5JER
 
 | | Structure of Rotavirus NSP1 bound to IRF-3 | | Descriptor: | Interferon regulatory factor 3, Rotavirus NSP1 peptide | | Authors: | Zhao, B, Li, P. | | Deposit date: | 2016-04-18 | | Release date: | 2016-06-15 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2.913 Å) | | Cite: | Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins.
Proc.Natl.Acad.Sci.USA, 113, 2016
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5JEJ
 | | Phosphorylated STING in complex with IRF-3 CTD | | Descriptor: | Interferon regulatory factor 3, Stimulator of interferon genes protein | | Authors: | Li, P, Shu, C. | | Deposit date: | 2016-04-18 | | Release date: | 2016-06-15 | | Last modified: | 2016-06-29 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins.
Proc.Natl.Acad.Sci.USA, 113, 2016
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3B0D
 | | Crystal structure of the chicken CENP-T histone fold/CENP-W complex, crystal form II | | Descriptor: | CITRIC ACID, Centromere protein T, Centromere protein W | | Authors: | Nishino, T, Takeuchi, K, Gascoigne, K.E, Suzuki, A, Hori, T, Oyama, T, Morikawa, K, Cheeseman, I.M, Fukagawa, T. | | Deposit date: | 2011-06-08 | | Release date: | 2012-03-07 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.197 Å) | | Cite: | CENP-T-W-S-X Forms a Unique Centromeric Chromatin Structure with a Histone-like Fold.
Cell(Cambridge,Mass.), 148, 2012
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1ORC
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5H99
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5H9I
 | | Crystal structure of Geobacter metallireducens SMUG1 with xanthine | | Descriptor: | BETA-MERCAPTOETHANOL, GLYCEROL, Geobacter metallireducens SMUG1, ... | | Authors: | Xie, W, Cao, W, Zhang, Z, Shen, J. | | Deposit date: | 2015-12-28 | | Release date: | 2016-04-27 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.501 Å) | | Cite: | Structural Basis of Substrate Specificity in Geobacter metallireducens SMUG1
Acs Chem.Biol., 11, 2016
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1NQ2
 | | Two RTH Mutants with Impaired Hormone Binding | | Descriptor: | ARSENIC, SODIUM ION, Thyroid hormone receptor beta-1, ... | | Authors: | Huber, B.R, Sandler, B, West, B.L, Cunha-Lima, S.T, Nguyen, H.T, Apriletti, J.W, Baxter, J.D, Fletterick, R.J. | | Deposit date: | 2003-01-21 | | Release date: | 2003-04-15 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Two resistance to thyroid hormone mutants with impaired hormone binding
Mol.Endocrinol., 17, 2003
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3C28
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8B3I
 | | CRL4CSA-E2-Ub (state 2) | | Descriptor: | Cullin-4A, DNA damage-binding protein 1, DNA excision repair protein ERCC-8, ... | | Authors: | Kokic, G, Cramer, P. | | Deposit date: | 2022-09-16 | | Release date: | 2023-09-27 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | C(N)RL4CSA-E2-Ub (state 2)
To Be Published
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6LW3
 | | Crystal structure of RuvC from Pseudomonas aeruginosa | | Descriptor: | Crossover junction endodeoxyribonuclease RuvC | | Authors: | Hu, Y, He, Y, Lin, Z. | | Deposit date: | 2020-02-07 | | Release date: | 2020-02-26 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.38 Å) | | Cite: | Biochemical and structural characterization of the Holliday junction resolvase RuvC from Pseudomonas aeruginosa.
Biochem.Biophys.Res.Commun., 525, 2020
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5F4N
 | | Multi-parameter lead optimization to give an oral CHK1 inhibitor clinical candidate: (R)-5-((4-((morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737) | | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, Serine/threonine-protein kinase Chk1, ... | | Authors: | Collins, I, Garrett, M.D, van Montfort, R, Osborne, J.D, Matthews, T.P, McHardy, T, Proisy, N, Cheung, K.J, Lainchbury, M, Brown, N, Walton, M.I, Eve, P.D, Boxall, K.J, Hayes, A, Henley, A.T, Valenti, M.R, De Haven Brandon, A.K, Box, G, Westwood, I.M, Jamin, Y, Robinson, S.P, Leonard, P, Reader, J.C, Aherne, G.W, Raynaud, F.I, Eccles, S.A. | | Deposit date: | 2015-12-03 | | Release date: | 2016-05-25 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.91 Å) | | Cite: | Multiparameter Lead Optimization to Give an Oral Checkpoint Kinase 1 (CHK1) Inhibitor Clinical Candidate: (R)-5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737).
J.Med.Chem., 59, 2016
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6B1G
 | | Solution structure of TDP-43 N-terminal domain dimer. | | Descriptor: | TAR DNA-binding protein 43, S48E Mutant, Y4R Mutant | | Authors: | Naik, M.T, Wang, A, Conicella, A, Fawzi, N.L. | | Deposit date: | 2017-09-18 | | Release date: | 2018-02-28 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | A single N-terminal phosphomimic disrupts TDP-43 polymerization, phase separation, and RNA splicing.
EMBO J., 37, 2018
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6M3G
 | | Crystal structure of human HPF1 | | Descriptor: | Histone PARylation factor 1 | | Authors: | Sun, F.H, Yun, C.H. | | Deposit date: | 2020-03-03 | | Release date: | 2021-03-03 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.57 Å) | | Cite: | HPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histones.
Nat Commun, 12, 2021
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6M3H
 | | Crystal structure of mouse HPF1 | | Descriptor: | Histone PARylation factor 1 | | Authors: | Sun, F.H, Yun, C.H. | | Deposit date: | 2020-03-03 | | Release date: | 2021-03-03 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.71 Å) | | Cite: | HPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histones.
Nat Commun, 12, 2021
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4Y13
 | | SdiA in complex with octanoyl-rac-glycerol | | Descriptor: | (2S)-2,3-dihydroxypropyl octanoate, GLYCEROL, SULFATE ION, ... | | Authors: | Nguyen, N.X, Nguyen, Y, Sperandio, V, Jiang, Y. | | Deposit date: | 2015-02-06 | | Release date: | 2015-04-08 | | Last modified: | 2019-12-04 | | Method: | X-RAY DIFFRACTION (3.096 Å) | | Cite: | Structural and Mechanistic Roles of Novel Chemical Ligands on the SdiA Quorum-Sensing Transcription Regulator.
Mbio, 6, 2015
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1G18
 | | RECA-ADP-ALF4 COMPLEX | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, RECA PROTEIN, TETRAFLUOROALUMINATE ION | | Authors: | Datta, S, Prabu, M.M, Vaze, M.B, Ganesh, N, Chandra, N.R, Muniyappa, K, Vijayan, M, TB Structural Genomics Consortium (TBSGC) | | Deposit date: | 2000-10-11 | | Release date: | 2000-12-11 | | Last modified: | 2018-04-04 | | Method: | X-RAY DIFFRACTION (3.8 Å) | | Cite: | Crystal structures of Mycobacterium tuberculosis RecA and its complex with ADP-AlF(4): implications for decreased ATPase activity and molecular aggregation
Nucleic Acids Res., 28, 2000
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5Y81
 | | NuA4 TEEAA sub-complex | | Descriptor: | Actin, Actin-related protein 4, Chromatin modification-related protein EAF1, ... | | Authors: | Wang, X, Cai, G. | | Deposit date: | 2017-08-18 | | Release date: | 2018-04-18 | | Last modified: | 2019-11-06 | | Method: | ELECTRON MICROSCOPY (4.7 Å) | | Cite: | Architecture of the Saccharomyces cerevisiae NuA4/TIP60 complex
Nat Commun, 9, 2018
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8Q1X
 | | Structural analysis of PLD3 reveals insights into the mechanism of lysosomal 5' exonuclease-mediated nucleic acid degradation | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5'-3' exonuclease PLD3, ... | | Authors: | Roske, Y, Daumke, O, Damme, M. | | Deposit date: | 2023-08-01 | | Release date: | 2023-12-06 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Structural analysis of PLD3 reveals insights into the mechanism of lysosomal 5' exonuclease-mediated nucleic acid degradation.
Nucleic Acids Res., 52, 2024
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5C8D
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5Y7Y
 | | Crystal structure of AhRR/ARNT complex | | Descriptor: | Aryl hydrocarbon receptor nuclear translocator, Aryl hydrocarbon receptor repressor, GLYCEROL | | Authors: | Sakurai, S, Shimizu, T, Ohto, U. | | Deposit date: | 2017-08-18 | | Release date: | 2017-09-20 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | The crystal structure of the AhRR-ARNT heterodimer reveals the structural basis of the repression of AhR-mediated transcription.
J. Biol. Chem., 292, 2017
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4P78
 | | HicA3 and HicB3 toxin-antitoxin complex | | Descriptor: | GLYCEROL, HicA3 Toxin, HicB3 antitoxin | | Authors: | Li de la Sierra-Gallay, I, Bibi-Triki, S, van Tilbeurgh, H, Lazar, N, Pradel, E. | | Deposit date: | 2014-03-26 | | Release date: | 2014-08-27 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.12 Å) | | Cite: | Functional and Structural Analysis of HicA3-HicB3, a Novel Toxin-Antitoxin System of Yersinia pestis.
J.Bacteriol., 196, 2014
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4P7D
 | | Antitoxin HicB3 crystal structure | | Descriptor: | Antitoxin HicB3, CHLORIDE ION | | Authors: | Li de la Sierra-Gallay, I, Bibi-Triki, S, van Tilbeurgh, H, Lazar, N, Pradel, E. | | Deposit date: | 2014-03-27 | | Release date: | 2014-08-27 | | Last modified: | 2015-02-04 | | Method: | X-RAY DIFFRACTION (2.781 Å) | | Cite: | Functional and Structural Analysis of HicA3-HicB3, a Novel Toxin-Antitoxin System of Yersinia pestis.
J.Bacteriol., 196, 2014
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7K7T
 | | Crystal structure of human MORC4 ATPase-CW in complex with AMPPNP | | Descriptor: | Isoform 3 of MORC family CW-type zinc finger protein 4, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | Authors: | Klein, B.J, Tencer, A.H, Kutateladze, T.G. | | Deposit date: | 2020-09-24 | | Release date: | 2020-11-11 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.94 Å) | | Cite: | Molecular mechanism of the MORC4 ATPase activation.
Nat Commun, 11, 2020
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8Q1K
 | | Structural analysis of PLD3 reveals insights into the mechanism of lysosomal 5' exonuclease-mediated nucleic acid degradation | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5'-3' exonuclease PLD3, ... | | Authors: | Roske, Y, Daumke, O, Damme, M. | | Deposit date: | 2023-07-31 | | Release date: | 2023-12-06 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.51 Å) | | Cite: | Structural analysis of PLD3 reveals insights into the mechanism of lysosomal 5' exonuclease-mediated nucleic acid degradation.
Nucleic Acids Res., 52, 2024
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1G19
 | | STRUCTURE OF RECA PROTEIN | | Descriptor: | PHOSPHATE ION, RECA PROTEIN | | Authors: | Datta, S, Prabu, M.M, Vaze, M.B, Ganesh, N, Chandra, N.R, Muniyappa, K, Vijayan, M, TB Structural Genomics Consortium (TBSGC) | | Deposit date: | 2000-10-11 | | Release date: | 2000-12-11 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Crystal structures of Mycobacterium tuberculosis RecA and its complex with ADP-AlF(4): implications for decreased ATPase activity and molecular aggregation
Nucleic Acids Res., 28, 2000
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