1WKS
 
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5VL1
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5BMU
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3UFG
 | | The crystal structure of glycyl-tRNA synthetase subunit alpha from Campylobacter jejuni subsp. jejuni NCTC in complex with ATP | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Glycyl-tRNA synthetase alpha subunit, LEUCINE | | Authors: | Tan, K, Zhou, M, Peterson, S, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | | Deposit date: | 2011-11-01 | | Release date: | 2011-11-09 | | Last modified: | 2024-11-27 | | Method: | X-RAY DIFFRACTION (2.552 Å) | | Cite: | The crystal structure of glycyl-tRNA synthetase subunit alpha from Campylobacter jejuni subsp. jejuni NCTC in complex with ATP
To be Published
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4LZZ
 | | Nucleotide-induced asymmetry within atpase activator ring drives s54-RNAP interaction and ATP hydrolysis | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Transcriptional regulator (NtrC family), ... | | Authors: | Sysoeva, T.A, Chowdhury, S, Guo, L, Nixon, B.T. | | Deposit date: | 2013-08-01 | | Release date: | 2013-12-04 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (3.21 Å) | | Cite: | Nucleotide-induced asymmetry within ATPase activator ring drives sigma 54-RNAP interaction and ATP hydrolysis.
Genes Dev., 27, 2013
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3SZ3
 | | Crystal structure of Tryptophanyl-tRNA synthetase from Vibrio cholerae with an endogenous tryptophan | | Descriptor: | GLYCEROL, TRYPTOPHAN, Tryptophanyl-tRNA synthetase | | Authors: | Cooper, D.R, Kudritska, M, Chruszcz, M, Savchenko, A, Anderson, W.F, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID) | | Deposit date: | 2011-07-18 | | Release date: | 2011-09-14 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Crystal structure of Tryptophanyl-tRNA synthetase from Vibrio cholerae with an endogenous tryptophan
To be Published
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4LY6
 | | Nucleotide-induced asymmetry within ATPase activator ring drives s54-RNAP interaction and ATP hydrolysis | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Transcriptional regulator (NtrC family), ... | | Authors: | Sysoeva, T.A, Chowdhury, S, Guo, L, Nixon, B.T. | | Deposit date: | 2013-07-30 | | Release date: | 2013-12-04 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (3.6 Å) | | Cite: | Nucleotide-induced asymmetry within ATPase activator ring drives sigma 54-RNAP interaction and ATP hydrolysis.
Genes Dev., 27, 2013
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2EL9
 | | Crystal structure of E.coli Histidyl-tRNA synthetase complexed with a histidyl-adenylate analogue | | Descriptor: | 5'-O-[(L-HISTIDYLAMINO)SULFONYL]ADENOSINE, Histidyl-tRNA synthetase | | Authors: | Yanagisawa, T, Si, S.Y, Matsuno, M, Ishii, R, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-03-27 | | Release date: | 2008-03-18 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Crystal structure of E.coli Histidyl-tRNA synthetase complexed with a histidyl-adenylate analogue
To be published
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1RAW
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2GI3
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8WIJ
 | | Crystal structure of E. coli ThrS catalytic domain mutant L489M in complex with Obafluorin | | Descriptor: | N-(2,3-dihydroxybenzoyl)-4-(4-nitrophenyl)-L-threonine, Threonine--tRNA ligase, ZINC ION | | Authors: | Qiao, H, Wang, Z, Wang, J, Fang, P. | | Deposit date: | 2023-09-24 | | Release date: | 2024-07-24 | | Last modified: | 2025-04-09 | | Method: | X-RAY DIFFRACTION (3.08 Å) | | Cite: | Specific glycine-dependent enzyme motion determines the potency of conformation selective inhibitors of threonyl-tRNA synthetase.
Commun Biol, 7, 2024
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8WIH
 | | Crystal structure of E. coli ThrS catalytic domain mutant G463A in complex with ATP | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Threonine--tRNA ligase, ZINC ION | | Authors: | Qiao, H, Wang, Z, Wang, J, Fang, P. | | Deposit date: | 2023-09-24 | | Release date: | 2024-07-24 | | Last modified: | 2025-04-09 | | Method: | X-RAY DIFFRACTION (2.44 Å) | | Cite: | Specific glycine-dependent enzyme motion determines the potency of conformation selective inhibitors of threonyl-tRNA synthetase.
Commun Biol, 7, 2024
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7F96
 | | Plasmodium falciparum Prolyl-tRNA Synthetase (PfPRS) in Complex with L-proline and compound L95 | | Descriptor: | PROLINE, Proline--tRNA ligase, ~{N}-[4-[(3~{S})-3-cyano-3-cyclopropyl-2-oxidanylidene-pyrrolidin-1-yl]-6-methyl-pyridin-2-yl]-2-phenyl-ethanamide | | Authors: | Mishra, S, Malhotra, N, Yogavel, M, Sharma, A. | | Deposit date: | 2021-07-04 | | Release date: | 2023-01-04 | | Last modified: | 2024-07-31 | | Method: | X-RAY DIFFRACTION (2.577 Å) | | Cite: | ATP mimetics targeting prolyl-tRNA synthetases as a new avenue for antimalarial drug development
Iscience, 27, 2024
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7F97
 | | Plasmodium falciparum Prolyl-tRNA Synthetase (PfPRS) in Complex with L-proline and compound L97 | | Descriptor: | 1,4-BUTANEDIOL, 4-[(3S)-3-cyclopropyl-3-(hydroxymethyl)-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(1-methylpyrazol-4-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, CHLORIDE ION, ... | | Authors: | Mishra, S, Malhotra, N, Yogavel, M, Sharma, A. | | Deposit date: | 2021-07-04 | | Release date: | 2023-01-04 | | Last modified: | 2024-07-31 | | Method: | X-RAY DIFFRACTION (2.394 Å) | | Cite: | ATP mimetics targeting prolyl-tRNA synthetases as a new avenue for antimalarial drug development
Iscience, 27, 2024
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3LSQ
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8YP1
 | | Crystal structure of HARS WHEP domain fused with Fc | | Descriptor: | Immunoglobulin heavy constant gamma 1,Histidine--tRNA ligase, cytoplasmic | | Authors: | Geng, Y, Zhai, L. | | Deposit date: | 2024-03-15 | | Release date: | 2025-02-12 | | Last modified: | 2025-04-02 | | Method: | X-RAY DIFFRACTION (2.79 Å) | | Cite: | A human histidyl-tRNA synthetase splice variant therapeutic targets NRP2 to resolve lung inflammation and fibrosis.
Sci Transl Med, 17, 2025
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8YTK
 | | Crystal structure of human prolyl-tRNA synthetase in complex with inhibitor | | Descriptor: | (2~{S})-~{N}-[3-(4-azanylquinazolin-7-yl)phenyl]sulfonylpyrrolidine-2-carboxamide, 1,2-ETHANEDIOL, Bifunctional glutamate/proline--tRNA ligase | | Authors: | Luo, Z, Zhou, H. | | Deposit date: | 2024-03-26 | | Release date: | 2025-04-02 | | Method: | X-RAY DIFFRACTION (2.553 Å) | | Cite: | Development of Potent Inhibitors Against Bacterial Prolyl-tRNA Synthetase Using Fluorine Scanning
To Be Published
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2Y95
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3M4P
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3NET
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3QO7
 | | Crystal structure of the seryl-tRNA synthetase from Candida albicans | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Seryl-tRNA synthetase, cytoplasmic | | Authors: | Rocha, R, Santos, M.A, Pereira, P.J.B, Macedo-Ribeiro, S. | | Deposit date: | 2011-02-09 | | Release date: | 2011-08-03 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Unveiling the structural basis for translational ambiguity tolerance in a human fungal pathogen.
Proc.Natl.Acad.Sci.USA, 108, 2011
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3QO8
 | | Crystal Structure of seryl-tRNA synthetase from Candida albicans | | Descriptor: | 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, MAGNESIUM ION, Seryl-tRNA synthetase, ... | | Authors: | Rocha, R, Santos, M.A, Pereira, P.J.B, Macedo-Ribeiro, S. | | Deposit date: | 2011-02-09 | | Release date: | 2011-08-03 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Unveiling the structural basis for translational ambiguity tolerance in a human fungal pathogen.
Proc.Natl.Acad.Sci.USA, 108, 2011
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2M21
 | | Solution structure of the Tetrahymena telomerase RNA stem IV terminal loop | | Descriptor: | 5'-R(*GP*GP*CP*GP*AP*UP*AP*CP*AP*CP*UP*AP*UP*UP*UP*AP*UP*CP*GP*CP*C)-3' | | Authors: | Cash, D.D, Richards, R.J, Wu, H, Trantirek, L, O'Connor, C.M, Feigon, J, Collins, K. | | Deposit date: | 2012-12-11 | | Release date: | 2013-03-20 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Structural study of elements of Tetrahymena telomerase RNA stem-loop IV domain important for function.
Rna, 12, 2006
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3PZ0
 | | The crystal structure of AaLeuRS-CP1 | | Descriptor: | CALCIUM ION, Leucyl-tRNA synthetase subunit alpha | | Authors: | Liu, R.J, Wang, E.D. | | Deposit date: | 2010-12-13 | | Release date: | 2011-08-24 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Peripheral insertion modulates the editing activity of the isolated CP1 domain of leucyl-tRNA synthetase
Biochem.J., 440, 2011
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3RF1
 | | The crystal structure of glycyl-tRNA synthetase subunit alpha from Campylobacter jejuni subsp. jejuni NCTC 11168 | | Descriptor: | (2S)-2-hydroxybutanedioic acid, GLYCEROL, Glycyl-tRNA synthetase alpha subunit | | Authors: | Tan, K, Zhang, R, Zhou, M, Hasseman, J, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | | Deposit date: | 2011-04-05 | | Release date: | 2011-04-20 | | Last modified: | 2024-11-27 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | The crystal structure of glycyl-tRNA synthetase subunit alpha from Campylobacter jejuni subsp. jejuni NCTC 11168
To be Published
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