3NPA

Glycogen phosphorylase complexed with 2,5-dihydroxy-4-(beta-D-glucopyranosyl)-bromo-benzene

Summary for 3NPA

Entry DOI	10.2210/pdb3npa/pdb
Related	3NP7 3NP9
Descriptor	Glycogen phosphorylase, muscle form, (1S)-1,5-anhydro-1-(4-bromo-2,5-dihydroxyphenyl)-D-glucitol (3 entities in total)
Functional Keywords	glycogenolysis, type 2 diabetes, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Oryctolagus cuniculus (European rabbit,Japanese white rabbit,domestic rabbit,rabbits)
Total number of polymer chains	1
Total formula weight	97870.47
Authors	Alexacou, K.-M. (deposition date: 2010-06-28, release date: 2011-06-08, Last modification date: 2023-11-22)
Primary citation	Alexacou, K.M.,Zhang, Y.Z.,Praly, J.P.,Zographos, S.E.,Chrysina, E.D.,Oikonomakos, N.G.,Leonidas, D.D. Halogen-substituted (C-beta-D-glucopyranosyl)-hydroquinone regioisomers: synthesis, enzymatic evaluation and their binding to glycogen phosphorylase. Bioorg.Med.Chem., 19:5125-5136, 2011 Cited by PubMed: 21821421 DOI: 10.1016/j.bmc.2011.07.024 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.969 Å)

Structure validation