6USA
Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate- and GSK1-bound form
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C, E, G | Tryptophan synthase alpha chain | polymer | 276 | 28579.4 | 4 | UniProt (P9WFY1) Pfam (PF00290) In PDB | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | |
2 | B, D, F, H | Tryptophan synthase beta chain | polymer | 410 | 43334.6 | 4 | UniProt (P9WFX9) Pfam (PF00291) In PDB | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | |
3 | D, A, G, B, E... | FORMIC ACID | non-polymer | 46.0 | 28 | Chemie (FMT) | |||
4 | F, A, D, G, E... | MALONATE ION | non-polymer | 102.0 | 6 | Chemie (MLI) | |||
5 | B, H, F, D | (3R,4R)-4-[4-(2-Chlorophenyl)piperazin-1-yl]-1,1-dioxothiolan-3-ol | non-polymer | 330.8 | 4 | Chemie (PZJ) | |||
6 | B, H, F, D | 2-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]ACRYLIC ACID | non-polymer | 318.2 | 4 | Chemie (P1T) | |||
7 | F, D, G, B, H | POTASSIUM ION | non-polymer | 39.1 | 10 | Chemie (K) | |||
8 | F, D, G, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 9 | Chemie (EDO) | |||
9 | C | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
10 | D, F | ACETATE ION | non-polymer | 59.0 | 3 | Chemie (ACT) | |||
11 | H | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
12 | H | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
13 | water | water | 18.0 | 1234 | Chemie (HOH) |
Sequence modifications
A, C, E, G: 1 - 270 (UniProt: P9WFY1)
PDB | External Database | Details |
---|---|---|
His 271 | - | expression tag |
His 272 | - | expression tag |
His 273 | - | expression tag |
His 274 | - | expression tag |
His 275 | - | expression tag |
His 276 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 287656.2 | |
Non-Polymers* | Number of molecules | 68 |
Total formula weight | 5872.1 | |
All* | Total formula weight | 293528.3 |