen, P.A, Morth, J.P, Jensen, J.K. | Deposit date: | 2015-11-26 | Release date: | 2016-05-18 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal Structure of a Two-domain Fragment of Hepatocyte Growth Factor Activator Inhibitor-1: FUNCTIONAL INTERACTIONS BETWEEN THE KUNITZ-TYPE INHIBITOR DOMAIN-1 AND THE NEIGHBORING POLYCYSTIC KIDNEY DISEASE-LIKE DOMAIN. J.Biol.Chem., 291, 2016
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5C67
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4Y11
| Trypsin in complex with with BPTI mutant (2S)-2-amino-4,4,4-trifluorobutanoic acid | Descriptor: | CALCIUM ION, Cationic trypsin, GLYCEROL, ... | Authors: | Loll, B, Ye, S, Berger, A.A, Muelow, U, Alings, C, Wahl, M.C, Koksch, B. | Deposit date: | 2015-02-06 | Release date: | 2015-06-24 | Last modified: | 2018-04-18 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Fluorine teams up with water to restore inhibitor activity to mutant BPTI. Chem Sci, 6, 2015
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4Y10
| Trypsin in complex with with BPTI mutant (2S)-2-amino-4,4-difluorobutanoic acid | Descriptor: | CALCIUM ION, Cationic trypsin, GLYCEROL, ... | Authors: | Loll, B, Ye, S, Berger, A.A, Muelow, U, Alings, C, Wahl, M.C, Koksch, B. | Deposit date: | 2015-02-06 | Release date: | 2015-06-24 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.37 Å) | Cite: | Fluorine teams up with water to restore inhibitor activity to mutant BPTI. Chem Sci, 6, 2015
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4Y0Z
| Trypsin in complex with with BPTI mutant AMINOBUTYRIC ACID | Descriptor: | CALCIUM ION, Cationic trypsin, GLYCEROL, ... | Authors: | Loll, B, Ye, S, Berger, A.A, Muelow, U, Alings, C, Wahl, M.C, Koksch, B. | Deposit date: | 2015-02-06 | Release date: | 2015-06-24 | Last modified: | 2018-04-18 | Method: | X-RAY DIFFRACTION (1.37 Å) | Cite: | Fluorine teams up with water to restore inhibitor activity to mutant BPTI. Chem Sci, 6, 2015
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4Y0Y
| Trypsin in complex with with BPTI | Descriptor: | CALCIUM ION, Cationic trypsin, GLYCEROL, ... | Authors: | Loll, B, Ye, S, Berger, A.A, Muelow, U, Alings, C, Wahl, M.C, Koksch, B. | Deposit date: | 2015-02-06 | Release date: | 2015-06-24 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Fluorine teams up with water to restore inhibitor activity to mutant BPTI. Chem Sci, 6, 2015
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4WXV
| Human cationic trypsin K97D mutant in complex with bovine pancreatic trypsin inhibitor (BPTI) | Descriptor: | CALCIUM ION, Pancreatic trypsin inhibitor, SULFATE ION, ... | Authors: | Alloy, A, Kayode, O, Soares, A.S, Wang, R, Radisky, E.S. | Deposit date: | 2014-11-14 | Release date: | 2015-07-22 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Mesotrypsin Has Evolved Four Unique Residues to Cleave Trypsin Inhibitors as Substrates. J.Biol.Chem., 290, 2015
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