4CTO

Glucopyranosylidene-spiro-iminothiazolidinone, a New Bicyclic Ring System: Synthesis, Derivatization, and Evaluation as Glycogen Phosphorylase Inhibitors by Enzyme Kinetic and Crystallographic Methods

Summary for 4CTO

Entry DOI	10.2210/pdb4cto/pdb
Related	4CTM 4CTN
Descriptor	GLYCOGEN PHOSPHORYLASE, MUSCLE FORM, N-[(2Z,5R,7R,8S,9S,10R)-8,9,10-trihydroxy-7-(hydroxymethyl)-4-oxo-6-oxa-1-thia-3-azaspiro[4.5]dec-2-ylidene]benzamide, PYRIDOXAL-5'-PHOSPHATE, ... (5 entities in total)
Functional Keywords	transferase, type 2 diabetes, inhibitor, structure-based drug design
Biological source	ORYCTOLAGUS CUNICULUS (RABBIT)
Total number of polymer chains	1
Total formula weight	98132.87
Authors	Alexacou, K.M.,Papakonstantinou, M.,Leonidas, D.D.,Zographos, S.E.,Chrysina, E.D. (deposition date: 2014-03-15, release date: 2014-08-06, Last modification date: 2023-12-20)
Primary citation	Czifrak, K.,Deak, S.,Pahi, A.,Kover, K.E.,Docsa, T.,Gergely, P.,Alexacou, K.M.,Papakonstantinou, M.,Leonidas, D.D.,Zographos, S.E.,Chrysina, E.D.,Somsak, L. Glucopyranosylidene-Spiro-Iminothiazolidinone, a New Bicyclic Ring System: Synthesis, Derivatization, and Evaluation for Inhibition of Glycogen Phosphorylase by Enzyme Kinetic and Crystallographic Methods. Bioorg.Med.Chem., 22:4028-, 2014 Cited by PubMed: 25009003 DOI: 10.1016/J.BMC.2014.05.076 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation