5UTF

Crystal Structure of a Stabilized DS-SOSIP.6mut BG505 gp140 HIV-1 Env Trimer, Containing Mutations I201C-P433C (DS), L154M, Y177W, N300M, N302M, T320L, I420M in Complex with Human Antibodies PGT122 and 35O22 at 4.3 A

Summary for 5UTF

• Entry DOI: 10.2210/pdb5utf/pdb
• Descriptor: Envelope glycoprotein gp120, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (13 entities in total)
• Functional Keywords: hiv-1 env, stabilized env, near-native mimic of the viral spike, immune system
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 6
• Total formula weight: 180523.93

Authors

Pancera, M.,Chuang, G.-Y.,Xu, K.,Kwong, P.D. (deposition date: 2017-02-14, release date: 2017-03-29, Last modification date: 2023-10-04)

• Primary citation: Chuang, G.Y.,Geng, H.,Pancera, M.,Xu, K.,Cheng, C.,Acharya, P.,Chambers, M.,Druz, A.,Tsybovsky, Y.,Wanninger, T.G.,Yang, Y.,Doria-Rose, N.A.,Georgiev, I.S.,Gorman, J.,Joyce, M.G.,O'Dell, S.,Zhou, T.,McDermott, A.B.,Mascola, J.R.,Kwong, P.D.; Structure-Based Design of a Soluble Prefusion-Closed HIV-1 Env Trimer with Reduced CD4 Affinity and Improved Immunogenicity.; J. Virol., 91:-, 2017; PubMed: 28275193; DOI: 10.1128/JVI.02268-16

Experimental method

X-RAY DIFFRACTION (3.503 Å)