8U2Z
 
 | | TRPV1 in nanodisc bound with diC8-PIP2 in the dilated state | | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHOLESTEROL, SODIUM ION, ... | | Authors: | Arnold, W.R, Julius, D, Cheng, Y. | | Deposit date: | 2023-09-06 | | Release date: | 2024-05-08 | | Last modified: | 2025-05-14 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structural basis of TRPV1 modulation by endogenous bioactive lipids.
Nat.Struct.Mol.Biol., 31, 2024
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8U3J
 | | TRPV1 in nanodisc bound with empty vanilloid binding pocket at 4C | | Descriptor: | 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, SODIUM ION, Transient receptor potential cation channel subfamily V member 1 | | Authors: | Arnold, W.R, Julius, D, Cheng, Y. | | Deposit date: | 2023-09-07 | | Release date: | 2024-05-08 | | Last modified: | 2025-05-21 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structural basis of TRPV1 modulation by endogenous bioactive lipids.
Nat.Struct.Mol.Biol., 31, 2024
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8U4D
 | | TRPV1 in nanodisc bound with PI-Br4, consensus structure | | Descriptor: | (2S)-2-[(9,10-dibromooctadecanoyl)oxy]-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propyl (9R,10S)-9,10-dibromooctadecanoate, SODIUM ION, Transient receptor potential cation channel subfamily V member 1 | | Authors: | Arnold, W.R, Julius, D, Cheng, Y. | | Deposit date: | 2023-09-10 | | Release date: | 2024-05-08 | | Last modified: | 2025-05-28 | | Method: | ELECTRON MICROSCOPY (2.2 Å) | | Cite: | Structural basis of TRPV1 modulation by endogenous bioactive lipids.
Nat.Struct.Mol.Biol., 31, 2024
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8U43
 | | TRPV1 in nanodisc bound with PIP2-Br4 | | Descriptor: | (2S)-2-[(9,10-dibromooctadecanoyl)oxy]-3-{[(S)-hydroxy{[(1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propyl (9R,10S)-9,10-dibromooctadecanoate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, SODIUM ION, ... | | Authors: | Arnold, W.R, Julius, D, Cheng, Y. | | Deposit date: | 2023-09-08 | | Release date: | 2024-05-08 | | Last modified: | 2024-10-02 | | Method: | ELECTRON MICROSCOPY (2.4 Å) | | Cite: | Structural basis of TRPV1 modulation by endogenous bioactive lipids.
Nat.Struct.Mol.Biol., 31, 2024
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2JOF
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5AN8
 | | Cryo-electron microscopy structure of rabbit TRPV2 ion channel | | Descriptor: | TRPV2 | | Authors: | Zubcevic, L, Herzik, M.A.J, Chung, B.C, Lander, G.C, Lee, S.Y. | | Deposit date: | 2015-09-04 | | Release date: | 2015-12-23 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Cryo-Electron Microscopy of the Trpv2 Ion Channel
Nat.Struct.Mol.Biol., 23, 2016
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1TRP
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6BWF
 | | 4.1 angstrom Mg2+-unbound structure of mouse TRPM7 | | Descriptor: | TRPM7 | | Authors: | Zhang, J, Li, Z, Duan, J, Abiria, S.A, Clapham, D.E. | | Deposit date: | 2017-12-14 | | Release date: | 2018-08-15 | | Last modified: | 2025-06-04 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Structure of the mammalian TRPM7, a magnesium channel required during embryonic development.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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2M7C
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1JHG
 | | TRP REPRESSOR MUTANT V58I | | Descriptor: | PHOSPHATE ION, TRP OPERON REPRESSOR, TRYPTOPHAN | | Authors: | Lawson, C.L. | | Deposit date: | 1996-07-19 | | Release date: | 1997-03-12 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | An atomic view of the L-tryptophan binding site of trp repressor.
Nat.Struct.Biol., 3, 1996
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6L93
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5TM0
 | | Solution NMR structures of two alternative conformations of E. coli tryptophan repressor in dynamic equilibrium | | Descriptor: | Trp operon repressor | | Authors: | Harish, B, Swapna, G.V.T, Kornhaber, G.J, Montelione, G.T, Carey, J, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2016-10-12 | | Release date: | 2017-10-25 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Multiple helical conformations of the helix-turn-helix region revealed by NOE-restrained MD simulations of tryptophan aporepressor, TrpR.
Proteins, 85, 2017
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6O20
 | | Cryo-EM structure of TRPV5 with calmodulin bound | | Descriptor: | CALCIUM ION, Calmodulin, Transient receptor potential cation channel subfamily V member 5 | | Authors: | Dang, S, van Goor, M.K, Asarnow, D, Wang, Y, Julius, D, Cheng, Y, van der Wijst, J. | | Deposit date: | 2019-02-22 | | Release date: | 2019-04-24 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural insight into TRPV5 channel function and modulation.
Proc.Natl.Acad.Sci.USA, 116, 2019
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6O1N
 | | Cryo-EM structure of TRPV5 (1-660) in nanodisc | | Descriptor: | Transient receptor potential cation channel subfamily V member 5 | | Authors: | Dang, S, van Goor, M.K, Asarnow, D, Wang, Y, Julius, D, Cheng, Y, van der Wijst, J. | | Deposit date: | 2019-02-21 | | Release date: | 2019-04-24 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structural insight into TRPV5 channel function and modulation.
Proc.Natl.Acad.Sci.USA, 116, 2019
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6O1U
 | | Cryo-EM structure of TRPV5 W583A in nanodisc | | Descriptor: | Transient receptor potential cation channel subfamily V member 5 | | Authors: | Dang, S, van Goor, M.K, Asarnow, D, Wang, Y, Julius, D, Cheng, Y, van der Wijst, J. | | Deposit date: | 2019-02-21 | | Release date: | 2019-04-24 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Structural insight into TRPV5 channel function and modulation.
Proc.Natl.Acad.Sci.USA, 116, 2019
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6O1P
 | | Cryo-EM structure of full length TRPV5 in nanodisc | | Descriptor: | Transient receptor potential cation channel subfamily V member 5 | | Authors: | Dang, S, van Goor, M.K, Asarnow, D, Wang, Y, Julius, D, Cheng, Y, van der Wijst, J. | | Deposit date: | 2019-02-21 | | Release date: | 2019-04-24 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structural insight into TRPV5 channel function and modulation.
Proc.Natl.Acad.Sci.USA, 116, 2019
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6BO5
 | | TRPV2 ion channel in partially closed state | | Descriptor: | Transient receptor potential cation channel subfamily V member 2 | | Authors: | Dosey, T.L, Wang, Z. | | Deposit date: | 2017-11-18 | | Release date: | 2018-12-05 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structures of TRPV2 in distinct conformations provide insight into role of the pore turret.
Nat.Struct.Mol.Biol., 26, 2019
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1QAW
 | | Regulatory Features of the TRP Operon and the Crystal Structure of the TRP RNA-Binding Attenuation Protein from Bacillus Stearothermophilus. | | Descriptor: | TRP RNA-BINDING ATTENUATION PROTEIN, TRYPTOPHAN | | Authors: | Chen, X.-P, Antson, A.A, Yang, M, Baumann, C, Dodson, E.J, Dodson, G.G, Gollnick, P. | | Deposit date: | 1999-03-31 | | Release date: | 1999-04-16 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Regulatory features of the trp operon and the crystal structure of the trp RNA-binding attenuation protein from Bacillus stearothermophilus.
J.Mol.Biol., 289, 1999
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7S8C
 | | Cryo-EM structure of human TRPV6 in complex with inhibitor econazole | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1-[(2R)-2-[(4-chlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole, CALCIUM ION, ... | | Authors: | Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. | | Deposit date: | 2021-09-17 | | Release date: | 2021-11-17 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (2.85 Å) | | Cite: | Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole.
Nat Commun, 12, 2021
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7S88
 | | Open apo-state cryo-EM structure of human TRPV6 in glyco-diosgenin detergent | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CALCIUM ION, ... | | Authors: | Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. | | Deposit date: | 2021-09-17 | | Release date: | 2021-11-17 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (2.69 Å) | | Cite: | Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole.
Nat Commun, 12, 2021
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7S89
 | | Open apo-state cryo-EM structure of human TRPV6 in cNW11 nanodiscs | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CALCIUM ION, ... | | Authors: | Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. | | Deposit date: | 2021-09-17 | | Release date: | 2021-11-17 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (2.54 Å) | | Cite: | Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole.
Nat Commun, 12, 2021
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7S8B
 | | Cryo-EM structure of human TRPV6 in complex with channel blocker ruthenium red | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CALCIUM ION, ... | | Authors: | Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. | | Deposit date: | 2021-09-17 | | Release date: | 2021-11-17 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (2.43 Å) | | Cite: | Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole.
Nat Commun, 12, 2021
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7RAS
 | | Structure of TRPV3 in complex with osthole | | Descriptor: | 7-methoxy-8-(3-methylbut-2-enyl)chromen-2-one, Transient receptor potential cation channel subfamily V member 3 | | Authors: | Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. | | Deposit date: | 2021-07-02 | | Release date: | 2021-09-08 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.64 Å) | | Cite: | Structural mechanism of TRPV3 channel inhibition by the plant-derived coumarin osthole.
Embo Rep., 22, 2021
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7RAU
 | | Structure of TRPV3 in complex with osthole | | Descriptor: | 7-methoxy-8-(3-methylbut-2-enyl)chromen-2-one, Transient receptor potential cation channel subfamily V member 3 | | Authors: | Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. | | Deposit date: | 2021-07-02 | | Release date: | 2021-09-08 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.99 Å) | | Cite: | Structural mechanism of TRPV3 channel inhibition by the plant-derived coumarin osthole.
Embo Rep., 22, 2021
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9CUK
 | | Structure of human full-length derived TRPV6 channel in Calmodulin-bound state | | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CALCIUM ION, CHOLESTEROL, ... | | Authors: | Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. | | Deposit date: | 2024-07-26 | | Release date: | 2024-11-13 | | Last modified: | 2025-01-15 | | Method: | ELECTRON MICROSCOPY (3.26 Å) | | Cite: | Structure-function analyses of human TRPV6 ancestral and derived haplotypes.
Structure, 33, 2025
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