7QI3
| Structure of Fusarium verticillioides NAT1 (FDB2) N-malonyltransferase | Descriptor: | 1,2-ETHANEDIOL, Arylamine N-acetyltransferase, DI(HYDROXYETHYL)ETHER, ... | Authors: | Lowe, E.D, Kotomina, E, Karagianni, E, Boukouvala, S. | Deposit date: | 2021-12-14 | Release date: | 2022-11-23 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Fusarium verticillioides NAT1 (FDB2) N-malonyltransferase is structurally, functionally and phylogenetically distinct from its N-acetyltransferase (NAT) homologues. Febs J., 290, 2023
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8FY2
| E3:PROTAC:target ternary complex structure (VCB/WH244/BCL-2) | Descriptor: | Apoptosis regulator Bcl-2, Elongin-B, Elongin-C, ... | Authors: | Nayak, D, Lv, D, Yuan, Y, Zhang, P, Hu, W, Ruben, E, Lv, Z, Sung, P, Hromas, R, Zheng, G, Zhou, D, Olsen, S.K. | Deposit date: | 2023-01-25 | Release date: | 2024-04-10 | Method: | X-RAY DIFFRACTION (2.98 Å) | Cite: | Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL. Nat Commun, 15, 2024
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8FY0
| E3:PROTAC:target ternary complex structure (VCB/753b/BCL-xL) | Descriptor: | Bcl-2-like protein 1, CACODYLIC ACID, Elongin-B, ... | Authors: | Olsen, S.K, Nayak, D, Lv, D, Yuan, Y, Zhang, P, Hu, W, Lv, Z, Sung, P, Hromas, R, Zheng, G, Zhou, D. | Deposit date: | 2023-01-25 | Release date: | 2024-04-10 | Method: | X-RAY DIFFRACTION (2.94 Å) | Cite: | Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL. Nat Commun, 15, 2024
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8FY1
| E3:PROTAC:target ternary complex structure (VCB/753b/BCL-2) | Descriptor: | Apoptosis regulator Bcl-2, Elongin-B, Elongin-C, ... | Authors: | Nayak, D, Lv, D, Yuan, Y, Zhang, P, Hu, W, Lv, Z, Sung, P, Hromas, R, Zheng, G, Zhou, D, Olsen, S.K. | Deposit date: | 2023-01-25 | Release date: | 2024-04-10 | Method: | X-RAY DIFFRACTION (2.56 Å) | Cite: | Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL. Nat Commun, 15, 2024
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4YGX
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6LTR
| Crystal structure of Cas12i2 ternary complex with single Mg2+ bound in catalytic pocket | Descriptor: | 1,2-ETHANEDIOL, Cas12i2, DNA (35-MER), ... | Authors: | Huang, X, Sun, W, Cheng, Z, Chen, M, Li, X, Wang, J, Sheng, G, Gong, W, Wang, Y. | Deposit date: | 2020-01-23 | Release date: | 2020-10-28 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | Structural basis for two metal-ion catalysis of DNA cleavage by Cas12i2. Nat Commun, 11, 2020
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6LU0
| Crystal structure of Cas12i2 ternary complex with 12 nt spacer | Descriptor: | Cas12i2, DNA (5'-D(*GP*CP*CP*GP*CP*TP*TP*TP*CP*TP*T)-3'), DNA (5'-D(*GP*CP*TP*TP*GP*CP*TP*CP*TP*GP*TP*TP*GP*AP*AP*AP*GP*CP*GP*GP*C)-3'), ... | Authors: | Huang, X, Sun, W, Cheng, Z, Chen, M, Li, X, Wang, J, Sheng, G, Gong, W, Wang, Y. | Deposit date: | 2020-01-24 | Release date: | 2020-10-28 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.22 Å) | Cite: | Structural basis for two metal-ion catalysis of DNA cleavage by Cas12i2. Nat Commun, 11, 2020
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4B6U
| Solution structure of eIF4E3 in complex with m7GDP | Descriptor: | 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TYPE 3 | Authors: | Osborne, M.J, Volpon, L, Kornblatt, J.A, Culkjovic-Kraljcic, B, Baguet, A, Borden, K.L.B. | Deposit date: | 2012-08-15 | Release date: | 2013-03-06 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | Eif4E3 Acts as a Tumor Suppressor by Utilizing an Atypical Mode of Methyl-7-Guanosine CAP Recognition Proc.Natl.Acad.Sci.USA, 110, 2013
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6LTP
| Crystal structure of Cas12i2 binary complex | Descriptor: | Cas12i2, crRNA (56-mer RNA) | Authors: | Huang, X, Sun, W, Cheng, Z, Chen, M, Li, X, Wang, J, Sheng, G, Gong, W, Wang, Y. | Deposit date: | 2020-01-23 | Release date: | 2020-10-28 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Structural basis for two metal-ion catalysis of DNA cleavage by Cas12i2. Nat Commun, 11, 2020
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5UTF
| Crystal Structure of a Stabilized DS-SOSIP.6mut BG505 gp140 HIV-1 Env Trimer, Containing Mutations I201C-P433C (DS), L154M, Y177W, N300M, N302M, T320L, I420M in Complex with Human Antibodies PGT122 and 35O22 at 4.3 A | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 35022 Heavy chain, ... | Authors: | Pancera, M, Chuang, G.-Y, Xu, K, Kwong, P.D. | Deposit date: | 2017-02-14 | Release date: | 2017-03-29 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.503 Å) | Cite: | Structure-Based Design of a Soluble Prefusion-Closed HIV-1 Env Trimer with Reduced CD4 Affinity and Improved Immunogenicity. J. Virol., 91, 2017
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6LTU
| Crystal structure of Cas12i2 ternary complex with double Mg2+ bound in catalytic pocket | Descriptor: | 1,2-ETHANEDIOL, Cas12i2, DNA (35-MER), ... | Authors: | Huang, X, Sun, W, Cheng, Z, Chen, M, Li, X, Wang, J, Sheng, G, Gong, W, Wang, Y. | Deposit date: | 2020-01-23 | Release date: | 2020-10-28 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.57 Å) | Cite: | Structural basis for two metal-ion catalysis of DNA cleavage by Cas12i2. Nat Commun, 11, 2020
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3NJ0
| X-ray crystal structure of the PYL2-pyrabactin A complex | Descriptor: | 4-bromo-N-(pyridin-2-ylmethyl)naphthalene-1-sulfonamide, Abscisic acid receptor PYL2, DI(HYDROXYETHYL)ETHER, ... | Authors: | Peterson, F.C, Burgie, E.S, Bingman, C.A, Volkman, B.F, Phillips Jr, G.N, Cutler, S.R, Jensen, D.R, Center for Eukaryotic Structural Genomics (CESG) | Deposit date: | 2010-06-16 | Release date: | 2010-08-18 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Structural basis for selective activation of ABA receptors. Nat.Struct.Mol.Biol., 17, 2010
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5ANR
| Structure of a human 4E-T - DDX6 - CNOT1 complex | Descriptor: | CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TRANSPORTER, PROBABLE ATP-DEPENDENT RNA HELICASE DDX6 | Authors: | Basquin, J, Oezguer, S, Conti, E. | Deposit date: | 2015-09-08 | Release date: | 2015-10-21 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.102 Å) | Cite: | Structure of a Human 4E-T/Ddx6/Cnot1 Complex Reveals the Different Interplay of Ddx6-Binding Proteins with the Ccr4-not Complex. Cell Rep., 13, 2015
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3NJO
| X-ray crystal structure of the Pyr1-pyrabactin A complex | Descriptor: | 4-bromo-N-(pyridin-2-ylmethyl)naphthalene-1-sulfonamide, Abscisic acid receptor PYR1, CHLORIDE ION, ... | Authors: | Burgie, E.S, Bingman, C.A, Phillips Jr, G.N, Peterson, F.C, Volkman, B.F, Cutler, S.R, Jensen, D.R, Center for Eukaryotic Structural Genomics (CESG) | Deposit date: | 2010-06-17 | Release date: | 2010-08-18 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.473 Å) | Cite: | Structural basis for selective activation of ABA receptors. Nat.Struct.Mol.Biol., 17, 2010
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3NJ1
| X-ray crystal structure of the PYL2(V114I)-pyrabactin A complex | Descriptor: | 4-bromo-N-(pyridin-2-ylmethyl)naphthalene-1-sulfonamide, Abscisic acid receptor PYL2, GLYCEROL, ... | Authors: | Peterson, F.C, Burgie, E.S, Bingman, C.A, Volkman, B.F, Phillips Jr, G.N, Cutler, S.R, Jensen, D.R, Center for Eukaryotic Structural Genomics (CESG) | Deposit date: | 2010-06-16 | Release date: | 2010-08-18 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.948 Å) | Cite: | Structural basis for selective activation of ABA receptors. Nat.Struct.Mol.Biol., 17, 2010
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1LIN
| CALMODULIN COMPLEXED WITH TRIFLUOPERAZINE (1:4 COMPLEX) | Descriptor: | 10-[3-(4-METHYL-PIPERAZIN-1-YL)-PROPYL]-2-TRIFLUOROMETHYL-10H-PHENOTHIAZINE, CALCIUM ION, CALMODULIN | Authors: | Vandonselaar, M, Hickie, R.A, Quail, J.W, Delbaere, L.T.J. | Deposit date: | 1995-10-11 | Release date: | 1996-03-08 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Trifluoperazine-induced conformational change in Ca(2+)-calmodulin. Nat.Struct.Biol., 1, 1994
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2KTM
| Solution NMR structure of H2H3 domain of ovine prion protein (residues 167-234) | Descriptor: | Major prion protein | Authors: | Pastore, A, Adrover, M, Pauwels, K, de Chiara, C, Prigent, S, Rezeai, H. | Deposit date: | 2010-02-04 | Release date: | 2010-04-07 | Last modified: | 2021-11-10 | Method: | SOLUTION NMR | Cite: | Prion fibrillization is mediated by a native structural element that comprises helices H2 and H3. J.Biol.Chem., 285, 2010
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1GW2
| RECOMBINANT HORSERADISH PEROXIDASE C1A THR171SER IN COMPLEX WITH FERULIC ACID | Descriptor: | 3-(4-HYDROXY-3-METHOXYPHENYL)-2-PROPENOIC ACID, CALCIUM ION, PEROXIDASE C1A, ... | Authors: | Henriksen, A, Meno, K, Brissett, N, Gajhede, M. | Deposit date: | 2002-03-03 | Release date: | 2003-03-28 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Hrpc Heme Crevice Architecture To be Published
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6YVA
| PLpro-C111S with mISG15 | Descriptor: | Replicase polyprotein 1a, Ubiquitin-like protein ISG15, ZINC ION | Authors: | Shin, D, Dikic, I. | Deposit date: | 2020-04-28 | Release date: | 2020-05-13 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.18 Å) | Cite: | Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity. Nature, 587, 2020
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1MFQ
| Crystal Structure Analysis of a Ternary S-Domain Complex of Human Signal Recognition Particle | Descriptor: | 7S RNA of human SRP, CHLORIDE ION, MAGNESIUM ION, ... | Authors: | Kuglstatter, A, Oubridge, C, Nagai, K. | Deposit date: | 2002-08-13 | Release date: | 2002-09-20 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Induced structural changes of 7SL RNA during the assembly of human
signal recognition particle Nat.Struct.Biol., 9, 2002
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8BI9
| Structure of a cyclic beta-hairpin peptide derived from neuronal nitric oxide synthase (T112W/T116E variant) | Descriptor: | Nitric oxide synthase, brain, TERTIARY-BUTYL ALCOHOL | Authors: | Balboa, J.R, Ostergaard, S, Stromgaard, K, Knapp, S, Joerger, A.C, Structural Genomics Consortium (SGC) | Deposit date: | 2022-11-01 | Release date: | 2022-12-21 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.44 Å) | Cite: | Development of a Potent Cyclic Peptide Inhibitor of the nNOS/PSD-95 Interaction. J.Med.Chem., 66, 2023
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2ILU
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3EMM
| X-ray structure of protein from Arabidopsis thaliana AT1G79260 with Bound Heme | Descriptor: | 1,2-ETHANEDIOL, PROTOPORPHYRIN IX CONTAINING FE, Uncharacterized protein At1g79260 | Authors: | Bianchetti, C.M, Bingman, C.A, Wesenberg, G.E, Phillips Jr, G.N, Center for Eukaryotic Structural Genomics (CESG) | Deposit date: | 2008-09-24 | Release date: | 2008-10-14 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.358 Å) | Cite: | The structure and NO binding properties of the nitrophorin-like heme-binding protein from Arabidopsis thaliana gene locus At1g79260.1. Proteins, 78, 2010
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8P26
| Crystal structure of Arabidopsis thaliana PAXX | Descriptor: | U2 small nuclear ribonucleoprotein auxiliary factor-like protein | Authors: | Ochi, T. | Deposit date: | 2023-05-15 | Release date: | 2023-06-28 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Plant PAXX has an XLF-like function and stimulates DNA end joining by the Ku-DNA ligase IV/XRCC4 complex. Plant J., 116, 2023
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4XZ2
| Human platelet phosphofructokinase in an R-state in complex with ADP and F6P, crystal form I | Descriptor: | 1,6-di-O-phosphono-beta-D-fructofuranose, 6-O-phosphono-beta-D-fructofuranose, ADENOSINE-5'-DIPHOSPHATE, ... | Authors: | Kloos, M, Strater, N. | Deposit date: | 2015-02-03 | Release date: | 2015-06-03 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.67 Å) | Cite: | Crystal structure of human platelet phosphofructokinase-1 locked in an activated conformation. Biochem.J., 469, 2015
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