2ILU

Crystal structure of lactaldehyde dehydrogenase from E. coli: the binary complex with NADPH

Summary for 2ILU

Entry DOI	10.2210/pdb2ilu/pdb
Related	2HG2
Descriptor	Aldehyde dehydrogenase A, SULFATE ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total)
Functional Keywords	nadph-lactaldehyde dehydrogenase complex, oxidoreductase
Biological source	Escherichia coli
Total number of polymer chains	1
Total formula weight	53310.07
Authors	Di Costanzo, L.,Gomez, G.,Christianson, D.W. (deposition date: 2006-10-03, release date: 2007-05-08, Last modification date: 2023-11-15)
Primary citation	Di Costanzo, L.,Gomez, G.A.,Christianson, D.W. Crystal structure of lactaldehyde dehydrogenase from Escherichia coli and inferences regarding substrate and cofactor specificity. J.Mol.Biol., 366:481-493, 2007 Cited by PubMed Abstract: Aldehyde dehydrogenases catalyze the oxidation of aldehyde substrates to the corresponding carboxylic acids. Lactaldehyde dehydrogenase from Escherichia coli (aldA gene product, P25553) is an NAD(+)-dependent enzyme implicated in the metabolism of l-fucose and l-rhamnose. During the heterologous expression and purification of taxadiene synthase from the Pacific yew, lactaldehyde dehydrogenase from E. coli was identified as a minor (PubMed: 17173928 DOI: 10.1016/j.jmb.2006.11.023 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation