8U2Z

TRPV1 in nanodisc bound with diC8-PIP2 in the dilated state

Summary for 8U2Z

• Entry DOI: 10.2210/pdb8u2z/pdb
• EMDB information: 41847
• Descriptor: Transient receptor potential cation channel subfamily V member 1, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... (6 entities in total)
• Functional Keywords: trpv1 in nanodisc bound with dic8-pip2 in the dilated state, membrane protein
• Biological source: Rattus norvegicus (Norway rat)
• Total number of polymer chains: 4
• Total formula weight: 299257.26

Authors

Arnold, W.R.,Julius, D.,Cheng, Y. (deposition date: 2023-09-06, release date: 2024-05-08, Last modification date: 2024-05-15)

• Primary citation: Arnold, W.R.,Mancino, A.,Moss 3rd, F.R.,Frost, A.,Julius, D.,Cheng, Y.; Structural basis of TRPV1 modulation by endogenous bioactive lipids.; Nat.Struct.Mol.Biol., 2024; PubMed: 38698206; DOI: 10.1038/s41594-024-01299-2

Experimental method

ELECTRON MICROSCOPY (3.6 Å)