6USA

Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate- and GSK1-bound form

Summary for 6USA

Entry DOI	10.2210/pdb6usa/pdb
Descriptor	Tryptophan synthase alpha chain, ACETATE ION, SULFATE ION, ... (13 entities in total)
Functional Keywords	plp, heterotetramer, amino acid biosynthesis, substrate channeling, lyase-lyase inhibitor complex, lyase/lyase inhibitor
Biological source	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) More
Total number of polymer chains	8
Total formula weight	293528.25
Authors	Chang, C.,Michalska, K.,Maltseva, N.I.,Jedrzejczak, R.,McCarren, P.,Nag, P.P.,Joachimiak, A.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2019-10-25, release date: 2020-09-30, Last modification date: 2023-10-25)
Primary citation	Michalska, K.,Chang, C.,Maltseva, N.I.,Jedrzejczak, R.,Robertson, G.T.,Gusovsky, F.,McCarren, P.,Schreiber, S.L.,Nag, P.P.,Joachimiak, A. Allosteric inhibitors of Mycobacterium tuberculosis tryptophan synthase. Protein Sci., 29:779-788, 2020 Cited by PubMed: 31930594 DOI: 10.1002/pro.3825 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.406 Å)

Structure validation