7NFJ
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7NFF
| An octameric barrel state of a de novo coiled-coil assembly: CC-Type2-(LaId)4-I24A. | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CC-Type2-(LaId)4-I24A, GLYCEROL | Authors: | Rhys, G.G, Dawson, W.M, Brady, R.L, Woolfson, D.N. | Deposit date: | 2021-02-07 | Release date: | 2022-03-02 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Differential sensing with arrays of de novo designed peptide assemblies. Nat Commun, 14, 2023
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7NFO
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7NFM
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1IVL
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3P6I
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3VJF
| Crystal structure of de novo 4-helix bundle protein WA20 | Descriptor: | POTASSIUM ION, WA20 | Authors: | Arai, R, Kimura, A, Kobayashi, N, Matsuo, K, Sato, T, Wang, A.F, Platt, J.M, Bradley, L.H, Hecht, M.H. | Deposit date: | 2011-10-18 | Release date: | 2012-03-28 | Last modified: | 2017-11-22 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Domain-swapped dimeric structure of a stable and functional de novo four-helix bundle protein, WA20 J.Phys.Chem.B, 116, 2012
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7AH0
| Crystal structure of the de novo designed two-heme binding protein, 4D2 | Descriptor: | 4D2, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Hutchins, G.H, Parnell, A.E, Anderson, J.L.R. | Deposit date: | 2020-09-23 | Release date: | 2021-10-06 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | An expandable, modular de novo protein platform for precision redox engineering. Proc.Natl.Acad.Sci.USA, 120, 2023
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3RA3
| Crystal structure of a section of a de novo design gigaDalton protein fibre | Descriptor: | SODIUM ION, p1c, p2f | Authors: | Zaccai, N.R, Sharp, T.H, Bruning, M, Woolfson, D.N, Brady, R.L. | Deposit date: | 2011-03-27 | Release date: | 2012-08-08 | Last modified: | 2013-06-19 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Cryo-transmission electron microscopy structure of a gigadalton peptide fiber of de novo design Proc.Natl.Acad.Sci.USA, 109, 2012
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8CCR
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4DZN
| A de novo designed Coiled Coil CC-pIL | Descriptor: | COILED-COIL PEPTIDE CC-PIL | Authors: | Bruning, M, Thomson, A.R, Zaccai, N.R, Brady, R.L, Woolfson, D.N. | Deposit date: | 2012-03-01 | Release date: | 2012-08-29 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | A basis set of de novo coiled-coil Peptide oligomers for rational protein design and synthetic biology. ACS Synth Biol, 1, 2012
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4DZM
| A de novo designed Coiled Coil CC-Di | Descriptor: | COILED-COIL PEPTIDE CC-DI | Authors: | Bruning, M, Thomson, A.R, Zaccai, N.R, Brady, R.L, Woolfson, D.N. | Deposit date: | 2012-03-01 | Release date: | 2012-08-29 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | A basis set of de novo coiled-coil Peptide oligomers for rational protein design and synthetic biology. ACS Synth Biol, 1, 2012
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4DZK
| A de novo designed Coiled Coil CC-Tri-N13 | Descriptor: | CHLORIDE ION, COILED-COIL PEPTIDE CC-TRI-N13 | Authors: | Bruning, M, Thomson, A.R, Zaccai, N.R, Brady, R.L, Woolfson, D.N. | Deposit date: | 2012-03-01 | Release date: | 2012-08-29 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | A basis set of de novo coiled-coil Peptide oligomers for rational protein design and synthetic biology. ACS Synth Biol, 1, 2012
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4DZL
| A de novo designed Coiled Coil CC-Tri | Descriptor: | COILED-COIL PEPTIDE CC-TRI | Authors: | Bruning, M, Thomson, A.R, Zaccai, N.R, Brady, R.L, Woolfson, D.N. | Deposit date: | 2012-03-01 | Release date: | 2012-08-29 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | A basis set of de novo coiled-coil Peptide oligomers for rational protein design and synthetic biology. ACS Synth Biol, 1, 2012
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5TX8
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3B83
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3UD6
| Structural analyses of covalent enzyme-substrate analogue complexes reveal strengths and limitations of de novo enzyme design | Descriptor: | 1-(6-METHOXYNAPHTHALEN-2-YL)BUTANE-1,3-DIONE, RETRO-ALDOLASE, SULFATE ION | Authors: | Baker, D, Stoddard, B.L, Althoff, E.A, Wang, L, Jiang, L, Moody, J, Bolduc, J, Lassila, J, Hilvert, D. | Deposit date: | 2011-10-27 | Release date: | 2011-11-23 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.091 Å) | Cite: | Structural analyses of covalent enzyme-substrate analog complexes reveal strengths and limitations of de novo enzyme design. J.Mol.Biol., 415, 2012
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6XXV
| Crystal Structure of a computationally designed Immunogen S2_1.2 in complex with its elicited antibody C57 | Descriptor: | Antibody C57, Heavy Chain, Light Chain, ... | Authors: | Yang, C, Sesterhenn, F, Correia, B.E, Pojer, F. | Deposit date: | 2020-01-28 | Release date: | 2020-04-22 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.20116425 Å) | Cite: | De novo protein design enables the precise induction of RSV-neutralizing antibodies. Science, 368, 2020
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8ETQ
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7SQ4
| Designed trefoil knot protein, variant 2 | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Designed trefoil knot protein, variant 2, ... | Authors: | Takushi, B, Doyle, L, Stoddard, B.L, Bradley, P. | Deposit date: | 2021-11-04 | Release date: | 2022-06-29 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.493 Å) | Cite: | De novo design of knotted tandem repeat proteins. Nat Commun, 14, 2023
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8EVM
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7SQ3
| Designed trefoil knot protein, variant 1 | Descriptor: | CHLORIDE ION, Designed trefoil knot protein, variant 1, ... | Authors: | Takushi, B, Doyle, L, Stoddard, B.L, Bradley, P. | Deposit date: | 2021-11-04 | Release date: | 2022-06-29 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.453 Å) | Cite: | De novo design of knotted tandem repeat proteins. Nat Commun, 14, 2023
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7SQ5
| Designed trefoil knot protein, variant 3 | Descriptor: | Designed trefoil knot protein, variant 3, SODIUM ION | Authors: | Takushi, B, Doyle, L, Stoddard, B.L, Bradley, P. | Deposit date: | 2021-11-04 | Release date: | 2022-11-09 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.205 Å) | Cite: | De novo design of knotted tandem repeat proteins. Nat Commun, 14, 2023
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8GL3
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5F72
| De novo design and crystallographic validation of antibodies targeting a pre-selected epitope | Descriptor: | Kelch-like ECH-associated protein 1, Single chain Fv from a Fab | Authors: | Liu, X, Taylor, R.D, Griffin, L, Coker, S, Adams, R, Ceska, T, Shi, J, Lawson, A.D.G, Baker, T. | Deposit date: | 2015-12-07 | Release date: | 2016-12-14 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | De novo design and crystallographic validation of antibodies targeting a pre-selected epitope To Be Published
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