6NPZ
| Crystal structure of Akt1 (aa 123-480) kinase with a bisubstrate | 分子名称: | GLYCEROL, MANGANESE (II) ION, RAC-alpha serine/threonine-protein kinase, ... | 著者 | Chu, N, Cole, P.A, Gabelli, S.B. | 登録日 | 2019-01-18 | 公開日 | 2019-01-30 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | 主引用文献 | Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis. Cell, 174, 2018
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5YK3
| human Ragulator complex | 分子名称: | Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, Ragulator complex protein LAMTOR3, ... | 著者 | Wu, G, Mu, Z. | 登録日 | 2017-10-12 | 公開日 | 2019-01-23 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (3.01 Å) | 主引用文献 | Structural insight into the Ragulator complex which anchors mTORC1 to the lysosomal membrane Cell Discov, 3, 2017
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5YK5
| structure of the human Lamtor4-Lamtor5 complex | 分子名称: | Ragulator complex protein LAMTOR4, Ragulator complex protein LAMTOR5 | 著者 | Wu, G, Mu, Z. | 登録日 | 2017-10-12 | 公開日 | 2018-12-12 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Structural insight into the Ragulator complex which anchors mTORC1 to the lysosomal membrane Cell Discov, 3, 2017
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6E7F
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5ZXB
| Crystal structure of ACK1 with compound 10d | 分子名称: | Activated CDC42 kinase 1, N-{3-[7-{[6-(4-acetylpiperazin-1-yl)pyridin-3-yl]amino}-1-methyl-2-oxo-1,4-dihydropyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl}-3-(trifluoromethyl)benzamide | 著者 | Hong, E.M, Kim, H.L, Sim, T.B. | 登録日 | 2018-05-18 | 公開日 | 2018-09-26 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.198 Å) | 主引用文献 | First SAR Study for Overriding NRAS Mutant Driven Acute Myeloid Leukemia. J. Med. Chem., 61, 2018
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6BUU
| Crystal structure of AKT1 (aa 144-480) with a bisubstrate | 分子名称: | GLY-ARG-PRO-ARG-THR-THR-ZXW-PHE-ALA-GLU, MANGANESE (II) ION, RAC-alpha serine/threonine-protein kinase, ... | 著者 | Chu, N, Gabelli, S.B, Cole, P.A. | 登録日 | 2017-12-11 | 公開日 | 2018-08-22 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis. Cell, 174, 2018
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5VOK
| Crystal structure of the C7orf59-HBXIP dimer | 分子名称: | Ragulator complex protein LAMTOR4, Ragulator complex protein LAMTOR5 | 著者 | Rasheed, N, Nascimento, A.F.Z, Bar-Peled, L, Shen, K, Sabatini, D.M, Aparicio, R, Smetana, J.H.C. | 登録日 | 2017-05-03 | 公開日 | 2018-05-23 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.89 Å) | 主引用文献 | C7orf59/Lamtor4 phosphorylation and structural flexibility modulate Ragulator assembly. Febs Open Bio, 2019
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6FO1
| Human R2TP subcomplex containing 1 RUVBL1-RUVBL2 hexamer bound to 1 RBD domain from RPAP3. | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, RNA polymerase II-associated protein 3, RuvB-like 1, ... | 著者 | Martino, F, Munoz-Hernandez, H, Rodriguez, C.F, Pearl, L.H, Llorca, O. | 登録日 | 2018-02-05 | 公開日 | 2018-04-04 | 最終更新日 | 2019-12-11 | 実験手法 | ELECTRON MICROSCOPY (3.57 Å) | 主引用文献 | RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex. Nat Commun, 9, 2018
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6CHZ
| Estrogen Receptor Alpha Y537S bound to antagonist H3B-9224. | 分子名称: | 1,2-ETHANEDIOL, 4-[(2-{4-[(1E)-1-(1H-indazol-5-yl)-2-phenylbut-1-en-1-yl]phenoxy}ethyl)amino]-N,N-dimethylbutanamide, Estrogen receptor | 著者 | Larsen, N.A. | 登録日 | 2018-02-23 | 公開日 | 2018-03-21 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | 主引用文献 | Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ER alphaWTand ER alphaMUTBreast Cancer. Cancer Discov, 8, 2018
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6CHW
| Estrogen Receptor Alpha Y537S covalently bound to antagonist H3B-5942. | 分子名称: | 1,2-ETHANEDIOL, 4-[(2-{4-[(1E)-1-(1H-indazol-5-yl)-2-phenylbut-1-en-1-yl]phenoxy}ethyl)amino]-N,N-dimethylbutanamide, DIMETHYL SULFOXIDE, ... | 著者 | Larsen, N.A. | 登録日 | 2018-02-23 | 公開日 | 2018-03-21 | 最終更新日 | 2020-02-26 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ER alphaWTand ER alphaMUTBreast Cancer. Cancer Discov, 8, 2018
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5ZCS
| 4.9 Angstrom Cryo-EM structure of human mTOR complex 2 | 分子名称: | Rapamycin-insensitive companion of mTOR, Serine/threonine-protein kinase mTOR, Target of rapamycin complex 2 subunit MAPKAP1, ... | 著者 | Chen, X, Liu, M, Tian, Y, Wang, H, Wang, J, Xu, Y. | 登録日 | 2018-02-20 | 公開日 | 2018-03-21 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4.9 Å) | 主引用文献 | Cryo-EM structure of human mTOR complex 2. Cell Res., 28, 2018
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5Y3A
| Crystal structure of Ragulator complex (p18 49-161) | 分子名称: | Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, Ragulator complex protein LAMTOR3, ... | 著者 | Zhang, T, Ding, J. | 登録日 | 2017-07-28 | 公開日 | 2017-12-27 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1. Nat Commun, 8, 2017
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5WBU
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5WBJ
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5WBY
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6BCX
| mTORC1 structure refined to 3.0 angstroms | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Eukaryotic translation initiation factor 4E-binding protein 1, MAGNESIUM ION, ... | 著者 | Pavletich, N.P, Yang, H. | 登録日 | 2017-10-20 | 公開日 | 2017-12-20 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.23 Å) | 主引用文献 | Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
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6BCU
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5WBL
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5WBH
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5WBK
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5WBI
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5NDV
| Crystal structure of Paromomycin bound to the yeast 80S ribosome | 分子名称: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | 著者 | Prokhorova, I, Djumagulov, M, Urzhumtsev, A, Yusupov, M, Yusupova, G. | 登録日 | 2017-03-09 | 公開日 | 2017-12-13 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Aminoglycoside interactions and impacts on the eukaryotic ribosome. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5OBM
| Crystal structure of Gentamicin bound to the yeast 80S ribosome | 分子名称: | (2R,3R,4R,5R)-2-((1S,2S,3R,4S,6R)-4,6-DIAMINO-3-((2R,3R,6S)-3-AMINO-6-(AMINOMETHYL)-TETRAHYDRO-2H-PYRAN-2-YLOXY)-2-HYDR OXYCYCLOHEXYLOXY)-5-METHYL-4-(METHYLAMINO)-TETRAHYDRO-2H-PYRAN-3,5-DIOL, 18S ribosomal RNA, 25S ribosomal RNA, ... | 著者 | Prokhorova, I, Djumagulov, M, Urzhumtsev, A, Yusupov, M, Yusupova, G. | 登録日 | 2017-06-28 | 公開日 | 2017-12-13 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Aminoglycoside interactions and impacts on the eukaryotic ribosome. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5X6U
| Crystal structure of human heteropentameric complex | 分子名称: | Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, Ragulator complex protein LAMTOR3, ... | 著者 | Yonehara, R, Nada, S, Nakai, T, Nakai, M, Kitamura, A, Ogawa, A, Nakatsumi, H, Nakayama, K.I, Li, S, Standley, D.M, Yamashita, E, Nakagawa, A, Okada, M. | 登録日 | 2017-02-23 | 公開日 | 2017-12-06 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural basis for the assembly of the Ragulator-Rag GTPase complex. Nat Commun, 8, 2017
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5X6V
| Crystal structure of human heteroheptameric complex | 分子名称: | ACETATE ION, Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, ... | 著者 | Yonehara, R, Nada, S, Nakai, T, Nakai, M, Kitamura, A, Ogawa, A, Nakatsumi, H, Nakayama, K.I, Li, S, Standley, D.M, Yamashita, E, Nakagawa, A, Okada, M. | 登録日 | 2017-02-23 | 公開日 | 2017-12-06 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | 主引用文献 | Structural basis for the assembly of the Ragulator-Rag GTPase complex. Nat Commun, 8, 2017
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