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4AAJ	Structure of N-(5'-phosphoribosyl)anthranilate isomerase from Pyrococcus furiosus Descriptor: N-(5'-PHOSPHORIBOSYL)ANTHRANILATE ISOMERASE, SULFATE ION Authors: Repo, H, Oeemig, J.S, Djupsjobacka, J.B, Iwai, H, Heikinheimo, P. Deposit date: 2011-12-04 Release date: 2012-10-31 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.75 Å) Cite: A Monomeric Tim-Barrel Structure from Pyrococcus Furiosus is Optimized for Extreme Temperatures Acta Crystallogr.,Sect.D, 68, 2012
6Y2Y	The crystal structure of engineered cytochrome c peroxidase from Saccharomyces cerevisiae with Trp51 to S-Trp51 and Trp191Phe modifications Descriptor: 1,2-ETHANEDIOL, Cytochrome c peroxidase, mitochondrial, ... Authors: Ortmayer, M, Levy, C, Green, A.P. Deposit date: 2020-02-17 Release date: 2021-06-16 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.7 Å) Cite: A Noncanonical Tryptophan Analogue Reveals an Active Site Hydrogen Bond Controlling Ferryl Reactivity in a Heme Peroxidase. Jacs Au, 1, 2021
4YI7	Anthranilate bound at active site of anthranilate phosphoribosyl transferase from Acinetobacter (AnPRT; TrpD) Descriptor: 2-AMINOBENZOIC ACID, Anthranilate phosphoribosyltransferase Authors: Evans, G.L, Newton, M.S, Norris, G.E, Patrick, W.M. Deposit date: 2015-02-28 Release date: 2015-09-02 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.853 Å) Cite: Substrate inhibition of protein in tryptophan biosynthesis pathway redirects flux to aromatic catabolism in Acinetobacter baylyi ADP1. To Be Published
4M0R	Trianthranilate-like analogue bound to anthranilate phosphoribosyltransferase (AnPRT; TrpD). Descriptor: 2,6-bis[(2-carboxyphenyl)amino]benzoic acid, Anthranilate phosphoribosyltransferase, DIMETHYL SULFOXIDE, ... Authors: Evans, G.L, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC) Deposit date: 2013-08-02 Release date: 2014-05-21 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.96 Å) Cite: Repurposing the Chemical Scaffold of the Anti-Arthritic Drug Lobenzarit to Target Tryptophan Biosynthesis in Mycobacterium tuberculosis. Chembiochem, 15, 2014
2WUC	Crystal structure of HGFA in complex with the allosteric non- inhibitory antibody Fab40.deltaTrp and Ac-KQLR-chloromethylketone Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACE-KQLR-CHLOROMETHYLKETONE INHIBITOR, FAB FRAGMENT FAB40.DELTATRP HEAVY CHAIN, ... Authors: Ganesan, R, Eigenbrot, C, Shia, S. Deposit date: 2009-10-01 Release date: 2009-12-15 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Unraveling the Allosteric Mechanism of Serine Protease Inhibition by an Antibody Structure, 17, 2009
1LBM	CRYSTAL STRUCTURE OF PHOSPHORIBOSYL ANTHRANILATE ISOMERASE (PRAI) IN COMPLEX WITH REDUCED 1-(O-CARBOXYPHENYLAMINO)-1-DEOXYRIBULOSE 5-PHOSPHATE (RCDRP) Descriptor: 1-(O-CARBOXY-PHENYLAMINO)-1-DEOXY-D-RIBULOSE-5-PHOSPHATE, PHOSPHORIBOSYL ANTHRANILATE ISOMERASE Authors: Hennig, M, Sterner, R, Kirschner, K. Deposit date: 2002-04-04 Release date: 2002-12-18 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Two (betaalpha)(8)-barrel enzymes of histidine and tryptophan biosynthesis have similar reaction mechanisms and common strategies for protecting their labile substrates Biochemistry, 41, 2002
2WUB	Crystal structure of HGFA in complex with the allosteric non- inhibitory antibody Fab40.deltaTrp Descriptor: FAB FRAGMENT FAB40.DELTATRP HEAVY CHAIN, FAB FRAGMENT FAB40.DELTATRP LIGHT CHAIN, HEPATOCYTE GROWTH FACTOR ACTIVATOR LONG CHAIN, ... Authors: Ganesan, R, Eigenbrot, C, Shia, S. Deposit date: 2009-10-01 Release date: 2009-12-15 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Unraveling the Allosteric Mechanism of Serine Protease Inhibition by an Antibody Structure, 17, 2009
3TWP	Crystal structure of M. tuberculosis TrpD in complex with an inhibitor Descriptor: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 2-HYDROXYBENZOIC ACID, Anthranilate phosphoribosyltransferase, ... Authors: Castell, A, Short, F.L, Lott, J.S. Deposit date: 2011-09-22 Release date: 2012-09-26 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.83 Å) Cite: The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition. Biochemistry, 52, 2013
8BFR	The E. coli TrpD2 protein YbiB at 1.3 A resolution Descriptor: GLYCEROL, Protein YbiB Authors: Deckers, B, Galicia, C, Versees, W. Deposit date: 2022-10-26 Release date: 2023-02-22 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.3 Å) Cite: YbiB: a novel interactor of the GTPase ObgE. Nucleic Acids Res., 51, 2023
8BFT	The E. coli TrpD2 protein YbiB in complex with a C-terminal peptide from ObgE Descriptor: DI(HYDROXYETHYL)ETHER, GTPase ObgE/CgtA, Protein YbiB Authors: Deckers, B, Galicia, C, Versees, W. Deposit date: 2022-10-26 Release date: 2023-02-22 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.19 Å) Cite: YbiB: a novel interactor of the GTPase ObgE. Nucleic Acids Res., 51, 2023
4ZTV	Non-anthranilate-like inhibitor (TAMU-A7) complexed with anthranilate phosphoribosyltransferase (trpD) from Mycobacterium tuberculosis in absence of PRPP Descriptor: 4,4,4-trifluoro-1-(4-methoxyphenyl)butane-1,3-dione, Anthranilate phosphoribosyltransferase Authors: Evans, G.L, Eom, J, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC) Deposit date: 2015-05-15 Release date: 2016-05-25 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.01 Å) Cite: Bioactive non-anthranilate-like fragment-like inhibitor provides alternative starting point for inhibitor design against anthranilate phosphoribosyl transferase from Mycobacterium tuberculosis. To be Published
5BNE	Bianthranilate-like inhibitor with 6 atom "line" and phosphonate "hook" fishing for hydrogen bond donors in Mycobacterium tuberculosis anthranilate phosphoribosyltransferase (AnPRT; trpD) Descriptor: 2-[(2-carboxyphenyl)amino]-5-[(5-phosphonopentyl)oxy]benzoic acid, Anthranilate phosphoribosyltransferase, IMIDAZOLE Authors: Evans, G.L, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC) Deposit date: 2015-05-26 Release date: 2016-05-25 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Binding and mimicking of the phosphate-rich substrate, PRPP. To be Published
5BO2	Bianthranilate-like inhibitor with 4-atom "line" and phosphonate "hook" fishing for hydrogen bond donors in Mycobacterium tuberculosis anthranilate phosphoribosyltransferase (AnPRT; trpD) Descriptor: 2-[(2-carboxyphenyl)amino]-5-(3-phosphonopropoxy)benzoic acid, Anthranilate phosphoribosyltransferase, IMIDAZOLE Authors: Evans, G.L, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC) Deposit date: 2015-05-27 Release date: 2016-06-01 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2 Å) Cite: Binding and mimicking of the phosphate-rich substrate, PRPP. To be Published
5BYT	PRPP complexed with a single Mg in the active site of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase (AnPRT; trpD) Descriptor: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, Anthranilate phosphoribosyltransferase, MAGNESIUM ION Authors: Evans, G.L, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC) Deposit date: 2015-06-11 Release date: 2016-07-20 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2 Å) Cite: Binding and mimicking of the phosphate-rich substrate, PRPP. To be Published
5BO3	Bianthranilate-like inhibitor with 5 atom "line" and phosphonate "hook" fishing for hydrogen bond donors in Mycobacterium tuberculosis anthranilate phosphoribosyltransferase (AnPRT; trpD) Descriptor: 2-[(2-carboxyphenyl)amino]-5-(4-phosphonobutoxy)benzoic acid, Anthranilate phosphoribosyltransferase, IMIDAZOLE Authors: Evans, G.L, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC) Deposit date: 2015-05-27 Release date: 2016-06-01 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Binding and mimicking of the phosphate-rich substrate, PRPP. To be Published
3QR9	Anthranilate phosphoribosyltransferase (trpD) from Mycobacterium tuberculosis (apo structure) Descriptor: Anthranilate phosphoribosyltransferase, GLYCEROL Authors: Castell, A, Short, F.L, Lott, J.S, TB Structural Genomics Consortium (TBSGC) Deposit date: 2011-02-17 Release date: 2011-06-15 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.87 Å) Cite: The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition. Biochemistry, 52, 2013
3QS8	Anthranilate phosphoribosyltransferase (trpD) from Mycobacterium tuberculosis (complex with inhibitor ACS174) Descriptor: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 2-benzylbenzoic acid, Anthranilate phosphoribosyltransferase, ... Authors: Castell, A, Short, F.L, Lott, J.S, TB Structural Genomics Consortium (TBSGC) Deposit date: 2011-02-20 Release date: 2012-08-22 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2 Å) Cite: The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition. Biochemistry, 52, 2013
3QSA	Anthranilate phosphoribosyltransferase (trpD) from Mycobacterium tuberculosis (complex with inhibitor TAMU-A7) Descriptor: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 4,4,4-trifluoro-1-(4-methoxyphenyl)butane-1,3-dione, Anthranilate phosphoribosyltransferase, ... Authors: Castell, A, Short, F.L, Lott, J.S, TB Structural Genomics Consortium (TBSGC) Deposit date: 2011-02-20 Release date: 2012-08-22 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.18 Å) Cite: Inhibition of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase by blocking of an active site entrance tunnel. To be Published
5C1R	Stereoisomer of PRPP bound in the active site of Mycobacterium tuberculosis anthranilate phosphoribosyl (AnPRT; trpD) Descriptor: 5-O-[(R)-hydroxy(phosphonooxy)phosphoryl]-1-O-phosphono-alpha-D-ribofuranose, Anthranilate phosphoribosyltransferase, GLYCEROL, ... Authors: Evans, G.L, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC) Deposit date: 2015-06-15 Release date: 2016-07-20 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.802 Å) Cite: Binding and mimicking of the phosphate-rich substrate, PRPP. To Be Published
5C2L	Magnesium soaked into the active site of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase (AnPRT; trpD) Descriptor: Anthranilate phosphoribosyltransferase, IMIDAZOLE, MAGNESIUM ION Authors: Evans, G.L, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC) Deposit date: 2015-06-16 Release date: 2016-06-22 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.009 Å) Cite: Binding and mimicking of the phosphate-rich substrate, PRPP To Be Published
5C7S	PRPP complexed with two Mn2+ in the active site of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase (AnPRT; trpD) Descriptor: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, Anthranilate phosphoribosyltransferase, MANGANESE (II) ION Authors: Evans, G.L, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC) Deposit date: 2015-06-24 Release date: 2016-06-29 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Binding and mimicking of the phosphate-rich substrate, PRPP To Be Published
3QJA	Crystal Structure of the Mycobacterium tuberculosis Indole-3-glycerol phosphate synthase (TrpC) in apo form Descriptor: Indole-3-glycerol phosphate synthase, SULFATE ION Authors: Reddy, M.C.M, Bruning, J.B, Thurman, C, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) Deposit date: 2011-01-28 Release date: 2011-06-15 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.29 Å) Cite: Small-molecule scaffolds for Mycobacterium tuberculosis Indole Glycerol Phosphate Synthase (IGPS) inhibitors identified by high-throughput screening and defined by X-ray crystallography To be Published
3QQS	Anthranilate phosphoribosyltransferase (TRPD) from Mycobacterium tuberculosis (complex with inhibitor ACS172) Descriptor: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 2,2'-iminodibenzoic acid, Anthranilate phosphoribosyltransferase, ... Authors: Castell, A, Short, F.L, Lott, J.S, TB Structural Genomics Consortium (TBSGC) Deposit date: 2011-02-16 Release date: 2012-08-22 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.97 Å) Cite: The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition. Biochemistry, 52, 2013
3R88	Anthranilate phosphoribosyltransferase (trpD) from Mycobacterium tuberculosis (complex with inhibitor ACS145) Descriptor: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 2-amino-4,5-dimethoxybenzoic acid, Anthranilate phosphoribosyltransferase, ... Authors: Castell, A, Short, F.L, Lott, J.S. Deposit date: 2011-03-23 Release date: 2012-09-26 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.73 Å) Cite: The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition. Biochemistry, 52, 2013
3R6C	Anthranilate phosphoribosyltransferase (trpD) from Mycobacterium tuberculosis (complex with inhibitor ACS179) Descriptor: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 8-methoxyphenanthro[3,4-d][1,3]dioxole-5,6-dicarboxylic acid, Anthranilate phosphoribosyltransferase, ... Authors: Castell, A, Short, F.L, Lott, J.S, TB Structural Genomics Consortium (TBSGC) Deposit date: 2011-03-21 Release date: 2012-09-26 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.83 Å) Cite: The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition. Biochemistry, 52, 2013

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