PDB: 27348 resultsInfo pagesStatus searchChemie searchBIRD

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6USA	Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate- and GSK1-bound form Descriptor: (3R,4R)-4-[4-(2-Chlorophenyl)piperazin-1-yl]-1,1-dioxothiolan-3-ol, 1,2-ETHANEDIOL, 2-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]ACRYLIC ACID, ... Authors: Chang, C, Michalska, K, Maltseva, N.I, Jedrzejczak, R, McCarren, P, Nag, P.P, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) Deposit date: 2019-10-25 Release date: 2020-09-30 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.406 Å) Cite: Allosteric inhibitors of Mycobacterium tuberculosis tryptophan synthase. Protein Sci., 29, 2020
1DWB	CRYSTALLOGRAPHIC ANALYSIS AT 3.0-ANGSTROMS RESOLUTION OF THE BINDING TO HUMAN THROMBIN OF FOUR ACTIVE SITE-DIRECTED INHIBITORS Descriptor: ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), BENZAMIDINE, ... Authors: Banner, D.W, Hadvary, P. Deposit date: 1992-08-19 Release date: 1994-01-31 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (3.16 Å) Cite: Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors. J.Biol.Chem., 266, 1991
1DWD	CRYSTALLOGRAPHIC ANALYSIS AT 3.0-ANGSTROMS RESOLUTION OF THE BINDING TO HUMAN THROMBIN OF FOUR ACTIVE SITE-DIRECTED INHIBITORS Descriptor: 1-[N-(naphthalen-2-ylsulfonyl)glycyl-4-carbamimidoyl-D-phenylalanyl]piperidine, ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), ... Authors: Banner, D.W, Hadvary, P. Deposit date: 1992-08-19 Release date: 1994-01-31 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (3 Å) Cite: Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors. J.Biol.Chem., 266, 1991
1DWC	CRYSTALLOGRAPHIC ANALYSIS AT 3.0-ANGSTROMS RESOLUTION OF THE BINDING TO HUMAN THROMBIN OF FOUR ACTIVE SITE-DIRECTED INHIBITORS Descriptor: ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), HIRUDIN IIIA, ... Authors: Banner, D.W, Hadvary, P. Deposit date: 1992-08-19 Release date: 1994-01-31 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (3 Å) Cite: Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors. J.Biol.Chem., 266, 1991
1RIJ	E6-bind Trp-cage (E6apn1) Descriptor: E6apn1 peptide Authors: Liu, Y, Liu, Z, Androphy, E, Chen, J, Baleja, J.D. Deposit date: 2003-11-17 Release date: 2004-08-03 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Design and characterization of helical peptides that inhibit the E6 protein of papillomavirus. Biochemistry, 43, 2004
3BWN	L-tryptophan aminotransferase Descriptor: 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, L-tryptophan aminotransferase, PHENYLALANINE, ... Authors: Ferrer, J.-L, Noel, J.P, Pojer, F, Bowman, M, Chory, J, Tao, Y. Deposit date: 2008-01-10 Release date: 2008-04-29 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Rapid synthesis of auxin via a new tryptophan-dependent pathway is required for shade avoidance in plants Cell(Cambridge,Mass.), 133, 2008
1BEE	HALOALKANE DEHALOGENASE MUTANT WITH TRP 175 REPLACED BY TYR Descriptor: HALOALKANE DEHALOGENASE Authors: Ridder, I.S, Vos, G.J, Rozeboom, H.J, Kalk, K.H, Dijkstra, B.W. Deposit date: 1998-05-13 Release date: 1998-11-11 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Kinetic analysis and X-ray structure of haloalkane dehalogenase with a modified halide-binding site. Biochemistry, 37, 1998
1BEZ	HALOALKANE DEHALOGENASE MUTANT WITH TRP 175 REPLACED BY TYR AT PH 5 Descriptor: ACETIC ACID, HALOALKANE DEHALOGENASE Authors: Ridder, I.S, Vos, G.J, Rozeboom, H.J, Kalk, K.H, Dijkstra, B.W. Deposit date: 1998-05-18 Release date: 1998-11-11 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Kinetic analysis and X-ray structure of haloalkane dehalogenase with a modified halide-binding site. Biochemistry, 37, 1998
2DH6	Crystal structure of E. coli Apo-TrpB Descriptor: SULFATE ION, tryptophan synthase beta subunit Authors: Nishio, K, Morimoto, Y, Ogasahara, K, Yasuoka, N, Yutani, K, Tsukihara, T, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2006-03-23 Release date: 2007-04-24 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (3 Å) Cite: Large conformational changes in the Escherichia coli tryptophan synthase beta(2) subunit upon pyridoxal 5'-phosphate binding Febs J., 277, 2010
2DH5	Crystal structure of E. coli Holo-TrpB Descriptor: GLYCEROL, PYRIDOXAL-5'-PHOSPHATE, SULFATE ION, ... Authors: Nishio, K, Morimoto, Y, Ogasahara, K, Yutani, K, Tsukihara, T, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2006-03-23 Release date: 2007-04-24 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Large conformational changes in the Escherichia coli tryptophan synthase beta(2) subunit upon pyridoxal 5'-phosphate binding Febs J., 277, 2010
2TRS	CRYSTAL STRUCTURES OF MUTANT (BETAK87T) TRYPTOPHAN SYNTHASE ALPHA2 BETA2 COMPLEX WITH LIGANDS BOUND TO THE ACTIVE SITES OF THE ALPHA AND BETA SUBUNITS REVEAL LIGAND-INDUCED CONFORMATIONAL CHANGES Descriptor: INDOLE-3-PROPANOL PHOSPHATE, SODIUM ION, TRYPTOPHAN SYNTHASE, ... Authors: Rhee, S, Parris, K.D, Hyde, C.C, Ahmed, S.A, Miles, E.W, Davies, D.R. Deposit date: 1997-01-07 Release date: 1997-04-01 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.04 Å) Cite: Crystal structures of a mutant (betaK87T) tryptophan synthase alpha2beta2 complex with ligands bound to the active sites of the alpha- and beta-subunits reveal ligand-induced conformational changes. Biochemistry, 36, 1997
2TSY	CRYSTAL STRUCTURES OF MUTANT (BETAK87T) TRYPTOPHAN SYNTHASE ALPHA2 BETA2 COMPLEX WITH LIGANDS BOUND TO THE ACTIVE SITES OF THE ALPHA AND BETA SUBUNITS REVEAL LIGAND-INDUCED CONFORMATIONAL CHANGES Descriptor: SN-GLYCEROL-3-PHOSPHATE, SODIUM ION, TRYPTOPHAN SYNTHASE, ... Authors: Rhee, S, Parris, K.D, Hyde, C.C, Ahmed, S.A, Miles, E.W, Davies, D.R. Deposit date: 1997-01-03 Release date: 1997-04-01 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Crystal structures of a mutant (betaK87T) tryptophan synthase alpha2beta2 complex with ligands bound to the active sites of the alpha- and beta-subunits reveal ligand-induced conformational changes. Biochemistry, 36, 1997
2TYS	CRYSTAL STRUCTURES OF MUTANT (BETAK87T) TRYPTOPHAN SYNTHASE ALPHA2 BETA2 COMPLEX WITH LIGANDS BOUND TO THE ACTIVE SITES OF THE ALPHA AND BETA SUBUNITS REVEAL LIGAND-INDUCED CONFORMATIONAL CHANGES Descriptor: SODIUM ION, TRYPTOPHAN SYNTHASE, [3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL]-L-TRYPTOPHANE Authors: Rhee, S, Parris, K.D, Hyde, C.C, Ahmed, S.A, Miles, E.W, Davies, D.R. Deposit date: 1997-01-08 Release date: 1997-04-01 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structures of a mutant (betaK87T) tryptophan synthase alpha2beta2 complex with ligands bound to the active sites of the alpha- and beta-subunits reveal ligand-induced conformational changes. Biochemistry, 36, 1997
2CEP	ROLE OF MET-230 IN INTRAMOLECULAR ELECTRON TRANSFER BETWEEN THE OXYFERRYL HEME AND TRP 191 IN CYTOCHROME C PEROXIDASE COMPOUND II Descriptor: CYTOCHROME C PEROXIDASE, PROTOPORPHYRIN IX CONTAINING FE Authors: Han, G.W, Miller, M.A, Kraut, J. Deposit date: 1994-05-31 Release date: 1994-08-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Role of methionine 230 in intramolecular electron transfer between the oxyferryl heme and tryptophan 191 in cytochrome c peroxidase compound II. Biochemistry, 33, 1994
2WSY	CRYSTAL STRUCTURE OF WILD-TYPE TRYPTOPHAN SYNTHASE Descriptor: PYRIDOXAL-5'-PHOSPHATE, SODIUM ION, TRYPTOPHAN SYNTHASE Authors: Schneider, T.R, Gerhardt, E, Lee, M, Liang, P.-H, Anderson, K.S, Schlichting, I. Deposit date: 1998-02-18 Release date: 1999-03-30 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (3.05 Å) Cite: Loop closure and intersubunit communication in tryptophan synthase. Biochemistry, 37, 1998
1TJP	Crystal Structure Of Wild-Type Tryptophan Synthase Complexed With 1-[(2-hydroxylphenyl)amino]3-glycerolphosphate Descriptor: 1-[(2-HYDROXYLPHENYL)AMINO]3-GLYCEROLPHOSPHATE, PYRIDOXAL-5'-PHOSPHATE, SODIUM ION, ... Authors: Kulik, V, Hartmann, E, Weyand, M, Frey, M, Gierl, A, Niks, D, Dunn, M.F, Schlichting, I. Deposit date: 2004-06-07 Release date: 2005-12-27 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.5 Å) Cite: On the structural basis of the catalytic mechanism and the regulation of the alpha subunit of tryptophan synthase from Salmonella typhimurium and BX1 from maize, two evolutionarily related enzymes. J.Mol.Biol., 352, 2005
6QKY	Tryptophan synthase subunit alpha from Streptococcus pneumoniae with 3D domain swap in the core of TIM barrel Descriptor: ACETIC ACID, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... Authors: Michalska, K, Kowiel, M, Bigelow, L, Endres, M, Gilski, M, Jaskolski, M, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) Deposit date: 2019-01-30 Release date: 2019-03-27 Last modified: 2022-03-30 Method: X-RAY DIFFRACTION (2.54 Å) Cite: 3D domain swapping in the TIM barrel of the alpha subunit of Streptococcus pneumoniae tryptophan synthase. Acta Crystallogr D Struct Biol, 76, 2020
1A75	WHITING PARVALBUMIN Descriptor: CALCIUM ION, PARVALBUMIN Authors: Declercq, J.P, Baneres, J.L, Rambaud, J, Parello, J. Deposit date: 1998-03-19 Release date: 1998-06-17 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Tertiary Structure of a Trp-Containing Parvalbumin from Whiting (Merlangius Merlangus). Description of the Hydrophobic Core To be Published
1UBS	TRYPTOPHAN SYNTHASE (E.C.4.2.1.20) WITH A MUTATION OF LYS 87->THR IN THE B SUBUNIT AND IN THE PRESENCE OF LIGAND L-SERINE Descriptor: PYRIDOXAL-5'-PHOSPHATE, SERINE, SODIUM ION, ... Authors: Rhee, S, Parris, K, Ahmed, S.A, Miles, E.W, Davies, D.R. Deposit date: 1995-12-14 Release date: 1996-03-08 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structures of a mutant (betaK87T) tryptophan synthase alpha2beta2 complex with ligands bound to the active sites of the alpha- and beta-subunits reveal ligand-induced conformational changes. Biochemistry, 36, 1997
7ELT	Crystal structure of Mycobacterium tuberculosis tryptophanyl-tRNA synthetase complexed with Trp-AMP Descriptor: TRYPTOPHANYL-5'AMP, Tryptophan--tRNA ligase Authors: Xu, M, Chen, S. Deposit date: 2021-04-12 Release date: 2022-02-16 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Investigate Natural Product Indolmycin and the Synthetically Improved Analogue Toward Antimycobacterial Agents. Acs Chem.Biol., 17, 2022
3EQ3	Model of tRNA(Trp)-EF-Tu in the ribosomal pre-accommodated state revealed by cryo-EM Descriptor: 30S ribosomal protein S12, 50S ribosomal protein L11, Elongation factor Tu, ... Authors: Frank, J, Li, W, Agirrezabala, X. Deposit date: 2008-09-30 Release date: 2008-12-16 Last modified: 2024-02-21 Method: ELECTRON MICROSCOPY (9 Å) Cite: Recognition of aminoacyl-tRNA: a common molecular mechanism revealed by cryo-EM. Embo J., 27, 2008
2E3X	Crystal structure of Russell's viper venom metalloproteinase Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(N-HYDROXYCARBOXAMIDO)-2-ISOBUTYLPROPANOYL-TRP-METHYLAMIDE, ... Authors: Igarashi, T, Takeda, S. Deposit date: 2006-11-30 Release date: 2007-12-11 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (2.91 Å) Cite: Crystal structure of RVV-X: an example of evolutionary gain of specificity by ADAM proteinases. Febs Lett., 581, 2007
1HDE	HALOALKANE DEHALOGENASE MUTANT WITH PHE 172 REPLACED WITH TRP Descriptor: HALOALKANE DEHALOGENASE Authors: Ridder, I.S, Kalk, K.H, Dijkstra, B.W. Deposit date: 1996-08-08 Release date: 1997-02-12 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Kinetic characterization and X-ray structure of a mutant of haloalkane dehalogenase with higher catalytic activity and modified substrate range. Biochemistry, 35, 1996
2ERP	Crystal structure of vascular apoptosis-inducing protein-1(inhibitor-bound form) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(N-HYDROXYCARBOXAMIDO)-2-ISOBUTYLPROPANOYL-TRP-METHYLAMIDE, CALCIUM ION, ... Authors: Takeda, S, Igarashi, T, Araki, S. Deposit date: 2005-10-25 Release date: 2006-06-20 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (2.95 Å) Cite: Crystal structures of VAP1 reveal ADAMs' MDC domain architecture and its unique C-shaped scaffold Embo J., 25, 2006
7LKI	The crystal structure of Epitope III of HCV envelop protein E2 in complex with antibody 1H8 Descriptor: Epitope III peptide GLY-ALA-PRO-THR-TYR-SER-TRP-GLY, antibody 1H8 heavy chain, antibody 1H8 light chain Authors: Deng, L, Zhang, P. Deposit date: 2021-02-02 Release date: 2021-08-04 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2 Å) Cite: A conserved epitope III on hepatitis C virus E2 protein has alternate conformations facilitating cell binding or virus neutralization. Proc.Natl.Acad.Sci.USA, 118, 2021

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