PDB: 620 resultsInfo pagesStatus searchChemie searchBIRD

---

4Y5I	Crystal structure of C-terminal modified Tau peptide-hybrid 126B with 14-3-3sigma Descriptor: 14-3-3 protein sigma, CHLORIDE ION, Microtubule-associated protein tau Authors: Leysen, S, Bartel, M, Milroy, L, Brunsveld, L, Ottmann, C. Deposit date: 2015-02-11 Release date: 2016-01-13 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Stabilizer-Guided Inhibition of Protein-Protein Interactions. Angew.Chem.Int.Ed.Engl., 54, 2015
5WFU	Structural basis for the interaction of 14-3-3beta with Tricarboxylic Acid Cycle intermediate Malate Descriptor: 14-3-3 protein beta/alpha, D-MALATE Authors: Hou, Z.Q, Liu, X.Y. Deposit date: 2017-07-12 Release date: 2018-07-18 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.97 Å) Cite: Structural basis for the interaction of 14-3-3beta with Tricarboxylic Acid Cycle intermediate Malate To Be Published
4ZDR	Crystal structure of 14-3-3[zeta]-LKB1 fusion protein Descriptor: 14-3-3 protein zeta/delta,GGSGGS linker,Serine/threonine-protein kinase STK11, GLYCEROL, PROPANE, ... Authors: Ding, S, Shi, Z.B. Deposit date: 2015-04-18 Release date: 2015-09-09 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.899 Å) Cite: Structure of the 14-3-3 zeta-LKB1 fusion protein provides insight into a novel ligand-binding mode of 14-3-3. Acta Crystallogr.,Sect.F, 71, 2015
5OEH	Molecular tweezers modulate 14-3-3 protein-protein interactions. Descriptor: (1R,5S,9S,16R,20R,24S,28S,35R)-3,22-Bis(dihydroxyphosphoryloxy)tridecacyclo[22.14.1.15,20.19,16.128,35.02,23.04,21.06,19.08,17.010,15.025,38.027,36.029,34]dotetraconta-2(23),3,6,8(17),10,12,14,18,21,25,27(36),29,31,33,37-pentadecaene, 14-3-3 protein sigma, CHLORIDE ION, ... Authors: Bier, D, Ottmann, C. Deposit date: 2017-07-07 Release date: 2017-07-26 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Molecular tweezers modulate 14-3-3 protein-protein interactions. Nat Chem, 5, 2013
4FJ3	14-3-3 isoform zeta in complex with a diphoyphorylated C-RAF peptide Descriptor: 14-3-3 protein zeta/delta, RAF proto-oncogene serine/threonine-protein kinase Authors: Ottmann, C, Molzan, M. Deposit date: 2012-06-11 Release date: 2012-09-05 Last modified: 2013-07-10 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Synergistic binding of the phosphorylated S233- and S259-binding sites of C-RAF to one 14-3-3zeta dimer J.Mol.Biol., 423, 2012
5OKF	CH1 chimera of human 14-3-3 sigma with the HSPB6 phosphopeptide in a conformation with self-bound phosphopeptides Descriptor: 14-3-3 protein sigma,Heat shock protein beta-6, CADMIUM ION Authors: Sluchanko, N.N, Tugaeva, K.V, Greive, S.J, Antson, A.A. Deposit date: 2017-07-25 Release date: 2017-10-11 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Chimeric 14-3-3 proteins for unraveling interactions with intrinsically disordered partners. Sci Rep, 7, 2017
3MHR	14-3-3 sigma in complex with YAP pS127-peptide Descriptor: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... Authors: Schumacher, B, Skwarczynska, M, Rose, R, Ottmann, C. Deposit date: 2010-04-08 Release date: 2010-09-15 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.15 Å) Cite: Structure of a 14-3-3[sigma]-YAP phosphopeptide complex at 1.15 A resolution Acta Crystallogr.,Sect.F, 66, 2010
5BTV	Crystal structure of human 14-3-3 sigma in complex with a Tau-protein peptide surrounding pS324 Descriptor: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... Authors: Ottmann, C, Schumacher, B, Bartel, M. Deposit date: 2015-06-03 Release date: 2016-07-20 Last modified: 2019-03-13 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Involvement of 14-3-3 in tubulin instability and impaired axon development is mediated by Tau. Faseb J., 29, 2015
3UAL	Crystal Structure of 14-3-3 epsilon with Mlf1 peptide Descriptor: 14-3-3 protein epsilon, Myeloid leukemia factor 1, TERTIARY-BUTYL ALCOHOL Authors: Weyand, M, Ottmann, C. Deposit date: 2011-10-21 Release date: 2012-01-25 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural insights of the MLF1/14-3-3 interaction. Febs J., 279, 2012
4GNT	Complex of ChREBP and 14-3-3beta Descriptor: 14-3-3 protein beta/alpha, Carbohydrate-responsive element-binding protein, SULFATE ION Authors: Zhang, H, Huang, N. Deposit date: 2012-08-17 Release date: 2012-10-24 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.41 Å) Cite: Crystal Structure of Carbohydrate Response Element Binding Protein (ChREBP) in complex with 14-3-3b To be Published
6A5Q	Structure of 14-3-3 beta in complex with TFEB 14-3-3 binding motif Descriptor: 14-3-3 protein beta/alpha, MALONIC ACID, TFEB pS211-peptide Authors: Xu, Y, Ren, J.Q, Feng, W. Deposit date: 2018-06-25 Release date: 2019-02-13 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2 Å) Cite: YWHA/14-3-3 proteins recognize phosphorylated TFEB by a noncanonical mode for controlling TFEB cytoplasmic localization. Autophagy, 15, 2019
3U9X	Covalent attachment of pyridoxal-phosphate derivatives to 14-3-3 proteins Descriptor: 14-3-3 protein sigma, CHLORIDE ION, GLYCEROL, ... Authors: Thiel, P, Roeglin, L, Kohlbacher, O, Ottmann, C. Deposit date: 2011-10-20 Release date: 2012-05-09 Last modified: 2012-05-16 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Covalent attachment of pyridoxal-phosphate derivatives to 14-3-3 proteins. Proc.Natl.Acad.Sci.USA, 109, 2012
4HKC	14-3-3-zeta in complex with S1011 phosphorylated integrin alpha-4 peptide Descriptor: 14-3-3 protein zeta/delta, GLYCEROL, alpha-4 integrin derived phosphorylated peptide Authors: Bonet, R, Campbell, I.D. Deposit date: 2012-10-15 Release date: 2013-06-26 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Characterization of 14-3-3-zeta Interactions with integrin tails J.Mol.Biol., 425, 2013
8QT5	Crystal structure of Arabidopsis thaliana 14-3-3 isoform lambda in complex with a phosphopeptide from the transcription factor BZR1. Descriptor: 14-3-3-like protein G-BOX factor 14 lambda,Protein BRASSINAZOLE-RESISTANT 1, ACETATE ION Authors: Hothorn, M, Obergfell, E. Deposit date: 2023-10-12 Release date: 2023-10-25 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (2.69 Å) Cite: Mechanistic insights into the function of 14-3-3 proteins as negative regulators of brassinosteroid signaling in Arabidopsis. Plant Cell.Physiol., 2024
8QTC	Crystal structure of Arabidopsis thaliana 14-3-3 omega in complex with a phosphopeptide from the transcription factor BZR1. Descriptor: 14-3-3-like protein GF14 omega, COBALT (II) ION, Protein BRASSINAZOLE-RESISTANT 1, ... Authors: Hothorn, M, Obergfell, E. Deposit date: 2023-10-12 Release date: 2023-11-15 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Mechanistic insights into the function of 14-3-3 proteins as negative regulators of brassinosteroid signaling in Arabidopsis. Plant Cell.Physiol., 2024
8QTT	Crystal structure of a C-terminally truncated version of Arabidopsis thaliana 14-3-3 omega in complex with a phosphopeptide from the inhibitor protein BKI1. Descriptor: 1,2-ETHANEDIOL, 14-3-3-like protein GF14 omega, BRI1 kinase inhibitor 1, ... Authors: Hothorn, M, Obergfell, E. Deposit date: 2023-10-13 Release date: 2023-11-15 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Mechanistic insights into the function of 14-3-3 proteins as negative regulators of brassinosteroid signaling in Arabidopsis. Plant Cell.Physiol., 2024
8QTF	Crystal structure of a C-terminally truncated version of Arabidopsis thaliana 14-3-3 omega in complex with a phosphopeptide from the transcription factor BZR1. Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, 14-3-3-like protein GF14 omega, ... Authors: Hothorn, M, Obergfell, E. Deposit date: 2023-10-12 Release date: 2023-11-22 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Mechanistic insights into the function of 14-3-3 proteins as negative regulators of brassinosteroid signaling in Arabidopsis. Plant Cell.Physiol., 2024
8DGN	14-3-3 epsilon bound to phosphorylated PEAK2 (pS826) peptide Descriptor: 14-3-3 protein epsilon, Phosphorylated PEAK2 (pS826) peptide Authors: Roy, M.J, Hardy, J.M, Lucet, I.S. Deposit date: 2022-06-24 Release date: 2023-06-07 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (3.16 Å) Cite: Structural mapping of PEAK pseudokinase interactions identifies 14-3-3 as a molecular switch for PEAK3 signaling. Nat Commun, 14, 2023
8DGM	14-3-3 epsilon bound to phosphorylated PEAK1 (pT1165) peptide Descriptor: 1,2-ETHANEDIOL, 14-3-3 protein epsilon, Inactive tyrosine-protein kinase PEAK1 Authors: Roy, M.J, Hardy, J.M, Lucet, I.S. Deposit date: 2022-06-24 Release date: 2023-06-07 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Structural mapping of PEAK pseudokinase interactions identifies 14-3-3 as a molecular switch for PEAK3 signaling. Nat Commun, 14, 2023
8DGP	14-3-3 epsilon bound to phosphorylated PEAK3 (pS69) peptide Descriptor: 1,2-ETHANEDIOL, 14-3-3 protein epsilon, Phosphorylated PEAK3 (pS69) peptide, ... Authors: Roy, M.J, Hardy, J.M, Lucet, I.S. Deposit date: 2022-06-24 Release date: 2023-06-07 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structural mapping of PEAK pseudokinase interactions identifies 14-3-3 as a molecular switch for PEAK3 signaling. Nat Commun, 14, 2023
8R0Z	14-3-3 sigma in complex with TAZ peptide and stabilizing fragment TCF199 Descriptor: 14-3-3 protein sigma, MAGNESIUM ION, WW domain-containing transcription regulator protein 1, ... Authors: Centorrino, F, Andlovic, B, Ottmann, C. Deposit date: 2023-11-01 Release date: 2024-09-04 Last modified: 2024-09-11 Method: X-RAY DIFFRACTION (1.2 Å) Cite: Fragment-Based Interrogation of the 14-3-3/TAZ Protein-Protein Interaction. Biochemistry, 63, 2024
8DP5	Structure of the PEAK3/14-3-3 complex Descriptor: 14-3-3 protein beta/alpha, 14-3-3 protein epsilon, Protein PEAK3, ... Authors: Torosyan, H, Paul, M, Jura, N, Verba, K.A. Deposit date: 2022-07-14 Release date: 2023-06-28 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Structural insights into regulation of the PEAK3 pseudokinase scaffold by 14-3-3. Nat Commun, 14, 2023
4JC3	14-3-3 protein interaction with Estrogen Receptor Alpha provides a novel drug target interface Descriptor: 14-3-3 protein sigma, Estrogen receptor Peptide, MAGNESIUM ION Authors: Bier, D, Ottmann, C. Deposit date: 2013-02-21 Release date: 2013-05-15 Last modified: 2017-06-07 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Interaction of 14-3-3 proteins with the estrogen receptor alpha F domain provides a drug target interface. Proc. Natl. Acad. Sci. U.S.A., 110, 2013
1O9C	Structural view of a fungal toxin acting on a 14-3-3 regulatory complex Descriptor: 14-3-3-LIKE PROTEIN C, CHLORIDE ION, CITRATE ANION Authors: Wurtele, M, Jelich-Ottmann, C, Wittinghofer, A, Oecking, C. Deposit date: 2002-12-12 Release date: 2003-03-06 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural View of a Fungal Toxin Acting on a 14-3-3 Regulatory Complex Embo J., 22, 2003
1O9F	Structural view of a fungal toxin acting on a 14-3-3 regulatory complex Descriptor: 14-3-3-LIKE PROTEIN C, FUSICOCCIN, PLASMA MEMBRANE H+ ATPASE Authors: Wurtele, M, Jelich-Ottmann, C, Wittinghofer, A, Oecking, C. Deposit date: 2002-12-12 Release date: 2003-03-06 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structural View of a Fungal Toxin Acting on a 14-3-3 Regulatory Complex Embo J., 22, 2003

<12345678910111213141516>