7N1I
 
 | | CryoEM structure of Venezuelan equine encephalitis virus VLP | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Capsid, E1 envelope glycoprotein, ... | | Authors: | Basore, K, Nelson, C.A, Fremont, D.H, Center for Structural Genomics of Infectious Diseases (CSGID) | | Deposit date: | 2021-05-27 | | Release date: | 2021-10-13 | | Last modified: | 2021-11-10 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Structure of Venezuelan equine encephalitis virus in complex with the LDLRAD3 receptor.
Nature, 598, 2021
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7Z8O
 | | Crystal structure of SARS-CoV-2 S RBD in complex with a stapled peptide | | Descriptor: | 2,4,6-tris(chloromethyl)-1,3,5-triazine, GLYCEROL, Spike protein S1, ... | | Authors: | Brear, P, Chen, L, Gaynor, K, Harman, M, Dods, R, Hyvonen, M. | | Deposit date: | 2022-03-18 | | Release date: | 2023-06-28 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (0.96 Å) | | Cite: | Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit SARS-CoV-2.
Nat Commun, 14, 2023
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4PZ1
 | | Crystal structure of a sHIP (UniProt Id: Q99XU0) mutant from Streptococcus pyogenes | | Descriptor: | CALCIUM ION, CHLORIDE ION, sHIP | | Authors: | Wisniewska, M, Happonen, L, Frick, I.-M, Bjorck, L, Streicher, W, Malmstrom, J, Wikstrom, M. | | Deposit date: | 2014-03-28 | | Release date: | 2015-03-11 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.73 Å) | | Cite: | Functional and structural properties of a novel protein and virulence factor (Protein sHIP) in Streptococcus pyogenes.
J.Biol.Chem., 289, 2014
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7NP9
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5C1M
 | | Crystal structure of active mu-opioid receptor bound to the agonist BU72 | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2R,3S,3aR,5aR,6R,11bR,11cS)-3a-methoxy-3,14-dimethyl-2-phenyl-2,3,3a,6,7,11c-hexahydro-1H-6,11b-(epiminoethano)-3,5a-methanonaphtho[2,1-g]indol-10-ol, CHOLESTEROL, ... | | Authors: | Huang, W.J, Manglik, A, Venkatakrishnan, A.J, Laeremans, T, Feinberg, E.N, Sanborn, A.L, Kato, H.E, Livingston, K.E, Thorsen, T.S, Kling, R, Granier, S, Gmeiner, P, Husbands, S.M, Traynor, J.R, Weis, W.I, Steyaert, J, Dror, R.O, Kobilka, B.K. | | Deposit date: | 2015-06-15 | | Release date: | 2015-08-05 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.07 Å) | | Cite: | Structural insights into mu-opioid receptor activation.
Nature, 524, 2015
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7N0A
 | | Structure of Human Leukaemia Inhibitory Factor with Fab MSC1 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Leukemia inhibitory factor, ... | | Authors: | Raman, S, Bosch, A, Fransson, J, Julien, J.P. | | Deposit date: | 2021-05-25 | | Release date: | 2022-06-15 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Therapeutic Targeting of LIF Overcomes Macrophage-mediated Immunosuppression of the Local Tumor Microenvironment.
Clin.Cancer Res., 29, 2023
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7N69
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7N6A
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7YTE
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7YTD
 | | Cryo-EM structure of four human FcmR bound to IgM-Fc/J | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fas apoptotic inhibitory molecule 3, Immunoglobulin J chain, ... | | Authors: | Li, Y, Shen, H, Xiao, J. | | Deposit date: | 2022-08-14 | | Release date: | 2023-02-01 | | Last modified: | 2023-05-03 | | Method: | ELECTRON MICROSCOPY (3.71 Å) | | Cite: | Immunoglobulin M perception by Fc mu R.
Nature, 615, 2023
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7YSG
 | | Cryo-EM structure of human FcmR bound to sIgM | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fas apoptotic inhibitory molecule 3, ... | | Authors: | Li, Y, Shen, H, Xiao, J. | | Deposit date: | 2022-08-12 | | Release date: | 2023-02-01 | | Last modified: | 2023-05-03 | | Method: | ELECTRON MICROSCOPY (3.18 Å) | | Cite: | Immunoglobulin M perception by Fc mu R.
Nature, 615, 2023
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7YTC
 | | Cryo-EM structure of human FcmR bound to IgM-Fc/J | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fas apoptotic inhibitory molecule 3, Immunoglobulin J chain, ... | | Authors: | Li, Y, Shen, H, Xiao, J. | | Deposit date: | 2022-08-14 | | Release date: | 2023-02-01 | | Last modified: | 2023-05-03 | | Method: | ELECTRON MICROSCOPY (3.39 Å) | | Cite: | Immunoglobulin M perception by Fc mu R.
Nature, 615, 2023
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7NX2
 | | Unbound antigen-binding fragment (FAb) 324 | | Descriptor: | FAb 324 Heavy Chain, FAb 324 Light Chain, SULFATE ION | | Authors: | De Munck, S, Savvides, S.N. | | Deposit date: | 2021-03-17 | | Release date: | 2021-10-27 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.47 Å) | | Cite: | Structural basis of cytokine-mediated activation of ALK family receptors.
Nature, 600, 2021
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5D6K
 | | PepT - CIM | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-hexadec-9-enoate, (2S)-2,3-dihydroxypropyl (9Z)-hexadec-9-enoate, Di-or tripeptide:H+ symporter, ... | | Authors: | Ma, P, Caffrey, M. | | Deposit date: | 2015-08-12 | | Release date: | 2016-08-17 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | The cubicon method for concentrating membrane proteins in the cubic mesophase.
Nat Protoc, 12, 2017
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7NBX
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7ND0
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7NCS
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7O4W
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8A58
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4ZXB
 | | Structure of the human insulin receptor ectodomain, IRDeltabeta construct, in complex with four Fab molecules | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Croll, T, Smith, B.J, Margetts, M.B, Whittaker, J, Weiss, M.A, Ward, C.W, Lawrence, M.C. | | Deposit date: | 2015-05-20 | | Release date: | 2016-02-24 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Higher-Resolution Structure of the Human Insulin Receptor Ectodomain: Multi-Modal Inclusion of the Insert Domain.
Structure, 24, 2016
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5D41
 | | EGFR kinase domain in complex with mutant selective allosteric inhibitor | | Descriptor: | (2R)-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)-2-phenyl-N-(1,3-thiazol-2-yl)acetamide, Epidermal growth factor receptor, MAGNESIUM ION, ... | | Authors: | Yun, C.-H, Park, E, Eck, M.J. | | Deposit date: | 2015-08-07 | | Release date: | 2016-06-08 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.31 Å) | | Cite: | Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors.
Nature, 534, 2016
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5AAO
 | | Crystal structure of fluorogen-activating designed ankyrin repeat protein (DARPin) dimer in complex with malachite green | | Descriptor: | 4-[[4-(dimethylamino)cyclohexa-2,5-dien-1-ylidene]-(4-methoxyphenyl)methyl]-N,N-dimethyl-aniline, FAD3210 | | Authors: | Batyuk, A, Schuetz, M, Kummer, L, Wu, Y, Mittl, P, Plueckthun, A. | | Deposit date: | 2015-07-27 | | Release date: | 2016-02-03 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Generation of Fluorogen-Activating Designed Ankyrin Repeat Proteins (FADAs) as Versatile Sensor Tools.
J. Mol. Biol., 428, 2016
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5D3G
 | | Structure of HIV-1 Reverse Transcriptase Bound to a Novel 38-mer Hairpin Template-Primer DNA Aptamer | | Descriptor: | DNA aptamer (38-MER), GLYCEROL, HIV-1 REVERSE TRANSCRIPTASE P51 subunit, ... | | Authors: | Miller, M.T, Tuske, S, Das, K, Arnold, E. | | Deposit date: | 2015-08-06 | | Release date: | 2015-09-30 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structure of HIV-1 reverse transcriptase bound to a novel 38-mer hairpin template-primer DNA aptamer.
Protein Sci., 25, 2016
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4PFE
 | | Crystal structure of vsfGFP-0 | | Descriptor: | Green fluorescent protein | | Authors: | Jauch, R, Chen, S.L. | | Deposit date: | 2014-04-29 | | Release date: | 2015-06-24 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.603 Å) | | Cite: | Rational Structure-Based Design of Bright GFP-Based Complexes with Tunable Dimerization.
Angew.Chem.Int.Ed.Engl., 54, 2015
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5D6I
 | | DgkA - CIM | | Descriptor: | Diacylglycerol kinase | | Authors: | Ma, P, Caffrey, M. | | Deposit date: | 2015-08-12 | | Release date: | 2016-08-17 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (3.091 Å) | | Cite: | The cubicon method for concentrating membrane proteins in the cubic mesophase.
Nat Protoc, 12, 2017
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