1WW2

Crystallographic studies on two bioisosteric analogues, N-acetyl-beta-D-glucopyranosylamine and N-trifluoroacetyl-beta-D-glucopyranosylamine, potent inhibitors of muscle glycogen phosphorylase

Summary for 1WW2

Entry DOI	10.2210/pdb1ww2/pdb
Related	1WW3 2PRJ
Descriptor	Glycogen phosphorylase, muscle form, N-acetyl-beta-D-glucopyranosylamine, PYRIDOXAL-5'-PHOSPHATE, ... (4 entities in total)
Functional Keywords	glycogenolysis, type 2 diabetes, transferase
Biological source	Oryctolagus cuniculus (rabbit)
Total number of polymer chains	1
Total formula weight	97759.55
Authors	Anagnostou, E.,Kosmopoulou, M.N.,Chrysina, E.D.,Leonidas, D.D.,Hadjiloi, T.,Tiraidis, C.,Zographos, S.E.,Gyorgydeak, Z.,Somsak, L.,Docsa, T.,Gergely, P.,Kolisis, F.N.,Oikonomakos, N.G. (deposition date: 2004-12-30, release date: 2005-12-13, Last modification date: 2023-10-25)
Primary citation	Anagnostou, E.,Kosmopoulou, M.N.,Chrysina, E.D.,Leonidas, D.D.,Hadjiloi, T.,Tiraidis, C.,Zographos, S.E.,Gyorgydeak, Z.,Somsak, L.,Docsa, T.,Gergely, P.,Kolisis, F.N.,Oikonomakos, N.G. Crystallographic studies on two bioisosteric analogues, N-acetyl-beta-d-glucopyranosylamine and N-trifluoroacetyl-beta-d-glucopyranosylamine, potent inhibitors of muscle glycogen phosphorylase Bioorg.Med.Chem., 14:181-189, 2006 Cited by PubMed: 16213146 DOI: 10.1016/j.bmc.2005.08.010 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation