1WW2
Crystallographic studies on two bioisosteric analogues, N-acetyl-beta-D-glucopyranosylamine and N-trifluoroacetyl-beta-D-glucopyranosylamine, potent inhibitors of muscle glycogen phosphorylase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Glycogen phosphorylase, muscle form | polymer | 842 | 97291.2 | 1 | UniProt (P00489) Pfam (PF00343) | Oryctolagus cuniculus (rabbit) | Myophosphorylase |
| 2 | B (A) | N-acetyl-beta-D-glucopyranosylamine | non-polymer | 221.2 | 1 | Chemie (NBG) PubChem (18656113) PubChem (21308223) PubChem (151446) PubChem (40549451) PubChem (40549452) PubChem (445382) PubChem (44335486) PubChem (51415028) PubChem (51415029) PubChem (53907776) PubChem (3832189) PubChem (9815885) PubChem (13422336) PubChem (101259527) PubChem (10376202) PubChem (124385630) PubChem (124799500) PubChem (124799501) PubChem (129406184) PubChem (135075397) | |||
| 3 | C (A) | PYRIDOXAL-5'-PHOSPHATE | non-polymer | 247.1 | 1 | Chemie (PLP) PubChem (1051) | |||
| 4 | D (A) | water | water | 18.0 | 356 | Chemie (HOH) |
Sequence modifications
A: 1 - 842 (UniProt: P00489)
| PDB | External Database | Details |
|---|---|---|
| Ile 380 | Leu 380 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 97291.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 468.4 | |
| All* | Total formula weight | 97759.6 |
