PDB: 17121 resultsInfo pagesStatus searchChemie searchBIRD

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8D82	Cryo-EM structure of human IL-6 signaling complex in detergent: model containing full extracellular domains Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-6, ... Authors: Zhou, Y, Franklin, M.C. Deposit date: 2022-06-07 Release date: 2023-03-29 Last modified: 2025-05-28 Method: ELECTRON MICROSCOPY (3.22 Å) Cite: Structural insights into the assembly of gp130 family cytokine signaling complexes. Sci Adv, 9, 2023
8FYE	4-F, 5-MeO-PyrT-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex Descriptor: 4-fluoro-5-methoxy-3-[2-(pyrrolidin-1-yl)ethyl]-1H-indole, CHOLESTEROL HEMISUCCINATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... Authors: Warren, A.L, Zilberg, G, Capper, M.J, Wacker, D. Deposit date: 2023-01-26 Release date: 2024-05-15 Last modified: 2024-10-23 Method: ELECTRON MICROSCOPY (2.85 Å) Cite: Structural pharmacology and therapeutic potential of 5-methoxytryptamines. Nature, 630, 2024
8FY8	5-MeO-DMT-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex Descriptor: 2-(5-methoxy-1H-indol-3-yl)-N,N-dimethylethan-1-amine, CHOLESTEROL HEMISUCCINATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... Authors: Warren, A.L, Zilberg, G, Capper, M.J, Wacker, D. Deposit date: 2023-01-25 Release date: 2024-05-15 Last modified: 2024-10-30 Method: ELECTRON MICROSCOPY (2.79 Å) Cite: Structural pharmacology and therapeutic potential of 5-methoxytryptamines. Nature, 630, 2024
5T3J	Histidinol Phosphate Phosphatase(HPP) soaked with selenourea for 10 min Descriptor: Inositol monophosphatase, PHOSPHATE ION, selenourea Authors: Luo, Z, Dauter, Z. Deposit date: 2016-08-25 Release date: 2016-11-30 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Selenourea: a convenient phasing vehicle for macromolecular X-ray crystal structures. Sci Rep, 6, 2016
8FYL	Vilazodone-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex Descriptor: 5-{4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl}-1-benzofuran-2-carboxamide, CHOLESTEROL HEMISUCCINATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... Authors: Warren, A.L, Zilberg, G, Capper, M.J, Wacker, D. Deposit date: 2023-01-26 Release date: 2024-05-15 Last modified: 2024-10-23 Method: ELECTRON MICROSCOPY (2.94 Å) Cite: Structural pharmacology and therapeutic potential of 5-methoxytryptamines. Nature, 630, 2024
8FYT	LSD-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex Descriptor: (8alpha)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide, CHOLESTEROL HEMISUCCINATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... Authors: Warren, A.L, Zilberg, G, Capper, M.J, Wacker, D. Deposit date: 2023-01-26 Release date: 2024-05-15 Last modified: 2024-10-16 Method: ELECTRON MICROSCOPY (2.64 Å) Cite: Structural pharmacology and therapeutic potential of 5-methoxytryptamines. Nature, 630, 2024
8FYX	Buspirone-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex Descriptor: Buspirone, CHOLESTEROL HEMISUCCINATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... Authors: Warren, A.L, Zilberg, G, Capper, M.J, Wacker, D. Deposit date: 2023-01-26 Release date: 2024-05-15 Last modified: 2024-11-06 Method: ELECTRON MICROSCOPY (2.62 Å) Cite: Structural pharmacology and therapeutic potential of 5-methoxytryptamines. Nature, 630, 2024
5T47	Crystal structure of the D. melanogaster eIF4E-eIF4G complex Descriptor: Eukaryotic translation initiation factor 4E, Eukaryotic translation initiation factor 4G, isoform A, ... Authors: Gruener, S, Peter, D, Weber, R, Wohlbold, L, Chung, M.-Y, Weichenrieder, O, Valkov, E, Igreja, C, Izaurralde, E. Deposit date: 2016-08-29 Release date: 2016-10-26 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.2 Å) Cite: The Structures of eIF4E-eIF4G Complexes Reveal an Extended Interface to Regulate Translation Initiation. Mol.Cell, 64, 2016
6RFS	Cryo-EM structure of a respiratory complex I mutant lacking NDUFS4 Descriptor: Acyl carrier protein ACPM1 of NADH:Ubiquinone Oxidoreductase (Complex I), Acyl carrier protein ACPM2 of NADH:Ubiquinone Oxidoreductase (Complex I), FE2/S2 (INORGANIC) CLUSTER, ... Authors: Parey, K, Vonck, J. Deposit date: 2019-04-16 Release date: 2019-12-11 Last modified: 2024-11-20 Method: ELECTRON MICROSCOPY (4.04 Å) Cite: High-resolution cryo-EM structures of respiratory complex I: Mechanism, assembly, and disease. Sci Adv, 5, 2019
5CU5	Crystal structure of ERAP2 without catalytic Zn(II) atom Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Endoplasmic reticulum aminopeptidase 2, ... Authors: Saridakis, E, Mathioudakis, N, Giastas, P, Mavridis, I.M, Stratikos, E. Deposit date: 2015-07-24 Release date: 2015-09-23 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (3.02 Å) Cite: Structural Basis for Antigenic Peptide Recognition and Processing by Endoplasmic Reticulum (ER) Aminopeptidase 2. J.Biol.Chem., 290, 2015
8BHL	Elongating E. coli 70S ribosome containing acylated tRNA(iMet) in the P-site and Am6AA mRNA codon in the A-site after uncompleted di-peptide formation Descriptor: 16S rRNA RRSB-RRNA, 23S rRNA RRLG-RRNA, 30S ribosomal protein S10, ... Authors: Koziej, L, Glatt, S. Deposit date: 2022-10-31 Release date: 2023-08-16 Method: ELECTRON MICROSCOPY (2.21 Å) Cite: Modulation of translational decoding by m 6 A modification of mRNA. Nat Commun, 14, 2023
8BHP	Elongating E. coli 70S ribosome containing acylated tRNA(iMet) in the P-site and m6AAA mRNA codon in the A-site after uncompleted di-peptide formation Descriptor: 16S rRNA RRSB-RRNA, 23S rRNA RRLG-RRNA, 30S ribosomal protein S10, ... Authors: Koziej, L, Glatt, S. Deposit date: 2022-10-31 Release date: 2023-08-16 Method: ELECTRON MICROSCOPY (2.37 Å) Cite: Modulation of translational decoding by m 6 A modification of mRNA. Nat Commun, 14, 2023
8HMV	Structure of GPR21-Gs complex Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... Authors: Wong, T.S, Gao, W. Deposit date: 2022-12-05 Release date: 2023-03-01 Last modified: 2025-07-23 Method: ELECTRON MICROSCOPY (2.91 Å) Cite: Cryo-EM structure of orphan G protein-coupled receptor GPR21. MedComm (2020), 4, 2023
8HS3	Gi bound orphan GPR20 in ligand-free state Descriptor: Ggama, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... Authors: Lin, X, Jiang, S, Xu, F. Deposit date: 2022-12-16 Release date: 2023-03-08 Last modified: 2025-07-02 Method: ELECTRON MICROSCOPY (3.14 Å) Cite: The activation mechanism and antibody binding mode for orphan GPR20. Cell Discov, 9, 2023
8HSC	Gi bound Orphan GPR20 complex with Fab046 in ligand-free state Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... Authors: Lin, X, Jiang, S, Xu, F. Deposit date: 2022-12-19 Release date: 2023-03-08 Last modified: 2025-06-25 Method: ELECTRON MICROSCOPY (3.22 Å) Cite: The activation mechanism and antibody binding mode for orphan GPR20. Cell Discov, 9, 2023
8HJ2	GPR21 wt with G15 complex Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... Authors: Chen, B, Lin, X, Xu, F. Deposit date: 2022-11-22 Release date: 2023-03-15 Last modified: 2025-07-02 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Cryo-EM structures of orphan GPR21 signaling complexes. Nat Commun, 14, 2023
8H6J	Cryo-EM structure of human exon-defined spliceosome in the mature pre-B state. Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... Authors: Zhang, W, Zhan, X, Zhang, X, Lei, J, Yan, C, Shi, Y. Deposit date: 2022-10-18 Release date: 2024-05-01 Last modified: 2025-07-16 Method: ELECTRON MICROSCOPY (3.25 Å) Cite: Structural insights into human exon-defined spliceosome prior to activation. Cell Res., 34, 2024
8H6E	Cryo-EM structure of human exon-defined spliceosome in the late pre-B state. Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... Authors: Zhang, W, Zhan, X, Zhang, X, Bai, R, Lei, J, Yan, C, Shi, Y. Deposit date: 2022-10-17 Release date: 2024-05-01 Last modified: 2025-07-16 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structural insights into human exon-defined spliceosome prior to activation. Cell Res., 34, 2024
5TJ7	Structure of WWP2 WW2-2,3-linker-HECT aa 334-398 linked to 485-865 Descriptor: CHLORIDE ION, NEDD4-like E3 ubiquitin-protein ligase WWP2, SODIUM ION, ... Authors: Chen, Z, Gabelli, S.B. Deposit date: 2016-10-03 Release date: 2017-05-31 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (2.6 Å) Cite: A Tunable Brake for HECT Ubiquitin Ligases. Mol. Cell, 66, 2017
5TJQ	Structure of WWP2 2,3-linker-HECT Descriptor: NEDD4-like E3 ubiquitin-protein ligase WWP2,NEDD4-like E3 ubiquitin-protein ligase WWP2 Authors: Chen, Z, Gabelli, S.B. Deposit date: 2016-10-04 Release date: 2017-05-31 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (2.75 Å) Cite: A Tunable Brake for HECT Ubiquitin Ligases. Mol. Cell, 66, 2017
5DFJ	Human APE1 E96Q/D210N mismatch substrate complex Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*TP*(3DR)P*CP*GP*AP*CP*GP*GP*AP*TP*CP*C)-3'), ... Authors: Freudenthal, B.D, Wilson, S.H. Deposit date: 2015-08-26 Release date: 2015-10-14 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Capturing snapshots of APE1 processing DNA damage. Nat.Struct.Mol.Biol., 22, 2015
8GAG	Cannabinoid receptor 1-Gi complex with novel ligand Descriptor: Cannabinoid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... Authors: Tummino, T.A, Iliopoulos-Tsoutsouvas, C, Braz, J.M, O'Brien, E.S, Krishna Kumar, K, Makriyannis, M, Basbaum, A.I, Shoichet, B.K. Deposit date: 2023-02-22 Release date: 2024-02-28 Last modified: 2025-06-04 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Cannabinoid receptor 1-Gi complex with novel ligand To Be Published
8GG5	CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #11 of 20) Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Papasergi-Scott, M.M, Skiniotis, G. Deposit date: 2023-03-08 Release date: 2024-03-06 Last modified: 2024-11-06 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
5DFH	Human APE1 mismatch product complex Descriptor: 1,2-ETHANEDIOL, DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*T)-3'), DNA (5'-D(*GP*GP*AP*TP*CP*CP*GP*TP*CP*GP*GP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ... Authors: Freudenthal, B.D, Wilson, S.H. Deposit date: 2015-08-26 Release date: 2015-10-14 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.949 Å) Cite: Capturing snapshots of APE1 processing DNA damage. Nat.Struct.Mol.Biol., 22, 2015
8GG6	CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #12 of 20) Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Papasergi-Scott, M.M, Skiniotis, G. Deposit date: 2023-03-08 Release date: 2024-03-06 Last modified: 2024-11-20 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024

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