3JAM
 
 | | CryoEM structure of 40S-eIF1A-eIF1 complex from yeast | | Descriptor: | 18S rRNA, MAGNESIUM ION, RACK1, ... | | Authors: | Llacer, J.L, Hussain, T, Ramakrishnan, V. | | Deposit date: | 2015-06-17 | | Release date: | 2015-08-12 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (3.46 Å) | | Cite: | Conformational Differences between Open and Closed States of the Eukaryotic Translation Initiation Complex.
Mol.Cell, 59, 2015
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6JNX
 | | Cryo-EM structure of a Q-engaged arrested complex | | Descriptor: | Antiterminator Q protein, DNA (63-MER), DNA-directed RNA polymerase subunit alpha, ... | | Authors: | Feng, Y, Shi, J. | | Deposit date: | 2019-03-18 | | Release date: | 2019-06-12 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (4.08 Å) | | Cite: | Structural basis of Q-dependent transcription antitermination.
Nat Commun, 10, 2019
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5FMQ
 | | Crystal structure of the mid, cap-binding, mid-link and 627 domains from avian influenza A virus polymerase PB2 subunit bound to M7GTP H32 crystal form | | Descriptor: | 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, INFLUENZA A PB2 SUBUNIT | | Authors: | Thierry, E, Pflug, A, Hart, D, Cusack, S. | | Deposit date: | 2015-11-07 | | Release date: | 2016-01-13 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of Pb2 Domains.
Mol.Cell, 61, 2016
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6J9F
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6J9E
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7ENA
 | | TFIID-based PIC-Mediator holo-complex in pre-assembled state (pre-hPIC-MED) | | Descriptor: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | | Authors: | Chen, X, Qi, Y, Wang, X, Wu, Z, Yin, X, Li, J, Liu, W, Xu, Y. | | Deposit date: | 2021-04-16 | | Release date: | 2021-05-26 | | Last modified: | 2021-06-16 | | Method: | ELECTRON MICROSCOPY (4.07 Å) | | Cite: | Structures of the human Mediator and Mediator-bound preinitiation complex.
Science, 372, 2021
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7ENC
 | | TFIID-based PIC-Mediator holo-complex in fully-assembled state (hPIC-MED) | | Descriptor: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | | Authors: | Chen, X, Qi, Y, Wang, X, Wu, Z, Yin, X, Li, J, Liu, W, Xu, Y. | | Deposit date: | 2021-04-16 | | Release date: | 2021-05-26 | | Last modified: | 2021-06-16 | | Method: | ELECTRON MICROSCOPY (4.13 Å) | | Cite: | Structures of the human Mediator and Mediator-bound preinitiation complex.
Science, 372, 2021
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6RIC
 | | Structure of the core Vaccinia Virus DNA-dependent RNA polymerase complex | | Descriptor: | DNA-dependent RNA polymerase subunit rpo132, DNA-dependent RNA polymerase subunit rpo147, DNA-dependent RNA polymerase subunit rpo18, ... | | Authors: | Grimm, C, Hillen, H.S, Bedenk, K, Bartuli, J, Neyer, S, Zhang, Q, Huettenhofer, A, Erlacher, M, Dienemann, C, Schlosser, A, Urlaub, H, Boettcher, B, Szalay, A, Cramer, P, Fischer, U. | | Deposit date: | 2019-04-23 | | Release date: | 2019-12-18 | | Last modified: | 2019-12-25 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Structural Basis of Poxvirus Transcription: Transcribing and Capping Vaccinia Complexes.
Cell, 179, 2019
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6N4C
 | | EM structure of the DNA wrapping in bacterial open transcription initiation complex | | Descriptor: | DNA (94-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | | Authors: | Florez-Ariza, A, Cassago, A, de Oliveira, P.S.L, Guerra, D.G, Portugal, R.V. | | Deposit date: | 2018-11-19 | | Release date: | 2020-05-27 | | Method: | ELECTRON MICROSCOPY (17 Å) | | Cite: | Interactions of Upstream and Downstream Promoter Regions with RNA Polymerase are Energetically Coupled and a Target of Regulation in Transcription Initiation
Biorxiv, 2020
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2DVI
 | | Complex structure of CCA-adding enzyme, mini-DCC and CTP | | Descriptor: | CCA-adding enzyme, CYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Tomita, K, Ishitani, R, Fukai, S, Nureki, O. | | Deposit date: | 2006-07-31 | | Release date: | 2006-11-14 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.61 Å) | | Cite: | Complete crystallographic analysis of the dynamics of CCA sequence addition
Nature, 443, 2006
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3RV1
 | | Crystal structure of the N-terminal and RNase III domains of K. polysporus Dcr1 E224Q mutant | | Descriptor: | K. polysporus Dcr1 | | Authors: | Nakanishi, K, Weinberg, D.E, Bartel, D.P, Patel, D.J. | | Deposit date: | 2011-05-05 | | Release date: | 2011-08-03 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.975 Å) | | Cite: | The inside-out mechanism of dicers from budding yeasts.
Cell(Cambridge,Mass.), 146, 2011
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6XH8
 | | CueR-transcription activation complex with RNA transcript | | Descriptor: | COPPER (II) ION, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | | Authors: | Liu, B, Shi, W, Yang, Y. | | Deposit date: | 2020-06-18 | | Release date: | 2021-04-14 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Structural basis of copper-efflux-regulator-dependent transcription activation.
Iscience, 24, 2021
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4YLP
 | | E. coli Transcription Initiation Complex - 16-bp spacer and 5-nt RNA | | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | Authors: | Zuo, Y, Steitz, T.A. | | Deposit date: | 2015-03-05 | | Release date: | 2015-04-22 | | Last modified: | 2019-12-25 | | Method: | X-RAY DIFFRACTION (5.5 Å) | | Cite: | Crystal Structures of the E. coli Transcription Initiation Complexes with a Complete Bubble.
Mol.Cell, 58, 2015
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3O2Q
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4YLO
 | | E. coli Transcription Initiation Complex - 16-bp spacer and 4-nt RNA | | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | Authors: | Zuo, Y, Steitz, T.A. | | Deposit date: | 2015-03-05 | | Release date: | 2015-04-22 | | Last modified: | 2019-12-25 | | Method: | X-RAY DIFFRACTION (6 Å) | | Cite: | Crystal Structures of the E. coli Transcription Initiation Complexes with a Complete Bubble.
Mol.Cell, 58, 2015
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7QXI
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4YLN
 | | E. coli Transcription Initiation Complex - 17-bp spacer and 4-nt RNA | | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | Authors: | Zuo, Y, Steitz, T.A. | | Deposit date: | 2015-03-05 | | Release date: | 2015-04-22 | | Last modified: | 2019-12-25 | | Method: | X-RAY DIFFRACTION (5.5 Å) | | Cite: | Crystal Structures of the E. coli Transcription Initiation Complexes with a Complete Bubble.
Mol.Cell, 58, 2015
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7RWI
 | | Mycobacterium tuberculosis RNA polymerase sigma L holoenzyme open promoter complex containing TNP-2198 | | Descriptor: | (3aM,9S,10bP,14S,15R,16S,17R,18R,19R,20S,21S,25R)-6,18,20-trihydroxy-14-methoxy-7,9,15,17,19,21,25-heptamethyl-1'-[2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl]-5,10,26-trioxo-3,5,9,10-tetrahydrospiro[9,4-(epoxypentadecanoimino)furo[2',3':7,8]naphtho[1,2-d]imidazole-2,4'-piperidin]-16-yl acetate, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | | Authors: | Molodtsov, V, Ebright, R.H. | | Deposit date: | 2021-08-19 | | Release date: | 2022-03-02 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (3.7 Å) | | Cite: | Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens.
J.Med.Chem., 65, 2022
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6X91
 | | Crystal structure of MBP-fused human APOBEC1 | | Descriptor: | CACODYLATE ION, Maltodextrin-binding protein, C->U-editing enzyme APOBEC-1 chimera, ... | | Authors: | Wolfe, A.D, Li, S.-X, Chen, X.S. | | Deposit date: | 2020-06-02 | | Release date: | 2020-12-09 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (3.51 Å) | | Cite: | The structure of APOBEC1 and insights into its RNA and DNA substrate selectivity.
NAR Cancer, 2, 2020
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1HD0
 | | HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN D0 (HNRNP D0 RBD1), NMR | | Descriptor: | PROTEIN (HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN D0) | | Authors: | Nagata, T, Kurihara, Y, Matsuda, G, Saeki, J, Kohno, T, Yanagida, Y, Ishikawa, F, Uesugi, S, Katahira, M. | | Deposit date: | 1999-05-18 | | Release date: | 2000-05-18 | | Last modified: | 2023-12-27 | | Method: | SOLUTION NMR | | Cite: | Structure and interactions with RNA of the N-terminal UUAG-specific RNA-binding domain of hnRNP D0.
J.Mol.Biol., 287, 1999
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1HD1
 | | HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN D0 (HNRNP D0 RBD1), NMR | | Descriptor: | PROTEIN (HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN D0) | | Authors: | Nagata, T, Kurihara, Y, Matsuda, G, Saeki, J, Kohno, T, Yanagida, Y, Ishikawa, F, Uesugi, S, Katahira, M. | | Deposit date: | 1999-05-18 | | Release date: | 2000-05-18 | | Last modified: | 2023-12-27 | | Method: | SOLUTION NMR | | Cite: | Structure and interactions with RNA of the N-terminal UUAG-specific RNA-binding domain of hnRNP D0.
J.Mol.Biol., 287, 1999
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5ZIT
 | | Crystal structure of human Enterovirus D68 RdRp in complex with NADPH | | Descriptor: | DI(HYDROXYETHYL)ETHER, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, RdRp | | Authors: | Wang, M.L, Li, L, Chen, Y.P, Jiang, H, Zhang, Y, Su, D. | | Deposit date: | 2018-03-17 | | Release date: | 2019-04-17 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (3.196 Å) | | Cite: | Structure of the enterovirus D68 RNA-dependent RNA polymerase in complex with NADPH implicates an inhibitor binding site in the RNA template tunnel.
J.Struct.Biol., 2020
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6LDI
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8U2B
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7UML
 | | Structure of vesicular stomatitis virus (local reconstruction, 3.5 A resolution) | | Descriptor: | Matrix protein, Nucleoprotein, RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') | | Authors: | Jenni, S, Horwitz, J.A, Bloyet, L.-M, Whelan, S.P.J, Harrison, S.C. | | Deposit date: | 2022-04-07 | | Release date: | 2022-04-20 | | Last modified: | 2024-02-14 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Visualizing molecular interactions that determine assembly of a bullet-shaped vesicular stomatitis virus particle.
Nat Commun, 13, 2022
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