8Q1X
Structural analysis of PLD3 reveals insights into the mechanism of lysosomal 5' exonuclease-mediated nucleic acid degradation
Functional Information from GO Data
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor => ECO:0000255|PROSITE-ProRule:PRU00153 |
| Chain | Residue | Details |
| A | HIS201 | |
| B | HIS201 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU00153 |
| Chain | Residue | Details |
| A | LYS203 | |
| A | ASP208 | |
| B | LYS203 | |
| B | ASP208 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | ACT_SITE: Nucleophile => ECO:0000250|UniProtKB:O35405 |
| Chain | Residue | Details |
| A | HIS416 | |
| B | HIS416 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:O35405 |
| Chain | Residue | Details |
| A | HIS201 | |
| A | LYS203 | |
| A | ASN218 | |
| A | HIS416 | |
| B | HIS201 | |
| B | LYS203 | |
| B | ASN218 | |
| B | HIS416 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:37994783, ECO:0007744|PDB:8Q1X |
| Chain | Residue | Details |
| A | PHE438 | |
| B | PHE438 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | SITE: Cleavage; by lysosomal cysteine proteases => ECO:0000305|PubMed:29386126, ECO:0000305|PubMed:37994783 |
| Chain | Residue | Details |
| A | ASN71 | |
| B | ASN71 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:37994783 |
| Chain | Residue | Details |
| A | ASN97 | |
| A | ASN132 | |
| B | ASN97 | |
| B | ASN132 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:37994783 |
| Chain | Residue | Details |
| A | ASN236 | |
| A | ASN284 | |
| A | ASN387 | |
| B | ASN236 | |
| B | ASN284 | |
| B | ASN387 |
