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Crystallographic studies on N-azido-beta-D-glucopyranosylamine, an inhibitor of glycogen phosphorylase: comparison with N-acetyl-beta-D-glucopyranosylamine
Descriptor:	Glycogen phosphorylase, muscle form, N-(azidoacetyl)-beta-D-glucopyranosylamine, ...
Authors:	Petsalakis, E.I, Chrysina, E.D, Tiraidis, C, Hadjiloi, T, Leonidas, D.D, Oikonomakos, N.G, Aich, U, Varghese, B, Loganathan, D.
Deposit date:	2005-12-20
Release date:	2006-06-20
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (2.03 Å)
Cite:	Crystallographic studies on N-azidoacetyl-beta-d-glucopyranosylamine, an inhibitor of glycogen phosphorylase: Comparison with N-acetyl-beta-d-glucopyranosylamine. Bioorg.Med.Chem., 14, 2006

1UZU

Glycogen Phosphorylase b in complex with indirubin-5'-sulphonate
Descriptor:	2',3-DIOXO-1,1',2',3-TETRAHYDRO-2,3'-BIINDOLE-5'-SULFONIC ACID, GLYCOGEN PHOSPHORYLASE, MUSCLE FORM, ...
Authors:	Kosmopoulou, M.N, Leonidas, D.D, Chrysina, E.D, Bischler, N, Eisenbrand, G, Sakarellos, C.E, Pauptit, R, Oikonomakos, N.G.
Deposit date:	2004-03-16
Release date:	2004-05-27
Last modified:	2023-12-13
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Binding of the potential antitumour agent indirubin-5-sulphonate at the inhibitor site of rabbit muscle glycogen phosphorylase b. Comparison with ligand binding to pCDK2-cyclin A complex. Eur. J. Biochem., 271, 2004

2F3S

Crystal Structure of the glycogen phosphorylase B / ethyl-N-(beta-D-glucopyranosyl)oxamate complex
Descriptor:	Glycogen phosphorylase, muscle form, N-[ethoxy(oxo)acetyl]-beta-D-glucopyranosylamine, ...
Authors:	Oikonomakos, N.G, Leonidas, D.D.
Deposit date:	2005-11-22
Release date:	2006-05-09
Last modified:	2023-08-23
Method:	X-RAY DIFFRACTION (1.96 Å)
Cite:	Binding of oxalyl derivatives of beta-d-glucopyranosylamine to muscle glycogen phosphorylase b. Bioorg.Med.Chem., 14, 2006

2F3U

Crystal Structure of the glycogen phosphorylase B / N-(beta-D-glucopyranosyl)-N'-cyclopropyl oxalamide complex
Descriptor:	Glycogen phosphorylase, muscle form, N-[(cyclopropylamino)(oxo)acetyl]-beta-D-glucopyranosylamine, ...
Authors:	Oikonomakos, N.G, Leonidas, D.D.
Deposit date:	2005-11-22
Release date:	2006-05-09
Last modified:	2023-08-23
Method:	X-RAY DIFFRACTION (1.93 Å)
Cite:	Binding of oxalyl derivatives of beta-d-glucopyranosylamine to muscle glycogen phosphorylase b. Bioorg.Med.Chem., 14, 2006

2F3P

Crystal Structure of the glycogen phosphorylase B / N-(beta-D-glucopyranosyl)oxamic acid complex
Descriptor:	Glycogen phosphorylase, muscle form, N-(carboxycarbonyl)-beta-D-glucopyranosylamine, ...
Authors:	Oikonomakos, N.G, Leonidas, D.D.
Deposit date:	2005-11-22
Release date:	2006-05-09
Last modified:	2023-08-23
Method:	X-RAY DIFFRACTION (1.94 Å)
Cite:	Binding of oxalyl derivatives of beta-d-glucopyranosylamine to muscle glycogen phosphorylase b. Bioorg.Med.Chem., 14, 2006

2F3Q

Crystal structure of the glycogen phosphorylase B / methyl-N-(beta-D-glucopyranosyl)oxamate complex
Descriptor:	Glycogen phosphorylase, muscle form, N-[methoxy(oxo)acetyl]-beta-D-glucopyranosylamine, ...
Authors:	Oikonomakos, N.G, Leonidas, D.D.
Deposit date:	2005-11-22
Release date:	2006-05-09
Last modified:	2023-08-23
Method:	X-RAY DIFFRACTION (1.96 Å)
Cite:	Binding of oxalyl derivatives of beta-d-glucopyranosylamine to muscle glycogen phosphorylase b. Bioorg.Med.Chem., 14, 2006

3CEJ

Human glycogen phosphorylase (tense state) in complex with the allosteric inhibitor AVE2865
Descriptor:	1-{2-[3-(2-Chloro-4,5-difluoro-benzoyl)-ureido]-4-fluoro-phenyl}-piperidine-4-carboxylic acid, Glycogen phosphorylase, liver form, ...
Authors:	Wendt, K.U, Dreyer, M.K, Anderka, O, Klabunde, T, Loenze, P, Defossa, E, Schmoll, D.
Deposit date:	2008-02-29
Release date:	2008-05-27
Last modified:	2020-07-29
Method:	X-RAY DIFFRACTION (3.3 Å)
Cite:	Thermodynamic characterization of allosteric glycogen phosphorylase inhibitors. Biochemistry, 47, 2008

1WW2

Crystallographic studies on two bioisosteric analogues, N-acetyl-beta-D-glucopyranosylamine and N-trifluoroacetyl-beta-D-glucopyranosylamine, potent inhibitors of muscle glycogen phosphorylase
Descriptor:	Glycogen phosphorylase, muscle form, N-acetyl-beta-D-glucopyranosylamine, ...
Authors:	Anagnostou, E, Kosmopoulou, M.N, Chrysina, E.D, Leonidas, D.D, Hadjiloi, T, Tiraidis, C, Zographos, S.E, Gyorgydeak, Z, Somsak, L, Docsa, T, Gergely, P, Kolisis, F.N, Oikonomakos, N.G.
Deposit date:	2004-12-30
Release date:	2005-12-13
Last modified:	2023-10-25
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Crystallographic studies on two bioisosteric analogues, N-acetyl-beta-d-glucopyranosylamine and N-trifluoroacetyl-beta-d-glucopyranosylamine, potent inhibitors of muscle glycogen phosphorylase Bioorg.Med.Chem., 14, 2006

1FTW

STRUCTURES OF GLYCOGEN PHOSPHORYLASE-INHIBITOR COMPLEXES AND THE IMPLICATIONS FOR STRUCTURE-BASED DRUG DESIGN
Descriptor:	(5S,7R,8S,9S,10R)-3,8,9,10-tetrahydroxy-7-(hydroxymethyl)-6-oxa-1,3-diazaspiro[4.5]decane-2,4-dione, GLYCOGEN PHOSPHORYLASE, PYRIDOXAL-5'-PHOSPHATE
Authors:	Watson, K.A, Tsitsanou, K.E, Gregoriou, M, Zographos, S.E, Skamnaki, V.T, Oikonomakos, N.G, Fleet, G.W, Johnson, L.N.
Deposit date:	2000-09-13
Release date:	2000-10-04
Last modified:	2023-08-09
Method:	X-RAY DIFFRACTION (2.36 Å)
Cite:	Kinetic and crystallographic studies of glucopyranose spirohydantoin and glucopyranosylamine analogs inhibitors of glycogen phosphorylase. Proteins, 61, 2005

1FTQ

STRUCTURES OF GLYCOGEN PHOSPHORYLASE-INHIBITOR COMPLEXES AND THE IMPLICATIONS FOR STRUCTURE-BASED DRUG DESIGN
Descriptor:	(5S,7R,8S,9S,10R)-3-amino-8,9,10-trihydroxy-7-(hydroxymethyl)-6-oxa-1,3-diazaspiro[4.5]decane-2,4-dione, GLYCOGEN PHOSPHORYLASE, INOSINIC ACID, ...
Authors:	Watson, K.A, Tsitsanou, K.E, Gregoriou, M, Zographos, S.E, Skamnaki, V.T, Oikonomakos, N.G, Fleet, G.W, Johnson, L.N.
Deposit date:	2000-09-13
Release date:	2000-10-04
Last modified:	2023-08-09
Method:	X-RAY DIFFRACTION (2.35 Å)
Cite:	Kinetic and crystallographic studies of glucopyranose spirohydantoin and glucopyranosylamine analogs inhibitors of glycogen phosphorylase. Proteins, 61, 2005

1FS4

Structures of glycogen phosphorylase-inhibitor complexes and the implications for structure-based drug design
Descriptor:	1-DEOXY-1-METHOXYCARBAMIDO-BETA-D-GLUCO-2-HEPTULOPYRANOSONAMIDE, GLYCOGEN PHOSPHORYLASE, PYRIDOXAL-5'-PHOSPHATE
Authors:	Watson, K.A, Tsitsanou, K.E, Gregoriou, M, Zographos, S.E, Skamnaki, V.T, Oikonomakos, N.G, Fleet, G.W, Johnson, L.N.
Deposit date:	2000-09-08
Release date:	2000-10-04
Last modified:	2020-07-29
Method:	X-RAY DIFFRACTION (2.38 Å)
Cite:	Kinetic and crystallographic studies of glucopyranose spirohydantoin and glucopyranosylamine analogs inhibitors of glycogen phosphorylase. Proteins, 61, 2005

1FU8

STRUCTURES OF GLYCOGEN PHOSPHORYLASE-INHIBITOR COMPLEXES AND THE IMPLICATIONS FOR STRUCTURE-BASED DRUG DESIGN
Descriptor:	1-DEOXY-1-ACETYLAMINO-BETA-D-GLUCO-2-HEPTULOPYRANOSONAMIDE, GLYCOGEN PHOSPHORYLASE, PYRIDOXAL-5'-PHOSPHATE
Authors:	Watson, K.A, Tsitsanou, K.E, Gregoriou, M, Zographos, S.E, Skamnaki, V.T, Oikonomakos, N.G, Fleet, G.W, Johnson, L.N.
Deposit date:	2000-09-14
Release date:	2000-10-04
Last modified:	2023-08-09
Method:	X-RAY DIFFRACTION (2.35 Å)
Cite:	Kinetic and crystallographic studies of glucopyranose spirohydantoin and glucopyranosylamine analogs inhibitors of glycogen phosphorylase. Proteins, 61, 2005

1FTY

STRUCTURES OF GLYCOGEN PHOSPHORYLASE-INHIBITOR COMPLEXES AND THE IMPLICATIONS FOR STRUCTURE-BASED DRUG DESIGN
Descriptor:	8,9,10-TRIHYDROXY-7-HYDROXYMETHYL-3-METHYL-6-OXA-1,3-DIAZA-SPIRO[4.5]DECANE-2,4-DIONE, GLYCOGEN PHOSPHORYLASE, PYRIDOXAL-5'-PHOSPHATE
Authors:	Watson, K.A, Tsitsanou, K.E, Gregoriou, M, Zographos, S.E, Skamnaki, V.T, Oikonomakos, N.G, Fleet, G.W, Johnson, L.N.
Deposit date:	2000-09-13
Release date:	2000-10-04
Last modified:	2023-08-09
Method:	X-RAY DIFFRACTION (2.38 Å)
Cite:	Kinetic and crystallographic studies of glucopyranose spirohydantoin and glucopyranosylamine analogs inhibitors of glycogen phosphorylase. Proteins, 61, 2005

1K08

Crystallographic Binding Study of 10 mM N-benzoyl-N'-beta-D-glucopyranosyl urea to glycogen phosphorylase b
Descriptor:	Glycogen Phosphorylase, N-[(phenylcarbonyl)carbamoyl]-beta-D-glucopyranosylamine, PYRIDOXAL-5'-PHOSPHATE
Authors:	Oikonomakos, N.G, Kosmopoulou, M, Zographos, S.E, Leonidas, D.D, Chrysina, E.D, Somsak, L, Nagy, V, Praly, J.P, Docsa, T, Toth, B, Gergely, P.
Deposit date:	2001-09-18
Release date:	2001-10-03
Last modified:	2023-08-16
Method:	X-RAY DIFFRACTION (2.26 Å)
Cite:	Binding of N-acetyl-N '-beta-D-glucopyranosyl urea and N-benzoyl-N '-beta-D-glucopyranosyl urea to glycogen phosphorylase b: kinetic and crystallographic studies. Eur.J.Biochem., 269, 2002

1K06

Crystallographic Binding Study of 100 mM N-benzoyl-N'-beta-D-glucopyranosyl urea to glycogen phosphorylase b
Descriptor:	Glycogen Phosphorylase, N-[(phenylcarbonyl)carbamoyl]-beta-D-glucopyranosylamine, PYRIDOXAL-5'-PHOSPHATE
Authors:	Oikonomakos, N.G, Kosmopoulou, M, Zographos, S.E, Leonidas, D.D, Chrysina, E.D, Somsak, L, Nagy, V, Praly, J.P, Docsa, T, Toth, B, Gergely, P.
Deposit date:	2001-09-18
Release date:	2001-10-03
Last modified:	2023-08-16
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Binding of N-acetyl-N '-beta-D-glucopyranosyl urea and N-benzoyl-N '-beta-D-glucopyranosyl urea to glycogen phosphorylase b: kinetic and crystallographic studies. Eur.J.Biochem., 269, 2002

1KTI

BINDING OF 100 MM N-ACETYL-N'-BETA-D-GLUCOPYRANOSYL UREA TO GLYCOGEN PHOSPHORYLASE B: KINETIC AND CRYSTALLOGRAPHIC STUDIES
Descriptor:	GLYCOGEN PHOSPHORYLASE, MUSCLE FORM, N-(acetylcarbamoyl)-beta-D-glucopyranosylamine, ...
Authors:	Oikonomakos, N.G, Kosmopoulou, M, Zographos, S.E, Leonidas, D.D, Chrysina, E.D, Somsak, L, Nagy, V, Praly, J.P, Docsa, T, Toth, B, Gergely, P.
Deposit date:	2002-01-16
Release date:	2002-01-30
Last modified:	2020-07-29
Method:	X-RAY DIFFRACTION (1.97 Å)
Cite:	Binding of N-acetyl-N'-beta-D-glucopyranosyl urea and N-benzoyl-N'-beta-D-glucopyranosyl urea to glycogen phosphorylase b: kinetic and crystallographic studies. Eur.J.Biochem., 269, 2002

4CTO

Glucopyranosylidene-spiro-iminothiazolidinone, a New Bicyclic Ring System: Synthesis, Derivatization, and Evaluation as Glycogen Phosphorylase Inhibitors by Enzyme Kinetic and Crystallographic Methods
Descriptor:	GLYCOGEN PHOSPHORYLASE, MUSCLE FORM, N-[(2Z,5R,7R,8S,9S,10R)-8,9,10-trihydroxy-7-(hydroxymethyl)-4-oxo-6-oxa-1-thia-3-azaspiro[4.5]dec-2-ylidene]benzamide, ...
Authors:	Alexacou, K.M, Papakonstantinou, M, Leonidas, D.D, Zographos, S.E, Chrysina, E.D.
Deposit date:	2014-03-15
Release date:	2014-08-06
Last modified:	2023-12-20
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Glucopyranosylidene-Spiro-Iminothiazolidinone, a New Bicyclic Ring System: Synthesis, Derivatization, and Evaluation for Inhibition of Glycogen Phosphorylase by Enzyme Kinetic and Crystallographic Methods. Bioorg.Med.Chem., 22, 2014

1NOI

COMPLEX OF GLYCOGEN PHOSPHORYLASE WITH A TRANSITION STATE ANALOGUE NOJIRIMYCIN TETRAZOLE AND PHOSPHATE IN THE T AND R STATES
Descriptor:	GLYCOGEN PHOSPHORYLASE, NOJIRIMYCINE TETRAZOLE, PHOSPHATE ION, ...
Authors:	Johnson, L.N, Mitchell, E.P.
Deposit date:	1996-03-12
Release date:	1996-08-01
Last modified:	2024-06-05
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Ternary complex crystal structures of glycogen phosphorylase with the transition state analogue nojirimycin tetrazole and phosphate in the T and R states. Biochemistry, 35, 1996

3NP9

Glycogen phosphorylase complexed with 3-(beta-D-glucopyranosyl)-2-hydroxy-5-methoxy-chlorobenzene
Descriptor:	(1S)-1,5-anhydro-1-(3-chloro-2-hydroxy-5-methoxyphenyl)-D-glucitol, Glycogen phosphorylase, muscle form
Authors:	Alexacou, K.-M.
Deposit date:	2010-06-28
Release date:	2011-06-08
Last modified:	2023-11-22
Method:	X-RAY DIFFRACTION (1.999 Å)
Cite:	Halogen-substituted (C-beta-D-glucopyranosyl)-hydroquinone regioisomers: synthesis, enzymatic evaluation and their binding to glycogen phosphorylase. Bioorg.Med.Chem., 19, 2011

3NPA

Glycogen phosphorylase complexed with 2,5-dihydroxy-4-(beta-D-glucopyranosyl)-bromo-benzene
Descriptor:	(1S)-1,5-anhydro-1-(4-bromo-2,5-dihydroxyphenyl)-D-glucitol, Glycogen phosphorylase, muscle form
Authors:	Alexacou, K.-M.
Deposit date:	2010-06-28
Release date:	2011-06-08
Last modified:	2023-11-22
Method:	X-RAY DIFFRACTION (1.969 Å)
Cite:	Halogen-substituted (C-beta-D-glucopyranosyl)-hydroquinone regioisomers: synthesis, enzymatic evaluation and their binding to glycogen phosphorylase. Bioorg.Med.Chem., 19, 2011

3NP7

Glycogen phosphorylase complexed with 2,5-dihydroxy-3-(beta-D-glucopyranosyl)-chlorobenzene and 2,5-dihydroxy-4-(beta-D-glucopyranosyl)-chlorobenzene
Descriptor:	(1S)-1,5-anhydro-1-(3-chloro-2,5-dihydroxyphenyl)-D-glucitol, (1S)-1,5-anhydro-1-(4-chloro-2,5-dihydroxyphenyl)-D-glucitol, Glycogen phosphorylase, ...
Authors:	Alexacou, K.-M.
Deposit date:	2010-06-28
Release date:	2011-06-08
Last modified:	2023-11-22
Method:	X-RAY DIFFRACTION (2.05 Å)
Cite:	Halogen-substituted (C-beta-D-glucopyranosyl)-hydroquinone regioisomers: synthesis, enzymatic evaluation and their binding to glycogen phosphorylase. Bioorg.Med.Chem., 19, 2011

3T3I

Glycogen Phosphorylase b in complex with GlcCF3U
Descriptor:	1-(beta-D-glucopyranosyl)-5-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione, Glycogen phosphorylase, muscle form
Authors:	Kantsadi, A.L, Skamnaki, V.T, Leonidas, D.D.
Deposit date:	2011-07-25
Release date:	2012-02-15
Last modified:	2023-12-06
Method:	X-RAY DIFFRACTION (2.65 Å)
Cite:	The sigma-Hole Phenomenon of Halogen Atoms Forms the Structural Basis of the Strong Inhibitory Potency of C5 Halogen Substituted Glucopyranosyl Nucleosides towards Glycogen Phosphorylase b Chemmedchem, 7, 2012

3T3H

Glycogen Phosphorylase b in complex with GlcIU
Descriptor:	1-(beta-D-glucopyranosyl)-5-iodopyrimidine-2,4(1H,3H)-dione, Glycogen phosphorylase, muscle form
Authors:	Kantsadi, A.L, Skamnaki, V.T, Leonidas, D.D.
Deposit date:	2011-07-25
Release date:	2012-02-15
Last modified:	2023-12-06
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	The sigma-Hole Phenomenon of Halogen Atoms Forms the Structural Basis of the Strong Inhibitory Potency of C5 Halogen Substituted Glucopyranosyl Nucleosides towards Glycogen Phosphorylase b Chemmedchem, 7, 2012

3T3D

Glycogen phosphorylase b in complex with GlcU
Descriptor:	1-beta-D-glucopyranosylpyrimidine-2,4(1H,3H)-dione, Glycogen phosphorylase, muscle form
Authors:	Kantsadi, A.L, Skamnaki, V.T, Leonidas, D.D.
Deposit date:	2011-07-25
Release date:	2012-02-15
Last modified:	2023-12-06
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	The sigma-Hole Phenomenon of Halogen Atoms Forms the Structural Basis of the Strong Inhibitory Potency of C5 Halogen Substituted Glucopyranosyl Nucleosides towards Glycogen Phosphorylase b Chemmedchem, 7, 2012

3T3G

Glycogen Phosphorylase b in complex with GlcBrU
Descriptor:	5-bromo-1-(beta-D-glucopyranosyl)pyrimidine-2,4(1H,3H)-dione, Glycogen phosphorylase, muscle form
Authors:	Kantsadi, A.L, Skamnaki, V.T, Leonidas, D.D.
Deposit date:	2011-07-25
Release date:	2012-02-15
Last modified:	2023-12-06
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	The sigma-Hole Phenomenon of Halogen Atoms Forms the Structural Basis of the Strong Inhibitory Potency of C5 Halogen Substituted Glucopyranosyl Nucleosides towards Glycogen Phosphorylase b Chemmedchem, 7, 2012

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Total results:	367
Displayed results:	25
Sorted by:	Hit score (from highest)
Query:	glycogen phosphorylase