8Q1X
Structural analysis of PLD3 reveals insights into the mechanism of lysosomal 5' exonuclease-mediated nucleic acid degradation
Summary for 8Q1X
Entry DOI | 10.2210/pdb8q1x/pdb |
Descriptor | 5'-3' exonuclease PLD3, alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total) |
Functional Keywords | pld3, structural biology, lysosome, dna/rna degradation, phospholipase d, 5' exonuclease, dna binding protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 102486.68 |
Authors | Roske, Y.,Daumke, O.,Damme, M. (deposition date: 2023-08-01, release date: 2023-12-06, Last modification date: 2024-01-24) |
Primary citation | Roske, Y.,Cappel, C.,Cremer, N.,Hoffmann, P.,Koudelka, T.,Tholey, A.,Heinemann, U.,Daumke, O.,Damme, M. Structural analysis of PLD3 reveals insights into the mechanism of lysosomal 5' exonuclease-mediated nucleic acid degradation. Nucleic Acids Res., 52:370-384, 2024 Cited by PubMed: 37994783DOI: 10.1093/nar/gkad1114 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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