7F96

Plasmodium falciparum Prolyl-tRNA Synthetase (PfPRS) in Complex with L-proline and compound L95

Summary for 7F96

Entry DOI	10.2210/pdb7f96/pdb
Descriptor	Proline--tRNA ligase, ~{N}-[4-[(3~{S})-3-cyano-3-cyclopropyl-2-oxidanylidene-pyrrolidin-1-yl]-6-methyl-pyridin-2-yl]-2-phenyl-ethanamide, PROLINE, ... (4 entities in total)
Functional Keywords	protein translation, malaria, inhibitor, prs, ligase
Biological source	Plasmodium falciparum 3D7
Total number of polymer chains	1
Total formula weight	58290.75
Authors	Mishra, S.,Malhotra, N.,Yogavel, M.,Sharma, A. (deposition date: 2021-07-04, release date: 2023-01-04, Last modification date: 2024-07-31)
Primary citation	Mishra, S.,Malhotra, N.,Laleu, B.,Chakraborti, S.,Yogavel, M.,Sharma, A. ATP mimetics targeting prolyl-tRNA synthetases as a new avenue for antimalarial drug development Iscience, 27:-, 2024 Cited by DOI: 10.1016/j.isci.2024.110049 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.577 Å)

Structure validation