PDB: 267 件ウェブページステータス検索Chemie searchBIRD

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6NPZ	Crystal structure of Akt1 (aa 123-480) kinase with a bisubstrate 分子名称: GLYCEROL, MANGANESE (II) ION, RAC-alpha serine/threonine-protein kinase, ... 著者 Chu, N, Cole, P.A, Gabelli, S.B. 登録日 2019-01-18 公開日 2019-01-30 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.12 Å) 主引用文献 Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis. Cell, 174, 2018
5YK3	human Ragulator complex 分子名称: Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, Ragulator complex protein LAMTOR3, ... 著者 Wu, G, Mu, Z. 登録日 2017-10-12 公開日 2019-01-23 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (3.01 Å) 主引用文献 Structural insight into the Ragulator complex which anchors mTORC1 to the lysosomal membrane Cell Discov, 3, 2017
5YK5	structure of the human Lamtor4-Lamtor5 complex 分子名称: Ragulator complex protein LAMTOR4, Ragulator complex protein LAMTOR5 著者 Wu, G, Mu, Z. 登録日 2017-10-12 公開日 2018-12-12 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 Structural insight into the Ragulator complex which anchors mTORC1 to the lysosomal membrane Cell Discov, 3, 2017
6E7F	Crystal Structure of Human Inositol Polyphosphate Multikinase (IPMK) Catalytic Core Domain 分子名称: Inositol polyphosphate multikinase, SULFATE ION 著者 Blind, R, Seacrist, C. 登録日 2018-07-26 公開日 2018-11-07 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystallographic and kinetic analyses of human IPMK reveal disordered domains modulate ATP binding and kinase activity. Sci Rep, 8, 2018
5ZXB	Crystal structure of ACK1 with compound 10d 分子名称: Activated CDC42 kinase 1, N-{3-[7-{[6-(4-acetylpiperazin-1-yl)pyridin-3-yl]amino}-1-methyl-2-oxo-1,4-dihydropyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl}-3-(trifluoromethyl)benzamide 著者 Hong, E.M, Kim, H.L, Sim, T.B. 登録日 2018-05-18 公開日 2018-09-26 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.198 Å) 主引用文献 First SAR Study for Overriding NRAS Mutant Driven Acute Myeloid Leukemia. J. Med. Chem., 61, 2018
6BUU	Crystal structure of AKT1 (aa 144-480) with a bisubstrate 分子名称: GLY-ARG-PRO-ARG-THR-THR-ZXW-PHE-ALA-GLU, MANGANESE (II) ION, RAC-alpha serine/threonine-protein kinase, ... 著者 Chu, N, Gabelli, S.B, Cole, P.A. 登録日 2017-12-11 公開日 2018-08-22 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis. Cell, 174, 2018
5VOK	Crystal structure of the C7orf59-HBXIP dimer 分子名称: Ragulator complex protein LAMTOR4, Ragulator complex protein LAMTOR5 著者 Rasheed, N, Nascimento, A.F.Z, Bar-Peled, L, Shen, K, Sabatini, D.M, Aparicio, R, Smetana, J.H.C. 登録日 2017-05-03 公開日 2018-05-23 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.89 Å) 主引用文献 C7orf59/Lamtor4 phosphorylation and structural flexibility modulate Ragulator assembly. Febs Open Bio, 2019
6FO1	Human R2TP subcomplex containing 1 RUVBL1-RUVBL2 hexamer bound to 1 RBD domain from RPAP3. 分子名称: ADENOSINE-5'-DIPHOSPHATE, RNA polymerase II-associated protein 3, RuvB-like 1, ... 著者 Martino, F, Munoz-Hernandez, H, Rodriguez, C.F, Pearl, L.H, Llorca, O. 登録日 2018-02-05 公開日 2018-04-04 最終更新日 2019-12-11 実験手法 ELECTRON MICROSCOPY (3.57 Å) 主引用文献 RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex. Nat Commun, 9, 2018
6CHZ	Estrogen Receptor Alpha Y537S bound to antagonist H3B-9224. 分子名称: 1,2-ETHANEDIOL, 4-[(2-{4-[(1E)-1-(1H-indazol-5-yl)-2-phenylbut-1-en-1-yl]phenoxy}ethyl)amino]-N,N-dimethylbutanamide, Estrogen receptor 著者 Larsen, N.A. 登録日 2018-02-23 公開日 2018-03-21 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ER alphaWTand ER alphaMUTBreast Cancer. Cancer Discov, 8, 2018
6CHW	Estrogen Receptor Alpha Y537S covalently bound to antagonist H3B-5942. 分子名称: 1,2-ETHANEDIOL, 4-[(2-{4-[(1E)-1-(1H-indazol-5-yl)-2-phenylbut-1-en-1-yl]phenoxy}ethyl)amino]-N,N-dimethylbutanamide, DIMETHYL SULFOXIDE, ... 著者 Larsen, N.A. 登録日 2018-02-23 公開日 2018-03-21 最終更新日 2020-02-26 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ER alphaWTand ER alphaMUTBreast Cancer. Cancer Discov, 8, 2018
5ZCS	4.9 Angstrom Cryo-EM structure of human mTOR complex 2 分子名称: Rapamycin-insensitive companion of mTOR, Serine/threonine-protein kinase mTOR, Target of rapamycin complex 2 subunit MAPKAP1, ... 著者 Chen, X, Liu, M, Tian, Y, Wang, H, Wang, J, Xu, Y. 登録日 2018-02-20 公開日 2018-03-21 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (4.9 Å) 主引用文献 Cryo-EM structure of human mTOR complex 2. Cell Res., 28, 2018
5Y3A	Crystal structure of Ragulator complex (p18 49-161) 分子名称: Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, Ragulator complex protein LAMTOR3, ... 著者 Zhang, T, Ding, J. 登録日 2017-07-28 公開日 2017-12-27 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1. Nat Commun, 8, 2017
5WBU	Crystal structure of mTOR(deltaN)-mLST8-PRAS40(alpha-helix & beta-strand) complex 分子名称: Proline-rich AKT1 substrate 1, Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8 著者 Pavletich, N.P, Yang, H. 登録日 2017-06-29 公開日 2017-12-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.42 Å) 主引用文献 Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
5WBJ	Crystal structure of the arabidopsis thaliana Raptor in complex with the TOS peptide of human 4EBP1 分子名称: Eukaryotic translation initiation factor 4E-binding protein 1, Regulatory-associated protein of TOR 1 著者 Pavletich, N.P, Jiang, X. 登録日 2017-06-29 公開日 2017-12-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
5WBY	Crystal structure of mTOR(deltaN)-mLST8-PRAS40(beta-strand) complex 分子名称: Proline-rich AKT1 substrate 1, Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8 著者 Pavletich, N.P, Yang, H. 登録日 2017-06-29 公開日 2017-12-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
6BCX	mTORC1 structure refined to 3.0 angstroms 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Eukaryotic translation initiation factor 4E-binding protein 1, MAGNESIUM ION, ... 著者 Pavletich, N.P, Yang, H. 登録日 2017-10-20 公開日 2017-12-20 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.23 Å) 主引用文献 Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
6BCU	Cryo-EM structure of the activated RHEB-mTORC1 refined to 3.4 angstrom 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Eukaryotic translation initiation factor 4E-binding protein 1, GTP-binding protein Rheb, ... 著者 Pavletich, N.P, Yang, H. 登録日 2017-10-20 公開日 2017-12-20 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
5WBL	Crystal structure of the Arabidopsis thaliana Raptor in complex with the TOS peptide of human PRAS40 分子名称: Proline-rich AKT1 substrate 1, Regulatory-associated protein of TOR 1 著者 Pavletich, N.P, Jiang, X. 登録日 2017-06-29 公開日 2017-12-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.35 Å) 主引用文献 Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
5WBH	Structure of the FRB domain of mTOR bound to a substrate recruitment peptide of S6K1 分子名称: Ribosomal protein S6 kinase beta-1, Serine/threonine-protein kinase mTOR 著者 Pavletich, N.P, Yang, H. 登録日 2017-06-29 公開日 2017-12-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
5WBK	Crystal structure of the arabidopsis thaliana Raptor in complex with the TOS peptide of human S6K1 分子名称: Regulatory-associated protein of TOR 1, Ribosomal protein S6 kinase beta-1 著者 Pavletich, N.P, Jiang, X. 登録日 2017-06-29 公開日 2017-12-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.11 Å) 主引用文献 Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
5WBI	Crystal structure of the Arabidopsis thaliana Raptor 分子名称: Regulatory-associated protein of TOR 1 著者 Pavletich, N.P, Jiang, X. 登録日 2017-06-29 公開日 2017-12-20 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
5NDV	Crystal structure of Paromomycin bound to the yeast 80S ribosome 分子名称: 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... 著者 Prokhorova, I, Djumagulov, M, Urzhumtsev, A, Yusupov, M, Yusupova, G. 登録日 2017-03-09 公開日 2017-12-13 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Aminoglycoside interactions and impacts on the eukaryotic ribosome. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5OBM	Crystal structure of Gentamicin bound to the yeast 80S ribosome 分子名称: (2R,3R,4R,5R)-2-((1S,2S,3R,4S,6R)-4,6-DIAMINO-3-((2R,3R,6S)-3-AMINO-6-(AMINOMETHYL)-TETRAHYDRO-2H-PYRAN-2-YLOXY)-2-HYDR OXYCYCLOHEXYLOXY)-5-METHYL-4-(METHYLAMINO)-TETRAHYDRO-2H-PYRAN-3,5-DIOL, 18S ribosomal RNA, 25S ribosomal RNA, ... 著者 Prokhorova, I, Djumagulov, M, Urzhumtsev, A, Yusupov, M, Yusupova, G. 登録日 2017-06-28 公開日 2017-12-13 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Aminoglycoside interactions and impacts on the eukaryotic ribosome. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5X6U	Crystal structure of human heteropentameric complex 分子名称: Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, Ragulator complex protein LAMTOR3, ... 著者 Yonehara, R, Nada, S, Nakai, T, Nakai, M, Kitamura, A, Ogawa, A, Nakatsumi, H, Nakayama, K.I, Li, S, Standley, D.M, Yamashita, E, Nakagawa, A, Okada, M. 登録日 2017-02-23 公開日 2017-12-06 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural basis for the assembly of the Ragulator-Rag GTPase complex. Nat Commun, 8, 2017
5X6V	Crystal structure of human heteroheptameric complex 分子名称: ACETATE ION, Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, ... 著者 Yonehara, R, Nada, S, Nakai, T, Nakai, M, Kitamura, A, Ogawa, A, Nakatsumi, H, Nakayama, K.I, Li, S, Standley, D.M, Yamashita, E, Nakagawa, A, Okada, M. 登録日 2017-02-23 公開日 2017-12-06 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 Structural basis for the assembly of the Ragulator-Rag GTPase complex. Nat Commun, 8, 2017

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