PDB: 1182 件ウェブページステータス検索Chemie searchBIRD

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7NA8	Structures of human ghrelin receptor-Gi complexes with ghrelin and a synthetic agonist 分子名称: 1-(methanesulfonyl)-1'-(2-methyl-L-alanyl-O-benzyl-D-seryl)-1,2-dihydrospiro[indole-3,4'-piperidine], Antibody fragment, CHOLESTEROL, ... 著者 Liu, H, Sun, D, Sun, J, Zhang, C. 登録日 2021-06-20 公開日 2021-12-15 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Structural basis of human ghrelin receptor signaling by ghrelin and the synthetic agonist ibutamoren Nat Commun, 12, 2021
7F55	Cryo-EM structure of bremelanotide-MC4R-Gs_Nb35 complex 分子名称: CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Zhang, H, Chen, L, Mao, C, Shen, Q, Yang, D, Shen, D, Qin, J. 登録日 2021-06-21 公開日 2021-11-03 最終更新日 2022-02-16 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural insights into ligand recognition and activation of the melanocortin-4 receptor. Cell Res., 31, 2021
7F54	Cryo-EM structure of afamelanotide-MC4R-Gs_Nb35 complex 分子名称: CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Zhang, H, Chen, L, Mao, C, Shen, Q, Yang, D, Shen, D, Qin, J. 登録日 2021-06-21 公開日 2021-11-03 最終更新日 2022-02-16 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural insights into ligand recognition and activation of the melanocortin-4 receptor. Cell Res., 31, 2021
7F58	Cryo-EM structure of THIQ-MC4R-Gs_Nb35 complex 分子名称: (3R)-N-[(2R)-3-(4-chlorophenyl)-1-[4-cyclohexyl-4-(1,2,4-triazol-1-ylmethyl)piperidin-1-yl]-1-oxidanylidene-propan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Zhang, H, Chen, L, Mao, C, Shen, Q, Yang, D, Shen, D, Qin, J. 登録日 2021-06-21 公開日 2021-11-03 最終更新日 2022-02-16 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural insights into ligand recognition and activation of the melanocortin-4 receptor. Cell Res., 31, 2021
7F53	Cryo-EM structure of a-MSH-MC4R-Gs_Nb35 complex 分子名称: CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Zhang, H, Chen, L, Mao, C, Shen, Q, Yang, D, Shen, D, Qin, J. 登録日 2021-06-21 公開日 2021-11-03 最終更新日 2022-02-16 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural insights into ligand recognition and activation of the melanocortin-4 receptor. Cell Res., 31, 2021
7F61	Crystal structure of human histamine receptor H3R in complex with antagonist PF03654746 分子名称: CHOLESTEROL, Histamine H3 receptor, N-ethyl-3-fluoranyl-3-[3-fluoranyl-4-(pyrrolidin-1-ylmethyl)phenyl]cyclobutane-1-carboxamide, ... 著者 Peng, X, Zhang, H. 登録日 2021-06-23 公開日 2022-10-26 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural basis for recognition of antihistamine drug by human histamine receptor. Nat Commun, 13, 2022
7F6H	Cryo-EM structure of human bradykinin receptor BK2R in complex Gq proteins and bradykinin 分子名称: Bradykinin, Bradykinin receptor BK2R, CHOLESTEROL, ... 著者 Shen, J, Zhang, D, Fu, Y, Chen, A, Zhang, H. 登録日 2021-06-25 公開日 2022-01-05 最終更新日 2023-01-18 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Cryo-EM structures of human bradykinin receptor-G q proteins complexes. Nat Commun, 13, 2022
7F6I	Cryo-EM structure of human bradykinin receptor BK2R in complex Gq proteins and kallidin 分子名称: Bradykinin receptor BK2R, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Shen, J, Zhang, D, Fu, Y, Chen, A, Zhang, H. 登録日 2021-06-25 公開日 2022-01-05 最終更新日 2023-01-18 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Cryo-EM structures of human bradykinin receptor-G q proteins complexes. Nat Commun, 13, 2022
7P02	Human Neurokinin 1 receptor (NK1R) substance P Gs complex 分子名称: Antibody fragment scFv16, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Thom, C, Ehrenmann, J, Vacca, S, Waltenspuhl, Y, Schoppe, J, Medalia, O, Pluckthun, A. 登録日 2021-06-29 公開日 2021-12-15 実験手法 ELECTRON MICROSCOPY (2.87 Å) 主引用文献 Structures of neurokinin 1 receptor in complex with G q and G s proteins reveal substance P binding mode and unique activation features. Sci Adv, 7, 2021
7P00	Human Neurokinin 1 receptor (NK1R) substance P Gq chimera (mGsqi) complex 分子名称: Antibody fragment scFv16, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Thom, C, Ehrenmann, J, Vacca, S, Waltenspuhl, Y, Schoppe, J, Medalia, O, Pluckthun, A. 登録日 2021-06-29 公開日 2021-12-15 実験手法 ELECTRON MICROSCOPY (2.71 Å) 主引用文献 Structures of neurokinin 1 receptor in complex with G q and G s proteins reveal substance P binding mode and unique activation features. Sci Adv, 7, 2021
7F83	Crystal Structure of a receptor in Complex with inverse agonist 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-(2-methylimidazo[2,1-b][1,3]thiazol-6-yl)-1-[2-[(1R)-5-(6-methylpyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]nonan-7-yl]ethanone, Growth hormone secretagogue receptor type 1,Soluble cytochrome b562 著者 Xu, Z, Shao, Z. 登録日 2021-07-01 公開日 2022-01-19 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.94 Å) 主引用文献 Molecular mechanism of agonism and inverse agonism in ghrelin receptor. Nat Commun, 13, 2022
7RAN	5-HT2AR bound to a novel agonist in complex with a mini-Gq protein and an active-state stabilizing single-chain variable fragment (scFv16) obtained by cryo-electron microscopy (cryoEM) 分子名称: (3R)-3-methyl-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,2,3,6-tetrahydropyridin-1-ium, 5-hydroxytryptamine receptor 2A, G protein subunit q (Gi2-mini-Gq chimera), ... 著者 Barros-Alvarez, X, Kim, K, Panova, O, Roth, B.L, Skiniotis, G. 登録日 2021-07-02 公開日 2022-07-06 最終更新日 2022-11-02 実験手法 ELECTRON MICROSCOPY (3.45 Å) 主引用文献 Bespoke library docking for 5-HT 2A receptor agonists with antidepressant activity. Nature, 610, 2022
7F8V	Cryo-EM structure of the cholecystokinin receptor CCKBR in complex with gastrin-17 and Gi 分子名称: Gastrin-17, Gastrin/cholecystokinin type B receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Zhang, X, He, C, Wang, M, Zhou, Q, Yang, D, Zhu, Y, Wu, B, Zhao, Q. 登録日 2021-07-02 公開日 2021-10-13 最終更新日 2022-02-16 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structures of the human cholecystokinin receptors bound to agonists and antagonists. Nat.Chem.Biol., 17, 2021
7F8Y	Crystal structure of the cholecystokinin receptor CCKAR in complex with devazepide 分子名称: N-[(3S)-1-methyl-2-oxidanylidene-5-phenyl-3H-1,4-benzodiazepin-3-yl]-1H-indole-2-carboxamide, fusion protein of Cholecystokinin receptor type A and Endolysin 著者 Zhang, X, He, C, Wang, M, Zhou, Q, Yang, D, Zhu, Y, Wu, B, Zhao, Q. 登録日 2021-07-02 公開日 2021-10-13 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structures of the human cholecystokinin receptors bound to agonists and antagonists. Nat.Chem.Biol., 17, 2021
7F8U	Crystal structure of the cholecystokinin receptor CCKAR in complex with lintitript 分子名称: 2-[2-[[4-(2-chlorophenyl)-1,3-thiazol-2-yl]carbamoyl]indol-1-yl]ethanoic acid, Fusion protein of Cholecystokinin receptor type A and Endolysin 著者 Zhang, X, He, C, Wang, M, Zhou, Q, Yang, D, Zhu, Y, Wu, B, Zhao, Q. 登録日 2021-07-02 公開日 2021-10-13 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structures of the human cholecystokinin receptors bound to agonists and antagonists. Nat.Chem.Biol., 17, 2021
7F8W	Cryo-EM structure of the cholecystokinin receptor CCKBR in complex with gastrin-17 and Gq 分子名称: Gastrin-17, Gastrin/cholecystokinin type B receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Zhang, X, He, C, Wang, M, Zhou, Q, Yang, D, Zhu, Y, Wu, B, Zhao, Q. 登録日 2021-07-02 公開日 2021-10-13 最終更新日 2022-02-16 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structures of the human cholecystokinin receptors bound to agonists and antagonists. Nat.Chem.Biol., 17, 2021
7F8X	Crystal structure of the cholecystokinin receptor CCKAR in complex with NN9056 分子名称: ASP-SMF-NLE-GLY-TRP-NLE-OEM-MEA-NH2 (NN9056), Cholecystokinin receptor type A,Endolysin 著者 Zhang, X, He, C, Wang, M, Zhou, Q, Yang, D, Zhu, Y, Wu, B, Zhao, Q. 登録日 2021-07-02 公開日 2021-12-29 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structures of the human cholecystokinin receptors bound to agonists and antagonists. Nat.Chem.Biol., 17, 2021
7F9Y	ghrelin-bound ghrelin receptor in complex with Gq 分子名称: CHOLESTEROL, Engineered G-alpha-q subunit, Ghrelin-28, ... 著者 Wang, Y, Zhuang, Y, Xu, P, Xu, H.E, Jiang, Y. 登録日 2021-07-05 公開日 2021-08-18 最終更新日 2022-03-16 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Molecular recognition of an acyl-peptide hormone and activation of ghrelin receptor. Nat Commun, 12, 2021
7F9Z	GHRP-6-bound ghrelin receptor in complex with Gq 分子名称: 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.]PYRAZOLE, Engineered G-alpha-q, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Wang, Y, Zhuang, Y, Xu, P, Xu, H.E, Jiang, Y. 登録日 2021-07-05 公開日 2021-08-18 最終更新日 2022-03-16 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Molecular recognition of an acyl-peptide hormone and activation of ghrelin receptor. Nat Commun, 12, 2021
7FEE	Crystal structure of the allosteric modulator ZCZ011 binding to CP55940-bound cannabinoid receptor 1 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-[(1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-5-(2-methyloctan-2-yl)phenol, 6-methyl-3-[(1S)-2-nitro-1-thiophen-2-yl-ethyl]-2-phenyl-1H-indole, ... 著者 Wang, X, Zhao, C, Shao, Z. 登録日 2021-07-19 公開日 2022-06-15 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Molecular mechanism of allosteric modulation for the cannabinoid receptor CB1. Nat.Chem.Biol., 18, 2022
7RKY	Binding mode of US27-Gi-scFv16 in OCL-state 分子名称: Antibody fragment scFv16, G-protein coupled receptor homolog US27, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Tsutsumi, N, Jude, K.M, Garcia, K.C. 登録日 2021-07-22 公開日 2022-01-26 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins Sci Adv, 8, 2022
7RKN	Structure of CX3CL1-US28-Gi-scFv16 in OC-state 分子名称: Antibody fragment scFv16, Fractalkine, G-protein coupled receptor homolog US28, ... 著者 Tsutsumi, N, Qu, Q, Jude, K.M, Skiniotis, G, Garcia, K.C. 登録日 2021-07-22 公開日 2022-01-26 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins Sci Adv, 8, 2022
7RKX	Structure of US27-Gi-scFv16 in CL-state 分子名称: Antibody fragment scFv16, G-protein coupled receptor homolog US27, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Tsutsumi, N, Jude, K.M, Garcia, K.C. 登録日 2021-07-22 公開日 2022-01-26 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins Sci Adv, 8, 2022
7RKF	Structure of CX3CL1-US28-G11iN18-scFv16 in TL-state 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody fragment scFv16, Fractalkine, ... 著者 Tsutsumi, N, Maeda, S, Qu, Q, Skiniotis, G, Kobilka, B.K, Garcia, K.C. 登録日 2021-07-22 公開日 2022-01-26 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins Sci Adv, 8, 2022
7RKM	Structure of CX3CL1-US28-Gi-scFv16 in C-state 分子名称: Antibody fragment scFv16, CHOLESTEROL, Fractalkine, ... 著者 Tsutsumi, N, Qu, Q, Jude, K.M, Skiniotis, G, Garcia, K.C. 登録日 2021-07-22 公開日 2022-01-26 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins Sci Adv, 8, 2022

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