2WUB

Crystal structure of HGFA in complex with the allosteric non- inhibitory antibody Fab40.deltaTrp

Summary for 2WUB

Entry DOI	10.2210/pdb2wub/pdb
Related	1YBW 1YC0 2WUC
Descriptor	HEPATOCYTE GROWTH FACTOR ACTIVATOR LONG CHAIN, HEPATOCYTE GROWTH FACTOR ACTIVATOR SHORT CHAIN, FAB FRAGMENT FAB40.DELTATRP HEAVY CHAIN, ... (6 entities in total)
Functional Keywords	hydrolase immune system complex, disulfide bond, serine protease, egf-like domain, allosteric inhibitor, kringle, zymogen, protease, secreted, antibody, hydrolase, fab complex, polymorphism, glycoprotein, hydrolase-immune system complex, hydrolase/immune system
Biological source	HOMO SAPIENS (HUMAN) More
Total number of polymer chains	8
Total formula weight	158709.95
Authors	Ganesan, R.,Eigenbrot, C.,Shia, S. (deposition date: 2009-10-01, release date: 2009-12-15, Last modification date: 2023-12-20)
Primary citation	Ganesan, R.,Eigenbrot, C.,Wu, Y.,Liang, W.C.,Shia, S.,Lipari, M.T.,Kirchhofer, D. Unraveling the Allosteric Mechanism of Serine Protease Inhibition by an Antibody Structure, 17:1614-, 2009 Cited by PubMed: 20004165 DOI: 10.1016/J.STR.2009.09.014 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation